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Hexarelin
Pick your pack · how long it lasts
At 1.40 mg/wk — select pack size
1 × 10-vial pack required for packing — samples add on to any pack
Lab-direct quality — full packs or single-vial samples
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a batch-linked Certificate of Analysis. Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a full sealed 10-vial research pack for a complete study supply, or add a single-vial sample alongside your pack to trial a new compound first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
In plain terms, hexarelin is one of the strongest growth-hormone releasers studied, with an unusual second action on the heart. Here is what that looks like across the research.
Strong GH release
Research explores how it produces one of the largest growth-hormone pulses of any compound in this family per dose.
Heart & cardiac research
Animal studies look at a separate, growth-hormone-independent action on heart cells, an angle unique to hexarelin in this class.
Muscle & lean mass
Studied for how its powerful growth-hormone and IGF-1 signal supports lean mass and recovery.
Combined research
Investigated alongside GHRH compounds, where even a small partner dose produces a much larger combined growth-hormone release.
Tolerance studies
A classic tool for studying how the response fades with constant use and recovers after a break, which is why research favours lower amounts and cycling.
Overview
Hexarelin is a potent six-amino-acid growth hormone secretagogue that uniquely activates both the ghrelin receptor (for GH release) and CD36 scavenger receptors on cardiomyocytes (for cardioprotective signalling).
Hexarelin (also known as examorelin) is a synthetic hexapeptide built on the GHRP-6 scaffold with two non-natural amino-acid substitutions (D-2-methyltryptophan and D-phenylalanine) that dramatically improve metabolic stability. It binds the ghrelin receptor GHS-R1a very tightly and releases more GH per dose than even native GHRH.
What makes hexarelin genuinely unusual is its second receptor. Alongside its GH-releasing activity, it activates CD36 scavenger receptors on heart muscle cells, producing cardioprotective effects that are independent of GH release entirely. Phase II trials explored hexarelin for both growth hormone deficiency and congestive heart failure.
Hexarelin is widely used in research as a potent GH release benchmark and as a tool compound for studying CD36 signalling in cardiac tissue. Supplied here as sterile lyophilised powder for preclinical research.
Mechanism of Action
Hexarelin hits two receptors: GHS-R1a on pituitary cells to release growth hormone, and CD36 on heart cells to improve cardiac function - a dual-target pharmacology no other GHRP matches.
Ghigo et al. (European Journal of Clinical Pharmacology, 1996) showed that hexarelin + very low-dose GHRH (0.125 mcg/kg) produces massive synergistic GH release with minimal cortisol or prolactin change. Bisi et al. (JCEM, 1999) characterised the cardioprotective CD36 arm, showing calcium channel modulation in cardiomyocytes independent of GH. GH Tmax ≈ 30 min; GH returns to baseline within 240 min; functional SC t½ ≈ 1-2 h. Chronic use produces partial reversible tolerance (50-75% efficacy reduction over weeks).
Common Questions People Are Asking
How is hexarelin different from GHRP-6?
Hexarelin is a more potent version of the GHRP-6 scaffold with two non-natural amino-acid substitutions (D-2-methyltryptophan and D-phenylalanine) that improve stability and GH-releasing potency. It also has clearer CD36-mediated cardiac effects than the simpler GHRP-6.
What is the CD36 mechanism doing in cardiac tissue?
CD36 is a scavenger receptor that handles fatty acid uptake and calcium channel modulation in cardiomyocytes. Hexarelin activation of cardiac CD36 improves calcium handling and has been proposed as a mechanism for its cardioprotective effects in post-ischemic injury models.
Does hexarelin cause cortisol elevation?
Yes, hexarelin produces some cortisol and prolactin elevation at higher doses, more than ipamorelin but generally less than GHRP-6. Low-dose protocols minimise those secondary effects while preserving GH release.
How should hexarelin be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The non-natural amino acid substitutions give it better shelf stability than simpler GHRPs.
Hexarelin vs ipamorelin - how do they compare?
Both are ghrelin-receptor (GHSR) agonists that release growth hormone, but hexarelin is the more potent GH releaser and adds CD36-mediated cardiac activity, while ipamorelin is the cleaner, more selective option with minimal cortisol, prolactin or appetite effect. Hexarelin also desensitises faster with continuous exposure. See our Hexarelin vs Ipamorelin research comparison for the full mechanism breakdown.
Hexarelin vs GHRP-2 - what is the difference?
Both are hexapeptide ghrelin-receptor agonists, but hexarelin is the more potent GH releaser per dose and uniquely adds CD36-mediated cardiac activity, while GHRP-2 produces a more modest GH pulse with a milder cortisol and prolactin profile. Hexarelin also desensitises (loses effect) faster with sustained exposure, which is why research protocols built around it favour lower amounts and cycling. Both are supplied strictly for laboratory research, not human use.
What hexarelin dosage is used in research?
Research protocols describe low-microgram subcutaneous amounts, often split through the day, with lower amounts used to limit cortisol/prolactin rise and receptor desensitisation. New-U publishes this as descriptive research context only - it is not a dosing instruction, and hexarelin is supplied strictly for laboratory research, not human use.
What is hexarelin studied for?
Beyond growth-hormone release, hexarelin is studied for CD36-mediated cardioprotective effects in post-ischaemic injury models and for calcium-handling in cardiomyocytes - an angle the simpler GHRPs lack. These are preclinical research findings; New-U makes no therapeutic claims and sells hexarelin for research use only.
Does hexarelin lose effect over time (desensitisation)?
Yes - continuous high-amount exposure downregulates the ghrelin receptor and blunts the GH response faster than with ipamorelin, which is why research protocols favour lower amounts and cycling. Reported for research context only, not a human-use protocol.
Where can I buy Hexarelin?
Right here — Hexarelin is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging. Strictly for laboratory research use only — not for human use.
How much does Hexarelin cost?
Hexarelin pricing is shown live on this page, per pack size — 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $300.
Is Hexarelin third-party tested?
Yes. Every Hexarelin batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy Hexarelin?
Add the Hexarelin pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). Hexarelin is supplied strictly for laboratory research use only, not for human or veterinary use.
What payment methods can I use to buy Hexarelin?
At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.
Is it legal to buy Hexarelin?
In the United States, Hexarelin is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction — buyers are responsible for compliance in their own region.
Pharmacokinetics
Evidence Tier
Overall: Tier 2: Animal / preclinical
Hexarelin (examorelin) has genuine human endocrine-challenge pharmacology and reached Phase II trials in two indications, but none led to approval. It is not approved by any regulator for human therapeutic use; the material supplied here is unapproved research material.
Tier 1 · Human clinical
Tier 2 · Animal
Source References & Further Reading
Last reviewed: 16 June 2026 · New-U Research Compounds
Key Characteristics
Specifications
About Hexarelin: Potent GH Secretagogue & Cardioprotective Research Guide
Hexarelin (examorelin) occupies a unique spot in the growth hormone releasing peptide family. It is the most potent GH releaser that the classical GHRP scaffold has produced, but it is also the only GHRP with well-characterised activity at a second receptor (CD36) that has nothing to do with GH. That dual pharmacology is why hexarelin reached Phase II clinical trials in two completely different conditions - growth hormone deficiency and congestive heart failure.
In comparative studies, hexarelin with even sub-threshold GHRH produces what the original investigators described as "massive" synergistic GH release - far larger than the sum of the two components alone. That synergy is the foundation of the modern stack philosophy where a GHRP and a GHRH analog are combined to exploit two complementary receptors.
New-U Research Compounds supplies hexarelin as a research-grade lyophilised powder at >99% HPLC purity, verified by independent third-party labs. All material is for in-vitro and preclinical research only. Hexarelin is not approved for human therapeutic use, and nothing on this page constitutes medical advice.
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