Shop by goal

Popular compounds

Research resources

Recently viewed

How-to guides

Premium research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical with a Certificate of Analysis on every lot. Shipped lab-direct, discreet and cold-chain, worldwide. For laboratory research use only.

Shop

  • All Peptides
  • Fat-Loss Peptides
  • Skin & Anti-Aging
  • Stacks & Protocols
  • Compare Vials
  • Peptide 101

    • Learn

  • Research Blog
  • How-To Guides
  • Certificates of Analysis
  • Community Forum

    • Company

  • About Us
  • Contact
  • FAQ
  • Affiliate Program
  • VIP Club

    • Support

  • Shipping & Delivery
  • Pay with Crypto
  • Live Crypto Prices
  • Refund Policy
  • Privacy
  • Terms

    • Ways to Pay

  • Google Pay
  • Apple Pay
  • Venmo
  • PayPal
  • Crypto
  • Cash App
  • Credit Card
  • SEPA

    • Shop by Compound

  • BPC-157
  • TB-500
  • GHK-Cu
  • Tesamorelin
  • Retatrutide
  • Semaglutide
  • Tirzepatide
  • CJC-1295 (without DAC)
  • View all compounds →

    • Shop by Goal

  • Fat Loss
  • Growth Hormone
  • Muscle Growth
  • Tissue Repair
  • Recovery
  • Anti-Aging
  • Cognitive
  • Accessories

    • Ships worldwide

  • United Kingdom
  • Australia
  • Canada
  • Canada (FR)
  • Ireland
  • Malta
  • Germany
  • France
  • Spain
  • Italy
  • Netherlands
  • Portugal
  • Greece
  • Austria
  • Poland
  • Sweden
  • Finland
  • Denmark
  • Norway
  • Croatia
  • Slovakia
  • Slovenia
  • Estonia
  • Latvia
  • Lithuania
  • Czechia
  • Hungary
  • Romania
  • Bulgaria
  • Belgium
  • Belgium (FR)
  • Luxembourg
  • USA

    • Research use only (RUO). All products are sold strictly for laboratory and research purposes — not for human or veterinary consumption. Purchasers must be 21 or older.

    All rights reserved. Copyright of New-U held with Hilxera Distribution Services LLC 2026.

    Website & business operated by Hilxera Distribution Services LLC. Registered in Wyoming, ID: 2026-001928701.

    © 2026 New-U Research Compounds · new-u.io · @new.u.io

    TB-500

    Pick your pack · how long it lasts

    At 2.50 mg/wk — select pack size

    1 × 10-vial pack required for packing — samples add on to any pack

    Lab-direct quality — full packs or single-vial samples

    Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a batch-linked Certificate of Analysis. Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.

    Order a full sealed 10-vial research pack for a complete study supply, or add a single-vial sample alongside your pack to trial a new compound first. Same lab, same batch, same verified purity — scaled to whatever your research needs.

    What It's Researched For

    In plain terms, TB-500 is studied mainly as a whole-body recovery and tissue-repair compound. Here is what that looks like across the research.

    Tendon & ligament recovery

    Animal studies look at faster healing and the return of mechanical strength after tendon and ligament injuries.

    Muscle repair

    Preclinical research explores quicker recovery of skeletal muscle after crush and exercise-type damage.

    Blood-vessel growth

    Studied for forming new blood vessels, the supply line that injured tissue needs to heal.

    Heart tissue recovery

    Animal models investigate less scarring and better function after heart-muscle injury.

    Eye-surface healing

    Research examines faster healing of the cornea after surface injury in animal models.

    Flexibility & stiffness

    Early research explores whether it eases stiffness by reducing scar-like tissue and adhesions.

    Overview

    TB-500 is a synthetic acetylated heptapeptide fragment derived from the actin-binding region of Thymosin Beta-4, studied in preclinical models of tissue repair, cell migration, angiogenesis, and inflammatory signalling.

    TB-500 (Ac-LKKTETQ) reproduces the actin-binding domain of Thymosin Beta-4, one of the most abundant repair proteins in the body. The full-length parent protein is 43 amino acids long and is present in nearly every cell, but the seven-residue fragment is far cheaper to synthesise and recovers most of the parent's biological activity in animal studies.

    Investigators use TB-500 as a laboratory tool compound for studying how tissue repair, new blood-vessel growth, and cell migration are coordinated after injury, without working with the full-length 43-residue parent protein. It is widely cited in tendon, ligament, muscle, heart, and cornea repair literature.

    Published findings remain preclinical or investigational and should not be interpreted as approval for therapeutic use. TB-500 is not approved for human use by any regulator and is on the WADA prohibited list for competing athletes.

    Supplied strictly for qualified laboratory research. Not for human use, veterinary use, diagnostic use, food use, cosmetic use, or athletic performance use.

    Mechanism of Action

    TB-500 binds loose (G-) actin inside cells and tunes down the inflammatory master switch NF-κB, helping cells migrate into damaged tissue and dampening the local inflammatory response.

    Pathway Effect Why it matters G-actin sequestration Binds free G-actin monomers 1:1 with ~0.5 μM affinity Regulates the pool of polymerisable actin needed for cell migration and shape change NF-κB / RelA-p65 Blocks nuclear translocation of the p65 subunit Lowers TNF-α-driven expression of IL-8 and other inflammatory cytokines VEGF / angiogenesis Drives endothelial cell migration and tube formation Builds the new capillary network repair tissue needs for oxygen and nutrients Cell migration Activates keratinocyte, fibroblast, and endothelial migration Accelerates closure of skin, tendon, and corneal wounds in animal models Laminin-5 upregulation Boosts basement-membrane laminin deposition Supports epithelial re-attachment during wound healing Deeper dive for scientific readers

    Malinda et al. (Journal of Investigative Dermatology, 1999) showed that the synthetic actin-binding heptapeptide recapitulates most of full-length Tβ4 wound-healing activity, including effects in healthy, diabetic, and aged mice. Goldstein and colleagues (Annals of the New York Academy of Sciences, 2012) reviewed the pharmacology across injury models. Rodent pharmacokinetics put subcutaneous Cmax at 200-400 ng/mL within 0.5-1 h and elimination t½ at 1.5-3 h, a short half-life characteristic of small unstructured peptides.

    Common Questions People Are Asking

    What is TB-500?

    TB-500 is a synthetic seven-amino-acid peptide (Ac-LKKTETQ) corresponding to the actin-binding region of Thymosin Beta-4, a protein found naturally in most human cells. It is made by solid-phase peptide synthesis and supplied as a lyophilised research-grade powder for laboratory use only.

    What does TB-500 do?

    In preclinical research TB-500 is studied as a tissue-repair and cell-migration peptide. Published animal studies report regulation of G-actin (cytoskeletal remodelling), promotion of angiogenesis (new blood-vessel growth), endothelial and keratinocyte migration, and modulation of NF-κB-driven inflammation. These are findings in cell and animal models, not demonstrated human effects.

    What is TB-500 used for?

    In the research literature TB-500 is used as a tool compound to study tendon, ligament, muscle, cardiac and wound-tissue repair, plus cell migration and angiogenesis. New-U supplies it strictly for in-vitro and animal-model research; it is not for human use and no therapeutic use is implied.

    Is TB-500 safe?

    In published animal studies TB-500 has generally been well tolerated, but there are no controlled human safety trials, so human safety is not established. It is also WADA-prohibited for competing athletes. It is a research compound, not a medicine; New-U makes no human-use or safety claims and supplies it for laboratory research only.

    How much TB-500 is used in research?

    Experimental parameters in the published literature vary widely by model, species, route, formulation and study endpoint, so there is no single standard figure. Any quantities reported in studies are experimental parameters from controlled research settings only — New-U does not provide human-use dosing, administration, cycle, or protocol guidance, and TB-500 is supplied strictly for laboratory research.

    What is the difference between TB-500 and Thymosin Beta-4?

    Thymosin Beta-4 is the full 43-amino-acid protein found naturally in most human cells. TB-500 is a synthetic seven-amino-acid fragment (Ac-LKKTETQ) that preserves the actin-binding domain responsible for most of the parent protein's wound-healing activity. The shorter peptide is much cheaper to synthesise and is widely used as a research surrogate.

    How does TB-500 compare with BPC-157?

    Both are research peptides in the healing category but they act through different mechanisms. BPC-157 primarily drives VEGFR2/eNOS and FAK signalling, while TB-500 works through actin regulation and NF-κB modulation. Many preclinical protocols combine them to exploit the distinct pathways.

    Is TB-500 approved for human use?

    No. TB-500 is an investigational research peptide and is not approved for human therapeutic use by any major regulator. It is also on the World Anti-Doping Agency (WADA) prohibited list for competing athletes. Material is supplied strictly for laboratory research.

    How should TB-500 research material be stored?

    Store the lyophilised powder frozen and protected from light. Once placed into solution under laboratory conditions, keep it cold (1–6 °C) and protected from light, and follow the batch-specific handling documentation. Peptide material degrades slowly under cold, dark storage.

    What vial sizes does New-U offer for TB-500, and how is it reconstituted?

    New-U supplies TB-500 in 10-vial research packs at 5 mg and 10 mg per vial, with the larger vials lowering the per-mg cost. For laboratory preparation, lyophilised TB-500 is dissolved in bacteriostatic water: concentration in mg/mL equals the vial mass in mg divided by the millilitres of diluent added (e.g. a 5 mg vial in 2.5 mL gives 2 mg/mL). All material is research-use-only; no human-use dosing instructions are provided.

    What is the molecular weight and half-life of TB-500?

    The TB-500 fragment (Ac-LKKTETQ, formula C₃₇H₆₆N₁₀O₁₄) has a molecular weight of 889.02 Da, far smaller than the 4921 Da full-length 43-amino-acid Thymosin Beta-4 it derives from. Rodent pharmacokinetics report a subcutaneous elimination half-life of roughly 1.5-3 hours, with peak plasma concentration (Cmax 200-400 ng/mL) reached 0.5-1 hour after dosing.

    Why do researchers run the BPC-157 + TB-500 stack?

    TB-500 and BPC-157 are studied together because they support tissue repair through different mechanisms: TB-500 through G-actin regulation, angiogenesis, and NF-κB modulation, and BPC-157 through the VEGFR2/eNOS pathway and growth-hormone-receptor upregulation. New-U Research Compounds supplies both as separate research-grade vials for laboratories investigating the combination. This is a research observation, not a human-use protocol.

    Is TB-500 banned in sport?

    Yes. TB-500 (and Thymosin Beta-4-related peptides) are on the World Anti-Doping Agency (WADA) prohibited list at all times. New-U supplies TB-500 strictly for in-vitro and preclinical laboratory research, not for human use, veterinary use, or athletic performance enhancement.

    What happens if you stop taking peptides?

    It depends on the peptide. TB-500 (a Thymosin Beta-4 fragment) has a relatively short residence time, so once administration stops in a study the compound clears and no longer engages actin-binding and cell-migration pathways — observed tissue-repair processes lose ongoing stimulus rather than reversing abruptly. Unlike hormone-axis peptides, the research literature does not describe a suppression-rebound on cessation. These are preclinical research observations; TB-500 is supplied for laboratory research only and is not for human use.

    Where can I buy TB-500?

    Right here — TB-500 is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging. Strictly for laboratory research use only — not for human use.

    How much does TB-500 cost?

    TB-500 pricing is shown live on this page, per pack size — 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $300.

    Is TB-500 third-party tested?

    Yes. Every TB-500 batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.

    How do I buy TB-500?

    Add the TB-500 pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). TB-500 is supplied strictly for laboratory research use only, not for human or veterinary use.

    What payment methods can I use to buy TB-500?

    At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.

    How fast is shipping, and do you ship worldwide?

    Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.

    Is it legal to buy TB-500?

    In the United States, TB-500 is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction — buyers are responsible for compliance in their own region.

    Pharmacokinetics

    Half-life 1.5–3 h elimination half-life (subcutaneous, rodent models) Absorption route Subcutaneous administration in rodent PK; Cmax 200–400 ng/mL at Tmax 0.5–1 h (6 mg/kg) Metabolism / clearance Endogenous proteolytic cleavage of the heptapeptide; no characterised cytochrome-P450 involvement Stability Lyophilised material stable when stored frozen and protected from light; reconstituted material handled cold per batch-specific documentation Notes Full-length Thymosin Beta-4 MW 4921 Da (43 aa); the TB-500 fragment MW 889 Da (7 aa). As an intrinsically unstructured peptide it adopts minimal secondary structure in solution.

    Research-Observed Effects

  • Accelerated wound closure in healthy, diabetic, and aged murine models (synthetic actin-binding fragment)
  • Increased endothelial-cell migration and tube formation in angiogenesis assays
  • Faster mechanical-strength recovery in rodent tendon and ligament transection models
  • Reduced fibrosis and improved function in post-infarct cardiac models (full-length Tβ4 read-across)
  • Enhanced corneal epithelial migration and wound closure in ocular abrasion models
  • Suppressed NF-κB-driven inflammatory cytokine expression in cell-based systems

    • Published Research Context

    TB-500 and Thymosin Beta-4-related peptides appear across preclinical tissue-repair literature. Experimental parameters vary widely by model, species, route, formulation, injury type, and study endpoint.

    New-U does not provide human dosing instructions, administration guidance, cycle planning, or performance-use recommendations. Any quantities reported in published studies are experimental parameters from controlled research settings only.

    Stacking Compatibility

    Compatible compounds

  • BPC-157: The "Wolverine stack" — complementary repair mechanisms: TB-500 regulates G-actin and NF-κB while BPC-157 drives VEGFR2/eNOS angiogenesis
  • GHK-Cu: Copper-peptide collagen and tissue-remodelling pathways studied alongside actin-driven cell migration in repair models

    • Side Effects (Observed in Literature)

    Common

  • No consistently reported adverse effects in preclinical studies; generally well tolerated in animal models

    • Rare

  • Injection-site reactions; transient fatigue or head-rush described anecdotally (uncontrolled self-report, not research data)

    • Dose-dependent

  • No controlled human dose–response data exists; human safety is not established
  • WADA-prohibited at all times for competing athletes

    • Evidence Tier

    Overall: Tier 2: Animal / preclinical

    Evidence for the TB-500 fragment is predominantly preclinical (rodent and in-vitro). Full-length Thymosin Beta-4 has progressed to early human studies in selected dermal and corneal repair indications. No regulator has approved TB-500 for human therapeutic use; it is WADA-prohibited for competing athletes.

    Tier 1 · Human clinical

  • Early-phase clinical work on full-length Thymosin Beta-4 in dermal and corneal repair indications (parent-protein read-across, not the TB-500 fragment itself)

    • Tier 2 · Animal

  • Malinda et al., Journal of Investigative Dermatology, 1999: synthetic actin-binding heptapeptide accelerates wound healing in healthy, diabetic, and aged mice
  • Goldstein et al., Annals of the New York Academy of Sciences, 2012: pharmacology review across injury models
  • Rodent tendon, ligament, skeletal-muscle, and corneal repair models

    • Tier 3 · Anecdotal

  • Unverified self-experiment reports in athletic-recovery communities (not controlled research)

    • Source References & Further Reading

    Last reviewed: 16 June 2026 · New-U Research Compounds

  • Malinda KM, Sidhu GS, Mani H, et al. Thymosin β4 accelerates wound healing. Journal of Investigative Dermatology, 1999. · 1999
  • Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin β4: pharmacology across injury models. Annals of the New York Academy of Sciences, 2012. · 2012
  • PubMed: peer-reviewed literature on TB-500
  • ClinicalTrials.gov: registered studies on TB-500
  • TB-500: Wikipedia
  • WebMD: consumer health reference
  • BBC News: Health
  • CNN Health: “Peptides: what to know about the wellness trend”
  • Sky News: “Can peptides make America healthy again?”
  • Sky News: “Inside the exploding US peptides craze” (video)
  • Sky News Australia: “Black market peptide trade explodes as influencers fuel uptick in use”
  • Sky News Australia: “Backyard peptide boom sparks alarm” (video)
  • Sky News Australia: “Oprah reveals struggle with shame of weight-loss drugs”

    • Key Characteristics

  • Synthetic seven-amino-acid fragment of Thymosin Beta-4
  • Acetylated N-terminus for stability (Ac-LKKTETQ)
  • Binds free G-actin 1:1 at submicromolar affinity
  • Broad tissue-repair spectrum in preclinical literature
  • Frequently co-studied with BPC-157 in preclinical tissue-repair literature
  • Subcutaneous Cmax 200-400 ng/mL in rodent PK studies
  • Research-grade purity target: >99% HPLC, batch dependent
  • Batch-specific third-party analysis available where provided

    • Specifications

    Compound Name TB-500 Parent Biology Thymosin Beta-4-derived actin-binding fragment Sequence Ac-LKKTETQ Expanded Sequence Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln Molecular Formula C 37 H 66 N 10 O 14 Molecular Weight 889.02 Da Purity Target >99% by HPLC, batch dependent Physical Form Lyophilised powder Half-life (SC) 1.5–3 h (rodent models) Solubility Soluble in sterile laboratory-grade aqueous solvents under appropriate research conditions Storage Store lyophilised material frozen and protected from light. Follow batch-specific handling documentation. Research Format Lyophilised peptide material for qualified laboratory research only. Not supplied for human or veterinary administration. Use Classification Research chemical. Not for human or veterinary use.

    About TB-500: Thymosin Beta-4 Fragment Research Guide

    TB-500 is one of the most commonly cited research peptides in soft-tissue repair literature. Rather than being a hormone or a typical growth factor, it is a short fragment of a large housekeeping protein (Thymosin Beta-4) that almost every cell in the body makes. Researchers reach for TB-500 when they want to study how cells migrate into damaged tissue without the complexity of handling the full 43-residue parent protein.

    Mechanistically, TB-500 does two things well: it regulates the available pool of building-block actin inside cells (which controls how they move and change shape), and it dampens the inflammatory master switch NF-κB. That combination is why injury models as different as tendon transection, myocardial infarction, and corneal abrasion all show improvement in TB-500 studies.

    New-U Research Compounds supplies TB-500 as a lyophilised powder with a purity target of >99% by HPLC. A batch-specific third-party Certificate of Analysis is provided per batch where available. All material is sold strictly for in-vitro and preclinical research and is not intended for human use. TB-500 is a WADA-prohibited substance for competing athletes.

    Research-only notice: this material is not for human consumption, injection, veterinary use, clinical treatment, diagnostic use, cosmetic use, or athletic performance enhancement.

  • Thymosin beta-4: general background (Wikipedia)
  • Actin: general background (Wikipedia)

    • Customer Reviews

    Smooth delivery

    Ordered TB-500 online from New-U and delivery was straight forward. Tracking worked, parcel arrived discreetly and the vial was sealed.

    — Rosa S**** · 30 June 2026

    Good product page detail

    The New-U TB-500 page gave the main details clearly before ordering. Lab-use wording, COA access and batch testing info were all visible.

    — Tomislav K**** · 30 June 2026

    More in Healing / Recovery

  • BPC-157
  • AOD-9604
  • KPV
  • Thymosin Alpha-1

    • TB-500 vs related Healing / Recovery compounds

    Compound Price Purity spec COA TB-500 from $50 >99% HPLC On request BPC-157 from $31 >99% HPLC 1 published batch AOD-9604 from $43 >99% HPLC 1 published batch
  • TB-500 vs BPC-157 — full comparison

    • Descriptive catalog comparison for research sourcing decisions — not dosing guidance. All compounds are for laboratory research use only.

    More on TB-500

  • TB-500 research guide
  • Buy TB-500 — pricing & packs

    • Research use only — not for human consumption. All products are supplied strictly for laboratory research purposes.

    © 2026 New-U Research Compounds · new-u.io — Copyright held with Hilxera Distribution Services LLC. All rights reserved.