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TB-500 peptide: Healing / Recovery research guide

In short: TB-500 research material supplied as full-length thymosin beta-4 (Tβ4), the 43-residue N-acetylated, actin-sequestering peptide encoded by the human TMSB4X gene. It is studied in preclinical (cell and animal) research and is supplied strictly for laboratory use, not for human or clinical use.

Not medical advice. TB-500 is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.

TB-500 at a glance

Compound type

Research peptide

Research category

Healing / Recovery

Also known as

Thymosin Beta-4, Thymosin β4, Tβ4, TB4, TB-500, Timbetasin, TMSB4X product

Molecular weight

4963 Da (average; C212H350N56O78S)

Research-grade purity

>99% HPLC

Evidence context

Preclinical / research use only

Regulatory status

Not an approved medicine. Supplied as a research compound

Last reviewed

14 October 2026

What to know first

Compound TB-500 Research class Healing / Recovery Catalog code TB5 Purity >99% HPLC Available pack sizes 10 × 2 mg, 10 × 5 mg, 10 × 10 mg, 10 × 20 mg, 10 × 30 mg, 10 × 40 mg, 10 × 50 mg, 10 × 60 mg Storage Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation.

Details and limits sit in the sections below. Research use only. No unsupported scientific claims are added here.

What TB-500 is

TB-500 (a Thymosin Beta-4–related fragment) is researched for actin -the cell’s internal scaffolding -and how cells move during repair. That makes it a frequent reference point in wound and soft-tissue injury science.

One-paragraph overview from our research datasheet. Still scientific, but faster to read than the full mechanism list below.

TB-500 research material supplied as full-length thymosin beta-4 (Tβ4), the 43-residue N-acetylated, actin-sequestering peptide encoded by the human TMSB4X gene.

Quick takeaways

Literature often ties it to angiogenesis (new vessel support) and anti-inflammatory signalling in preclinical models.

Researchers distinguish the short fragment from full-length thymosin peptides when discussing potency and stability.

Sold strictly for research -not for athletic, cosmetic, or medical use in humans.

Research contexts

Peer-reviewed papers discuss TB-500 in specific lab settings. The points below reflect research questions, not health claims.

Research vs. personal use: Literature describes experiments in cells and animals. That is distinct from real-world use. Our products are for laboratory research only.

Typical study contexts

Rodent wound and corneal models historically informed how thymosin beta-4–class biology is framed; modern fragment studies continue in similar preclinical lanes.

Papers emphasise actin dynamics and cell motility assays, useful for understanding why scientists group this peptide with “repair biology” in the lab.

Any real-world recovery stories you may encounter are not substitutes for peer-reviewed evidence or medical care.

Rodent and cell models of tendon, muscle, ligament or gut injury.

Wound-healing and blood-vessel assays after controlled damage.

Occasional case-style research write-ups. Not clinical proof.

Full-length 43-residue thymosin beta-4 sequence, listed in one-letter and three-letter code.

N-terminal acetylation matching the natural mature peptide (N-acetylserine, UniProt P62328).

Why Healing / Recovery research matters

These compounds show up in tissue-injury and wound models. Studies track cell movement, blood-vessel support and inflammation balance. They do not replace medical care.

Mechanisms (technical review)

Our datasheet lists mechanistic themes from preclinical work. These are research endpoints, not health claims.

Full-length 43-residue thymosin beta-4 sequence, listed in one-letter and three-letter code

N-terminal acetylation matching the natural mature peptide (N-acetylserine, UniProt P62328)

Contains the LKKTETQ actin-binding motif at residues 17-23

Described in the literature as the major actin-sequestering molecule of eukaryotic cells

Lab handling & preparation

Storage: Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation.. See the storage guide.

Published pharmacokinetic context: Laboratory research material. No amount, schedule or administration guidance is published or recommended on this page.

Preparation: Follow the reconstitution guide. Confirm volumes with the calculator.

Purity check: Use the COA reading guide and the published TB-500 Certificate of Analysis.

Common Questions People Are Asking

What is TB-500 on this site?

It is supplied as full-length thymosin beta-4 (Tβ4): a 43-amino-acid, N-acetylated peptide with the human sequence Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES (UniProt P62328).

Is this the 7-amino-acid LKKTETQ fragment?

No. LKKTETQ (residues 17-23) is the central actin-binding motif inside the 43-residue peptide. The product is the whole chain, not that segment.

What is the molecular weight and formula?

PubChem lists thymosin beta 4 (CID 45382195) with the formula C212H350N56O78S and an average molecular weight of 4963 Da.

Is the peptide acetylated?

Yes. UniProt P62328 records N-acetylserine at the first residue of the mature chain after the initiator methionine is removed.

What does the literature say about its biology?

Reviews describe Tβ4 as the major actin-sequestering molecule of eukaryotic cells, with the central actin-binding domain at residues 17-23 and the Ac-SDKP site at the N-terminus. These are laboratory descriptions, not statements about human effects.

Are there human data?

No controlled human data are cited on this page, and human safety is not established.

Does New-U give dosing or administration guidance?

No. This material is for laboratory research only and no amount, schedule or administration guidance is published.

Is TB-500 approved for human use?

No approval for human use is claimed. It is sold as a research chemical, not for human or veterinary use.

How should the research material be stored?

Store the lyophilised powder frozen and protected from light, and follow the batch-specific handling documentation.

What vial sizes are offered?

New-U lists TB-500 as 10-vial packs at 2 mg, 5 mg, 10 mg, 20 mg, 30 mg, 40 mg, 50 mg or 60 mg per vial, and as single sample vials at 5 mg and 10 mg; see the pricing table on this page.

Is this page medical advice? Can I use TB-500 for my health?

No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.

Where do I find TB-500 specs, purity certificates and pricing?

Open the shop listing via “View product details.” There you will see batch specs, the Certificate of Analysis (COA), concentration, purity grade, and available SKUs with current pricing.

Related peptide guides

Other compounds researchers often read about alongside TB-500.

BPC-157: Healing / Recovery research guide

AOD-9604: Healing / Recovery research guide

KPV: Healing / Recovery research guide

Thymosin Alpha-1: Healing / Recovery research guide

Continue TB-500 research

Analytical evidence, comparisons and current research for this compound. Research use only.

Analytical evidence View the TB-500 COA Latest published certificate of analysis (purity and identity), dated 2026-01-29. View the COA →

Compare Compare TB-500 and BPC-157 TB-500 vs BPC-157: mechanism, receptor profile and specifications side by side. Compare →

Research area Tissue repair & recovery research The tissue-repair research area - cytoprotective and growth-factor peptides studied in wound healing, tendon, muscle and gut-lining… Explore the research area →

Scientific sources & further reading

Primary literature and registries for TB-500, plus mainstream coverage of the peptide category. Research use only - not medical advice.

Databases & literature:

PubMed: peer-reviewed literature on TB-500

ClinicalTrials.gov: registered studies on TB-500

TB-500: Wikipedia

Peptides in the news:

WebMD: consumer health reference

BBC News: Health

CNN Health: “Peptides: what to know about the wellness trend”

Sky News: “Can peptides make America healthy again?”

Sky News: “Inside the exploding US peptides craze” (video)

Sky News Australia: “Black market peptide trade explodes as influencers fuel uptick in use”

Sky News Australia: “Backyard peptide boom sparks alarm” (video)

Sky News Australia: “Oprah reveals struggle with shame of weight-loss drugs”

Ready to order? View full product specs

Access concentration, batch info, variants, and current pricing on our shop.

Also known as: Thymosin Beta-4, Thymosin β4, Tβ4, TB4, TB-500, Timbetasin, TMSB4X product

PRECISION. PURITY. PERFORMANCE.

Research peptides. Third-party Certificates of Analysis (Janoshik Analytical & Freedom Diagnostics) are published on the website. Supplied strictly for laboratory research use.

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