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  • Ipamorelin

    • Ipamorelin

    Ipamorelin, first selective growth hormone secretagogue with GHRH-like GH specificity and no significant ACTH, cortisol, or prolactin stimulation.

    This strength is out of stock. Pick another strength, or check back soon — restocks are frequent.

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    Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.

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    • Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.

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    Ipamorelin

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    Lab-direct quality — full packs or single-vial samples

    Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a published batch Certificate of Analysis. View the batch Certificate of Analysis → Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.

    Order a sealed 10-vial research pack , or add a single-vial laboratory sample alongside your pack to evaluate a compound at smaller scale first. Same lab, same batch, same verified purity — scaled to whatever your research needs.

    What It's Researched For

    In plain terms, ipamorelin is the cleanest, most selective compound studied for prompting natural growth-hormone release. Here is what that looks like across the research.

    Clean GH release

    Research explores how it triggers a growth-hormone pulse without the stress-hormone, appetite or prolactin side signals seen with similar peptides.

    Muscle & lean mass

    Studied for how the resulting growth hormone and IGF-1 support lean body mass and protein building.

    Fat & body composition

    Animal research examines shifts in body composition that follow a clean, pulse-like growth-hormone signal.

    Sleep-timed dosing

    Often studied at bedtime so the induced pulse lines up with the natural overnight growth-hormone surge.

    Paired research

    The standard partner for GHRH compounds like CJC-1295 or sermorelin, where two switches combine for a larger growth-hormone pulse.

    Overview

    In short: Ipamorelin is the most selective growth hormone secretagogue ever identified - a five-amino-acid ghrelin receptor agonist that releases GH without measurable increases in cortisol, ACTH, or prolactin.

    Key research facts

  • First-in-class selective GHS-R1a agonist with GH specificity matching GHRH, no cortisol or ACTH elevation
  • Does not stimulate prolactin secretion distinguishing it from hexarelin, GHRP-2, and GHRP-6
  • In vitro EC50 of 1.3 nM for pituitary GH release comparable to GHRP-6 potency
  • Activates phospholipase C/IP3/calcium cascade selectively on somatotroph cells
  • Synergistic GH amplification when combined with GHRH analogues (CJC-1295, sermorelin)

    • These points summarise lab themes, not human outcomes.

    Ipamorelin is a short pentapeptide developed by Novo Nordisk in the late 1990s. Its claim to fame is unusual specificity: it activates the ghrelin receptor (GHS-R1a) on pituitary somatotrophs to release GH, but unlike every other GHRP that came before it, it leaves the HPA axis alone. Even at doses hundreds of times above the GH-releasing threshold, cortisol and ACTH stay flat.

    That selectivity makes ipamorelin the cleanest tool for studying GH release through the ghrelin receptor in isolation. Researchers use it as a standalone compound for pulsatile GH research and as a reliable stack partner for GHRH analogs like CJC-1295 no DAC or sermorelin.

    Ipamorelin reached Phase II clinical trials for postoperative ileus (where its GI motility effects were being explored) and is supplied here as sterile lyophilised powder for in-vitro and preclinical research.

    Mechanism of Action

    Ipamorelin is a highly selective ghrelin receptor agonist that triggers GH release on somatotrophs without activating the corticotroph or lactotroph pathways that other GHRPs hit.

    Pathway Effect Why it matters GHS-R1a (ghrelin receptor) Full agonist on pituitary somatotrophs Drives GH exocytosis via the PLC / IP3 / calcium cascade No ACTH / cortisol activation Leaves corticotroph signalling unaffected Avoids the HPA stress response seen with hexarelin and GHRP-6 No prolactin release Does not engage lactotroph signalling Unique among early ghrelin-receptor peptides GHRH synergy Combines with GHRH analogs for supra-additive GH release Standard research pairing with CJC-1295 no DAC and sermorelin Short half-life ~2 hour terminal elimination Produces a sharp pulse suitable for physiologic research protocols Deeper dive for scientific readers

    Raun et al. (European Journal of Endocrinology, 1998) described ipamorelin as the first ghrelin-receptor agonist with GH selectivity comparable to GHRH itself - releasing GH without significant ACTH, cortisol, or prolactin even at doses >200-fold above the GH-releasing ED50. In-vitro EC50 for GH release is ~1.3 nM, similar to GHRP-6, but without the secondary pituitary effects. Gobburu et al. (Pharmaceutical Research, 1999) reported terminal t½ ~2 h, clearance 0.078 L/h/kg, Vd 0.22 L/kg, and SC bioavailability ~95%. A striking 60-80% of the dose is recovered as intact peptide in urine and bile.

    Common Questions People Are Asking

    What is ipamorelin?

    Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) that selectively activates the ghrelin/growth-hormone-secretagogue receptor (GHSR), prompting the pituitary to release growth hormone. It is one of the most selective GH secretagogues studied and is supplied as a lyophilised research-grade powder.

    What does ipamorelin do?

    In research models ipamorelin stimulates a clean, pulse-like release of growth hormone from the pituitary by acting on the GHSR receptor - without the cortisol, ACTH or prolactin spikes seen with GHRP-2/GHRP-6. These are findings in cell and animal models; no human therapeutic effect is implied.

    What is ipamorelin used for?

    In the research literature ipamorelin is used as a tool compound to study the growth-hormone axis, GH/IGF-1 signalling, body-composition and recovery endpoints, often alongside a GHRH analogue such as CJC-1295. New-U supplies it strictly for in-vitro and animal-model research.

    Is ipamorelin safe?

    In published animal studies ipamorelin has been well tolerated with a notably selective profile (minimal cortisol/prolactin effect), but there are no controlled human safety trials, so human safety is not established.

    Is ipamorelin FDA approved?

    No. Ipamorelin is an investigational research peptide and is not approved by the FDA, EMA, or any other regulator for human therapeutic use. It is sold strictly for preclinical and in-vitro research.

    Why is ipamorelin considered "cleaner" than GHRP-2 or GHRP-6?

    GHRP-2 and GHRP-6 both activate the ghrelin receptor but also trigger noticeable increases in cortisol, ACTH, and prolactin at GH-releasing doses. Ipamorelin does not - even at doses hundreds of times above its GH-releasing threshold, those secondary pituitary effects remain flat.

    Can ipamorelin be combined with CJC-1295?

    Yes - this is the most common research stack in the GHRP family. Ipamorelin activates the ghrelin receptor while CJC-1295 activates the GHRH receptor, and the two mechanisms produce supra-additive GH release. The pairing is used to mimic physiologic pulsatile GH secretion.

    Does ipamorelin cause hunger like GHRP-6?

    Ipamorelin produces far weaker orexigenic effects than GHRP-6 in comparative studies. Its ghrelin-receptor selectivity is tuned toward somatotroph activation rather than hypothalamic appetite signalling, so appetite stimulation is typically minimal in research protocols.

    Does ipamorelin affect sleep?

    A large share of the body's natural growth-hormone output occurs during deep, slow-wave sleep, which is why ipamorelin is frequently studied with pre-sleep timing - to line its short, clean GH pulse up with that nocturnal surge. The GH/IGF-1 axis is closely tied to slow-wave sleep in the literature, so sleep-quality and recovery endpoints are common in research designs. These are research-context observations.

    How should ipamorelin be stored?

    Keep the lyophilised powder frozen at −20 °C until reconstitution. After mixing with bacteriostatic water, refrigerate at 1-6 °C and protect from light. Ipamorelin is stable in solution within the normal peptide-handling window.

    How much does ipamorelin cost?

    Research-grade ipamorelin is priced per vial and sold by New-U in sealed 10-vial research packs, with the per-mg cost falling on larger vials. Every pack is >99% HPLC-verified with a batch-linked Certificate of Analysis. See the New-U ipamorelin page for current per-vial pricing.

    What does a CJC-1295 + ipamorelin research cycle cost per month?

    The most-studied GH-axis pairing combines ipamorelin (a ghrelin-receptor agonist) with CJC-1295 (a GHRH analogue). Monthly research cost depends on the amounts and frequency a protocol uses for each vial; because both are sold in 10-vial packs at per-vial pricing, larger vials lower the per-mg cost of the pairing. New-U publishes per-vial pricing on each product page - this is research-supply cost context, not a human-use dosing or cost recommendation.

    What ipamorelin dosage is used in research?

    Published research protocols describe microgram-range subcutaneous amounts, often once to a few times daily, sometimes timed to the natural nocturnal GH pulse. New-U publishes this as descriptive research context only - it is not a dosing instruction.

    What effects are studied with ipamorelin?

    Ipamorelin is studied for selective growth-hormone release and downstream GH/IGF-1-axis endpoints (body composition, recovery, sleep) without the cortisol, prolactin or strong appetite signals seen with GHRP-6. These are research findings; New-U makes no therapeutic claims.

    How does ipamorelin compare to sermorelin and hexarelin?

    All three raise growth hormone but through different receptors/scaffolds: ipamorelin is a clean, selective ghrelin-receptor (GHSR) agonist; sermorelin is a GHRH analogue acting upstream on the pituitary; hexarelin is a more potent GHRP-6-type GHSR agonist with added CD36 cardiac activity but more cortisol/prolactin. See our Ipamorelin vs Sermorelin and Hexarelin vs Ipamorelin research comparisons for the full breakdown.

    What happens if you stop taking peptides?

    For growth-hormone-secretagogue peptides such as ipamorelin, the published research is informative: these compounds work by transiently stimulating the body's own GH pulses rather than replacing a hormone, so when administration stops the endogenous GH/IGF-1 axis returns toward its untreated baseline without the prolonged suppression seen after exogenous HGH. Effects observed during a study taper off as the short-acting peptide clears. These are research-model observations - ipamorelin is supplied for laboratory research only and is not for human use.

    Where can I buy Ipamorelin?

    Right here - Ipamorelin is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.

    Is Ipamorelin third-party tested?

    Yes. Every Ipamorelin batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.

    How do I buy Ipamorelin?

    Add the Ipamorelin pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step. Every order ships with its batch Certificate of Analysis (COA).

    What payment methods can I use to buy Ipamorelin?

    At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.

    How fast is shipping, and do you ship worldwide?

    Yes - we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.

    Is it legal to buy Ipamorelin?

    In the United States, Ipamorelin is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction - buyers are responsible for compliance in their own region.

    Research use only - all claims made on this site are for testing and research use only.

    Pharmacokinetics

    Half-life ~2 h terminal elimination half-life; GH peak (Tmax) ~40 min Absorption route Subcutaneous (~95% bioavailability); intranasal ~20% Bioavailability Subcutaneous ~95%; intranasal ~20% Metabolism / clearance Moderate metabolic resistance - 60–80% recovered as intact peptide in urine/bile; clearance 0.078 L/h/kg; Vd 0.22 L/kg Stability Lyophilised: −20 °C. Reconstituted: 1–6 °C, protect from light Notes PK characterised by Gobburu et al. (Pharm Res, 1999); the short half-life produces a sharp GH pulse well suited to physiologic research protocols.

    Research-Observed Effects

  • Selective GH release with no significant ACTH, cortisol, or prolactin elevation even >200× the GH-releasing ED50 (Raun 1998)
  • In-vitro EC50 ~1.3 nM for pituitary GH release (comparable to GHRP-6) without the secondary pituitary effects
  • Supra-additive GH pulse when combined with a GHRH analogue (CJC-1295, sermorelin)
  • Sharp ~2 h GH pulse; pre-sleep timing amplifies the natural nocturnal surge
  • Favourable tolerability in Phase II clinical work (postoperative ileus)

    • Published Research Context

    The research literature describes microgram-range subcutaneous amounts, often once to a few times daily and frequently timed to the natural nocturnal GH pulse or paired with a GHRH analogue. These are experimental parameters from research settings, recorded as context only.

    Stacking Compatibility

    Compatible compounds

  • CJC-1295 (no DAC): Ghrelin-receptor + GHRH-receptor co-activation gives a supra-additive, physiologic GH pulse - the standard research pairing
  • CJC-1295 (with DAC): Long-acting GHRH partner for sustained-elevation research designs
  • Sermorelin: Shorter GHRH(1-29) analogue partner for pulsatile GH research
  • Tesamorelin: GHRH-analogue partner with the strongest clinical dataset

    • Avoid combinations

  • GHRP-2 / GHRP-6 / Hexarelin (other ghrelin-receptor agonists): Redundant GHSR occupancy and reintroduces the cortisol/prolactin effects ipamorelin avoids
  • Exogenous recombinant GH: Direct GH dosing suppresses the endogenous axis the secretagogue is meant to stimulate

    • Side Effects (Observed in Literature)

    Common

  • Injection-site reactions (redness, itching)
  • Transient flushing or head-rush after injection

    • Rare

  • Mild water retention or headache
  • Minimal appetite stimulation (much weaker than GHRP-6)

    • Dose-dependent

  • GH-related effects scale with dose; the GH selectivity (no cortisol/prolactin rise) is preserved even at high doses

    • Evidence Tier

    Overall: Tier 2: Animal / preclinical

    Ipamorelin has strong mechanistic and animal data plus early-phase human tolerability work, but no approved therapeutic indication. Supplied as unapproved research-grade material.

    Tier 1 · Human clinical

  • Phase II clinical tolerability work in postoperative ileus (GI-motility endpoint)

    • Tier 2 · Animal

  • Raun et al. Eur J Endocrinol 1998 - selectivity and in-vivo GH-release potency (swine/in-vitro)
  • Gobburu et al. Pharm Res 1999 - pharmacokinetics

    • Certificates, databases & peer-reviewed sources

    Last reviewed: 16 June 2026 · New-U Research Compounds

  • Raun K et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. · 1998 · PMID: 9849822 · DOI: 10.1530/eje.0.1390552
  • Gobburu JVS et al. Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharm Res. · 1999
  • PubMed: peer-reviewed literature on Ipamorelin
  • ClinicalTrials.gov: registered studies on Ipamorelin
  • Ipamorelin: Wikipedia
  • WebMD: consumer health reference
  • BBC News: Health
  • CNN Health: “Peptides: what to know about the wellness trend”
  • Sky News: “Can peptides make America healthy again?”
  • Sky News: “Inside the exploding US peptides craze” (video)
  • Sky News Australia: “Black market peptide trade explodes as influencers fuel uptick in use”
  • Sky News Australia: “Backyard peptide boom sparks alarm” (video)
  • Sky News Australia: “Oprah reveals struggle with shame of weight-loss drugs”

    • Key Characteristics

  • Five-amino-acid pentapeptide (Aib-His-D-2Nal-D-Phe-Lys-NH₂)
  • Most selective GHRP ever characterised
  • No measurable ACTH, cortisol, or prolactin elevation
  • Developed by Novo Nordisk (NNC 26-0161)
  • Terminal half-life ~2 h, SC bioavailability ~95%
  • Typical research dose 100-300 mcg subcutaneously
  • Standard stack partner for CJC-1295 / sermorelin
  • Research-grade purity: >99% HPLC

    • Specifications

    Molecular Formula C 38 H 49 N 9 O 5 Molecular Weight 711.85 Da Sequence Aib-His-D-2-Nal-D-Phe-Lys-NH 2 Purity >99% (HPLC) Form Lyophilised powder Half-life ~2 h (terminal) Bioavailability (SC) ~95% Route Subcutaneous injection, typically pre-sleep Storage Lyophilised: −20 °C freezer. Reconstituted: 1-6 °C, away from light.

    About Ipamorelin: Selective Ghrelin-Receptor GH Secretagogue Research Guide

    Ipamorelin (NNC 26-0161) belongs to the GHRP (growth hormone releasing peptide) family, but it is fundamentally cleaner than the compounds that preceded it. When Raun and colleagues at Novo Nordisk first described it in 1998, the striking observation was not just that it released GH - the whole GHRP class does that - but that it released GH without engaging the corticotroph or lactotroph axes at any dose they tested, sparing the cortisol and prolactin spikes seen with GHRP-2 and GHRP-6.

    That specificity turned ipamorelin into the reference pentapeptide for anyone wanting to study GHSR-mediated GH release in isolation. It is also why it became the most popular stack partner for GHRH analogs like CJC-1295 no DAC: combining ipamorelin with a GHRH peptide produces a supra-additive GH pulse through two complementary receptors, with no cortisol or prolactin baggage.

    New-U Research Compounds supplies ipamorelin as a research-grade lyophilised powder at >99% HPLC purity, verified by independent third-party labs. All material is strictly for in-vitro and preclinical research use. Ipamorelin is not approved for human therapeutic use, and nothing on this page is medical advice.

  • Ipamorelin - Wikipedia
  • Growth hormone secretagogue receptor - Wikipedia
  • Ghrelin - Wikipedia
  • Growth hormone - Wikipedia

    • Customer Reviews

    Good condition for receiving

    Lab-handling note: Ipamorelin arrived tidy with clear labelling and intact seals — a good fit for GH-axis research material records.

    - Alejandro V***** · 30 August 2026

    Arrived sealed and tidy

    Ipamorelin arrived sealed and easy to catalogue, with clear batch, variant and COA details and visible research-use-only wording.

    - Lucia B****** · 30 August 2026

    More in HGH / Somatropin

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  • Sermorelin
  • CJC-1295 (with DAC)
  • CJC-1295 (without DAC)
  • Hexarelin
  • GHRP-2

    • Ipamorelin vs related HGH / Somatropin compounds

    Compound Price Purity spec COA Ipamorelin from $119 >99% HPLC 1 published batch Tesamorelin from $172 >99% HPLC 1 published batch Sermorelin from $164 >99% HPLC On request
  • Ipamorelin vs Tesamorelin - full comparison
  • Ipamorelin vs Sermorelin - full comparison

    • Descriptive catalog comparison for research sourcing decisions - not dosing guidance.

    More on Ipamorelin

  • Ipamorelin research guide
  • Buy Ipamorelin - pricing & packs

    • Part of the Growth hormone secretagogue research research area — explore related compounds, guides and sources.

    Research use only — not for human consumption. All products are supplied strictly for laboratory research purposes.

    © 2026 New-U Research Compounds · new-u.io — Copyright held with Hilxera Distribution Services LLC. All rights reserved.