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  • How-to guides
    New-U Research Compounds — Buy TB-500 at New-U Research Compounds. Laboratory research use only.

    Regenerative Research · Reviewed 14 October 2026

    Buy TB-500

    Also known as Thymosin Beta-4, Thymosin β4, Tβ4, TB4, Timbetasin, TMSB4X product

    TB-500 research material supplied as full-length thymosin beta-4 (Tβ4), the 43-residue N-acetylated, actin-sequestering peptide encoded by the human TMSB4X gene.

    $119 10-vial pack · 2mg · in stock

    Single vials from $50 (order minimum: 5 single vials, or any 10-vial peptide pack).

  • View full research profile
  • Compare all 10 formats
  • Certificate of Analysis
  • For laboratory and research use only — not for human or veterinary use. 21+.

    Inside New-U Research Compounds

    TB-500 at a glance

    Sequence
    Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
    Molecular weight
    4963 Da (average; C212H350N56O78S)
    Pathways studied
    G-actin binding · Actin-binding motif (residues 17-23) · N-terminal Ac-SDKP region · Reported gene-expression effects
    Purity
    >99% HPLC
    Form
    Lyophilised powder
    Formats
    10-vial research packs and single vials · 2–60 mg per vial
    Latest certificate
    Janoshik Analytical, 29 January 2026 — 99.741% purity
    Laboratory storage
    Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation.

    What is TB-500?

    TB-500 is supplied as full-length thymosin beta-4 (Tβ4), a 43-amino-acid N-acetylated peptide encoded by the human TMSB4X gene.

    What TB-500 research examines

  • Full-length 43-residue thymosin beta-4 sequence, listed in one-letter and three-letter code
  • N-terminal acetylation matching the natural mature peptide (N-acetylserine, UniProt P62328)
  • Contains the LKKTETQ actin-binding motif at residues 17-23
  • Described in the literature as the major actin-sequestering molecule of eukaryotic cells
  • Summarised from published preclinical and clinical literature; findings describe study models, not uses of the research material.

    TB-500 price and pack sizes

    Strength per vial Format Price Cost per mg 2 mg 10-vial research pack $119 $5.95 5 mg 10-vial research pack $167 $3.34 5 mg Single vial $50 $10.00 10 mg 10-vial research pack $234 $2.34 10 mg Single vial $70 $7.00 20 mg 10-vial research pack $445 $2.23 30 mg 10-vial research pack $556 $1.85 40 mg 10-vial research pack $667 $1.67 50 mg 10-vial research pack $834 $1.67 60 mg 10-vial research pack $945 $1.57

    All packs are >99% HPLC research-grade material. Cost per mg is the price divided by the total mg in the pack. Single vials are also listed; an order needs at least 5 eligible single vials in total, or any 10-vial peptide pack. Standard delivery fee $35 USD, free over $350 USD; some destinations differ and the exact charge is shown at checkout.

    Current TB-500 certificate

    The current published certificate for TB-500 is an independent Janoshik Analytical report dated 29 January 2026.

    Laboratory Janoshik Analytical Report date 29 January 2026 Purity 99.741% Report number 101943
  • View the TB-500 certificate and testing history
  • Download the report (PDF)
  • How to read a Certificate of Analysis
  • Certificates of Analysis are published on the website — on each product page and at /coa — rather than packed with orders. Batch analysis reports identity and purity for the sample tested. It does not establish sterility, endotoxin or heavy-metal status, pharmaceutical equivalence, or any clinical property.

    Mechanism summary

    In the cited literature, Tβ4 binds monomeric actin through a central motif and has been associated with several cell-level activities attributed to separate regions of the peptide.

    Target or pathway Reported activity Research significance G-actin binding Binds monomeric actin; described as the major actin-sequestering molecule of eukaryotic cells Relevant to how the pool of polymerisable actin is regulated in cells Actin-binding motif (residues 17-23) LKKTETQ is the central actin-binding domain UniProt records that substitutions at residues 12, 16 and 18 weaken actin binding in mutagenesis work N-terminal Ac-SDKP region Residues 1-4 of the mature chain form the tetrapeptide Ac-SDKP Examined in the literature as a separate active site Reported gene-expression effects Review literature lists induction of laminin-5, MMPs, TGF-beta and zyxin expression Reported in cell systems; not localised to a single region of the peptide

    Pharmacokinetics at a glance

    Half-life Not stated; no figure is cited for the full-length peptide on this page Metabolism Not stated; no figure is cited on this page

    Average molecular weight 4963 and formula C212H350N56O78S are PubChem values for thymosin beta 4 (CID 45382195). UniProt describes the chain as disordered.

    Evidence summary

    Evidence base: Tier 2: Animal / preclinical

    The sources cited on this page are laboratory and review literature. No controlled human data are cited here, and no regulator approval for human use is claimed.

    Animal and laboratory studies

  • Malinda et al., Journal of Investigative Dermatology, 1999 (PMID 10469335): thymosin beta4 wound-healing experiments in animal models
  • Buying TB-500: ordering and delivery

    Delivery time
    Approximately 6–14 business days worldwide
    Dispatch
    Orders typically dispatch within 48 hours of confirmed payment.
    Ships from
    US orders ship from the USA or China depending on stock and fulfilment; all other destinations ship from China, direct from the manufacturer.
    Shipping cost
    Standard delivery fee $35 USD, free over $350 USD; some destinations differ and the exact charge is shown at checkout
    Payment
    Card, Apple Pay, Google Pay, Cash App, Cryptocurrency
    Packaging
    Discreet packaging
    In transit
    Lyophilised peptides are stable through the tracked transit window.
    Purchasers
    21+ · laboratory research use only

    Explore TB-500 research

    Published research, analytical evidence and comparisons for this compound. Research use only.

  • Research guide TB-500 research guide In the cited literature, Tβ4 binds monomeric actin through a central motif and has been associated with several cell-level activities… Read the guide →
  • Analytical evidence View the TB-500 COA Latest published certificate of analysis (purity and identity), dated 2026-01-29. View the COA →
  • Compare Compare TB-500 and BPC-157 TB-500 vs BPC-157: mechanism, receptor profile and specifications side by side. Compare →
  • Related research BPC-157 and TB-500 under FDA review: why regenerative peptide research is entering a new era BPC-157 and TB-500 are scheduled for FDA advisory committee discussion on July 23, 2026 (evaluated uses: ulcerative colitis and wound… Read the article →
  • Related research FDA peptide review 2026: what the July meeting could mean for BPC-157, TB-500, Semax and Epitalon The FDA's Pharmacy Compounding Advisory Committee reviews BPC-157, KPV, TB-500, MOTS-c, Emideltide (DSIP), Semax and Epitalon on July… Read the article →
  • Frequently asked questions

    Where can I buy TB-500?

    TB-500 (also known as Thymosin Beta-4) is available directly from New-U Research Compounds at https://new-u.io/peptide/tb-500. It is supplied as lyophilised research-grade material; every released sale batch is independently verified by Janoshik Analytical and Freedom Diagnostics before it is offered for sale, and orders ship direct from source worldwide (approximately 6–14 business days).

    How much does TB-500 cost?

    TB-500 starts at $119 for a 10-vial research pack (2mg per vial) at New-U Research Compounds, with 10 pack sizes listed; single vials from $50 are also listed (an order needs at least 5 eligible single vials in total, or any 10-vial peptide pack). Orders over $350 ship free.

    Is New-U TB-500 third-party tested?

    Yes. Released TB-500 batches are verified by independent laboratories (Janoshik Analytical and Freedom Diagnostics) for identity and purity before they are offered for sale. The current published certificate (Janoshik Analytical, 29 January 2026) reports 99.741% purity and is published at https://new-u.io/coa/tb-500.

    How fast does TB-500 ship, and do you ship internationally?

    TB-500 ships discreetly and tracked worldwide. US orders ship from the USA or China depending on stock and fulfilment; all other destinations ship from China, direct from the manufacturer. Delivery takes approximately 6–14 business days worldwide. Shipping is free on orders over $350. Card and cryptocurrency payments are accepted.

    Is it legal to buy TB-500?

    In the United States, TB-500 is not approved by the FDA for human consumption and is not sold for that purpose. Research use only - all claims made on this site are for testing and research use only. Regulatory requirements vary by product, intended use and jurisdiction. Purchasers are responsible for ensuring that acquisition and use of research material complies with applicable requirements.

    What is TB-500 used for in research?

    TB-500 research material supplied as full-length thymosin beta-4 (Tβ4), the 43-residue N-acetylated, actin-sequestering peptide encoded by the human TMSB4X gene. New-U supplies TB-500 as research-grade reference material for laboratory and in-vitro or animal-model investigation only. Mechanism, pharmacokinetics and study context are summarised on the TB-500 research profile.

    What is the typical TB-500 research dosage?

    Reconstitution volumes and dosing reported in the literature for TB-500 are described in research-model terms only. New-U Research Compounds supplies TB-500 strictly for laboratory research and does not provide human-use dosing guidance. Reconstitution math and study-reported ranges are covered on the full research profile.

    What do I use to reconstitute TB-500?

    Lyophilised TB-500 is reconstituted with bacteriostatic water - sterile water with 0.9% benzyl alcohol, the standard multi-use diluent for research peptides. New-U supplies USP-grade bacteriostatic water at https://new-u.io/peptide/bacteriostatic-water, and a free reconstitution calculator at https://new-u.io/tracker/calculator works out the volume for any peptide.

    Can I buy TB-500 online and how fast does it ship?

    Yes. TB-500 can be ordered online directly from New-U Research Compounds with card or cryptocurrency, shipped direct from source discreetly worldwide. Delivery is approximately 6–14 business days worldwide. Free shipping applies to orders over $350.

    Can I buy TB-500 in bulk?

    TB-500 ships in 10-vial research packs as standard, in 10 pack sizes — the larger mg vials lower the per-mg cost. Multi-pack orders get direct-from-source pricing and free shipping over $350. For wholesale or recurring laboratory-supply volumes, contact New-U Research Compounds at https://new-u.io/contact.

    What should I look for when choosing where to buy TB-500?

    For research-grade TB-500, verify four things: (1) independent third-party purity testing with a published Certificate of Analysis - New-U uses Janoshik Analytical and Freedom Diagnostics; (2) lyophilised material with documented storage and handling; (3) transparent direct-from-source pricing rather than marketplace markup; and (4) clear research-use-only framing. New-U Research Compounds meets all four at https://new-u.io/peptide/tb-500, and the current TB-500 certificate is at https://new-u.io/coa/tb-500.

    Can I buy TB-500 and BPC-157 together (the "Wolverine stack")?

    Yes. New-U Research Compounds supplies both TB-500 and BPC-157 as separate research-grade vials. They are studied together because they support tissue repair through different mechanisms - TB-500 through actin regulation, angiogenesis, and NF-κB modulation, and BPC-157 through the VEGFR2/eNOS pathway and growth-hormone-receptor upregulation. Order TB-500 at https://new-u.io/peptide/tb-500 and BPC-157 at https://new-u.io/peptide/bpc-157.

    What is TB-500 on this site?

    It is supplied as full-length thymosin beta-4 (Tβ4): a 43-amino-acid, N-acetylated peptide with the human sequence Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES (UniProt P62328).

    Is this the 7-amino-acid LKKTETQ fragment?

    No. LKKTETQ (residues 17-23) is the central actin-binding motif inside the 43-residue peptide. The product is the whole chain, not that segment.

    What is the molecular weight and formula?

    PubChem lists thymosin beta 4 (CID 45382195) with the formula C212H350N56O78S and an average molecular weight of 4963 Da.

    Is the peptide acetylated?

    Yes. UniProt P62328 records N-acetylserine at the first residue of the mature chain after the initiator methionine is removed.

    What does the literature say about its biology?

    Reviews describe Tβ4 as the major actin-sequestering molecule of eukaryotic cells, with the central actin-binding domain at residues 17-23 and the Ac-SDKP site at the N-terminus. These are laboratory descriptions, not statements about human effects.

    Are there human data?

    No controlled human data are cited on this page, and human safety is not established.

    Does New-U give dosing or administration guidance?

    No. This material is for laboratory research only and no amount, schedule or administration guidance is published.

    Is TB-500 approved for human use?

    No approval for human use is claimed. It is sold as a research chemical, not for human or veterinary use.

    How should the research material be stored?

    Store the lyophilised powder frozen and protected from light, and follow the batch-specific handling documentation.

    What vial sizes are offered?

    New-U lists TB-500 as 10-vial packs at 2 mg, 5 mg, 10 mg, 20 mg, 30 mg, 40 mg, 50 mg or 60 mg per vial, and as single sample vials at 5 mg and 10 mg; see the pricing table on this page.

    Research references

    Independent literature and reference sources for TB-500. Provided for scientific context - New-U Research Compounds supplies research-use-only material.

  • TB-500 — Wikipedia
  • Looking for mechanism of action, pharmacokinetics, dosage ranges and source references? See the full TB-500 research profile. Every compound profile is listed in the research peptide index.

    Part of the Tissue repair & recovery research research area — explore related compounds, guides and sources.

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    Research peptides. Third-party Certificates of Analysis (Janoshik Analytical & Freedom Diagnostics) are published on the website. Supplied strictly for laboratory research use.

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  • Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.

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    © 2026 New-U Research Compounds · new-u.io

    [image: New-U Research Compounds logo and research peptide vial — Buy TB-500 at New-U Research Compounds]

    [image: TB-500 research peptide vial — Healing / Recovery compound, >99% HPLC]

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