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CJC-1295 (without DAC)
Pick your pack · how long it lasts
At 1.40 mg/wk — select pack size
1 × 10-vial pack required for packing — samples add on to any pack
Lab-direct quality — full packs or single-vial samples
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a batch-linked Certificate of Analysis. Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a full sealed 10-vial research pack for a complete study supply, or add a single-vial sample alongside your pack to trial a new compound first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
In plain terms, CJC-1295 without DAC is the short-acting version studied for sharp, natural growth-hormone pulses rather than week-long elevation. Here is what that looks like across the research.
Natural GH pulses
Animal and mechanistic studies explore how its short, roughly half-hour action produces a sharp growth-hormone pulse, close to what the body does on its own.
Stacked research
Most often studied paired with ipamorelin, where the two work through different switches to amplify a single combined growth-hormone pulse.
Muscle & recovery
Preclinical research looks at how repeated natural-shaped pulses support lean mass and recovery through downstream IGF-1.
Sleep-timed dosing
Studied with pre-sleep or pre-training timing so the induced pulse lines up with the body's own growth-hormone rhythm.
Avoiding burnout
Early research notes that short pulses keep the system responsive, unlike a constant signal that can blunt the response over time.
Overview
CJC-1295 without DAC (Modified GRF 1-29) is a short-acting tetrasubstituted GHRH analog that produces clean, physiologic growth hormone pulses without the week-long albumin-bound tail of the DAC version.
Modified GRF 1-29 is the sermorelin scaffold with four strategic substitutions (D-Ala2, Gln8, Ala15, Leu27). Those changes block the three ways the native peptide usually gets inactivated - DPP-IV cleavage, asparagine rearrangement, and methionine oxidation - and bump GH release area-under-curve about 4x above unmodified GHRH(1-29).
Unlike its DAC-bearing sibling, this version has no albumin-binding chemistry. Half-life is roughly 30 minutes, which is the point: researchers want a sharp, pulsatile GH signal that mimics what the hypothalamus would do naturally, not a continuous elevation.
CJC-1295 no DAC is the most commonly stacked GHRH analog in peptide research, especially paired with a ghrelin-receptor agonist like ipamorelin or GHRP-2. Supplied here as sterile lyophilised powder for in-vitro and preclinical research.
Mechanism of Action
Mod GRF 1-29 activates the GHRH receptor to produce a short, natural-shaped pulse of growth hormone, synergising with ghrelin-receptor peptides.
The four substitutions were originally described by Jette et al. (Endocrinology, 2005), who showed they increased GH release AUC roughly four-fold versus unmodified GHRH(1-29) while preserving the short functional half-life (~30 min). This short duration is actually a feature: GHRH receptors desensitise with sustained stimulation, and a pulsatile signal maintains responsiveness over time. Somatostatin feedback remains intact, so the natural off-switch still shapes each pulse. (The covalently albumin-bound DAC sibling carries the human pharmacodynamic dataset — Teichman et al., JCEM 2006.)
Common Questions People Are Asking
What is CJC-1295 (without DAC)?
CJC-1295 without DAC (also called Modified GRF 1-29) is a tetrasubstituted analogue of growth-hormone-releasing hormone, GHRH(1-29). Unlike the DAC version it has no albumin-binding tag, so it is short-acting (~30 min) and drives a physiologic, pulse-like release of growth hormone. Supplied as a lyophilised research-grade powder for laboratory use only.
What does CJC-1295 do?
In research models CJC-1295 binds the pituitary GHRH receptor and stimulates growth-hormone (and downstream IGF-1) release. The no-DAC form produces short, natural-shaped GH pulses; the DAC form sustains the signal for days. These are findings in cell and animal models; New-U supplies it for laboratory research only.
Is CJC-1295 safe?
In published animal studies CJC-1295 has generally been well tolerated, but there are no controlled human safety trials, so human safety is not established. It is a research compound, not a medicine; New-U makes no human-use claims and supplies it for laboratory research only.
What is the difference between CJC-1295 and "Modified GRF 1-29"?
They are the same peptide - a tetrasubstituted GHRH(1-29) without the DAC albumin-binding tag. "Modified GRF 1-29" is the older research name; "CJC-1295 without DAC" became the common marketplace name after the DAC version entered clinical development.
Why is CJC-1295 no DAC usually stacked with ipamorelin?
The two peptides activate different receptors (GHRHR vs GHSR) that synergise in GH release. Combining a GHRH analog with a ghrelin-receptor agonist produces a larger, cleaner GH pulse than either peptide alone - this is the standard research pairing in the literature.
Does the short half-life mean it is worse than the DAC version?
No - just different. The DAC version is for sustained elevation over days; the no-DAC version is for sharp, physiologic pulses. Which one is appropriate depends on the research question, not on which is "stronger".
Is CJC-1295 (no DAC) the same as sermorelin or tesamorelin?
They are related but not identical. All three are GHRH-based peptides that act on the pituitary GHRH receptor. Sermorelin is the unmodified GHRH(1-29) fragment; CJC-1295 no DAC (Modified GRF 1-29) is that same fragment with four stabilising substitutions that resist breakdown and raise GH output; tesamorelin is a separate stabilised GHRH analogue that reached approval for a specific indication. The no-DAC form is studied for its short, pulsatile profile. All are supplied here for laboratory research only.
How should CJC-1295 no DAC be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The four stabilising substitutions make it more robust than native GHRH(1-29), but standard peptide handling still applies.
What happens if you stop taking peptides?
CJC-1295 (no DAC / Modified GRF 1-29) is a short-acting GHRH analogue that prompts the pituitary's own GH pulses. Because its half-life is minutes, the research indicates it clears almost immediately once administration stops, and the GH/IGF-1 axis returns toward its pre-treatment baseline without the suppression seen after exogenous HGH. Effects observed in a study simply lose their stimulus. These are research observations; CJC-1295 no DAC is supplied for laboratory research only and is not for human use.
Where can I buy CJC-1295 (without DAC)?
Right here — CJC-1295 (without DAC) is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging. Strictly for laboratory research use only — not for human use.
How much does CJC-1295 (without DAC) cost?
CJC-1295 (without DAC) pricing is shown live on this page, per pack size — 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $300.
Is CJC-1295 (without DAC) third-party tested?
Yes. Every CJC-1295 (without DAC) batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy CJC-1295 (without DAC)?
Add the CJC-1295 (without DAC) pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). CJC-1295 (without DAC) is supplied strictly for laboratory research use only, not for human or veterinary use.
What payment methods can I use to buy CJC-1295 (without DAC)?
At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.
Is it legal to buy CJC-1295 (without DAC)?
In the United States, CJC-1295 (without DAC) is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction — buyers are responsible for compliance in their own region.
Pharmacokinetics
Research-Observed Effects
Published Research Context
The research literature describes microgram-range subcutaneous amounts, typically 1–3 times daily and often paired with a ghrelin-receptor agonist such as ipamorelin to amplify the GH pulse. These are experimental parameters from research and community settings, recorded as context only.
Stacking Compatibility
Compatible compounds
Avoid combinations
Side Effects (Observed in Literature)
Common
Rare
Dose-dependent
Evidence Tier
Overall: Tier 2: Animal / preclinical
The short-acting no-DAC variant is supported mainly by mechanistic/animal data and the GHRH-analogue class; it has no dedicated human efficacy trials and is not approved. Supplied as unapproved research-grade material.
Tier 1 · Human clinical
Tier 2 · Animal
Source References & Further Reading
Last reviewed: 16 June 2026 · New-U Research Compounds
Key Characteristics
Specifications
About CJC-1295 No DAC (Modified GRF 1-29): Pulsatile GHRH Research Guide
CJC-1295 without DAC - almost always called Modified GRF 1-29 in the older research literature - is one of the most widely used GHRH analogs in peptide research. It takes the minimal functional GHRH sequence (the first 29 residues) and adds four strategic amino-acid substitutions that block the common inactivation pathways without extending the half-life artificially.
The 30-minute half-life is deliberate. Researchers studying the GH axis generally want pulsatile stimulation - a sharp up-and-down signal that mimics what the hypothalamus does naturally - because sustained GHRH exposure desensitises the receptor and flattens the pulse pattern. Mod GRF 1-29 delivers exactly that profile.
New-U Research Compounds supplies CJC-1295 no DAC as a lyophilised, research-grade powder at >99% HPLC purity, verified by independent third-party labs. All material is strictly for in-vitro and preclinical research use. It is not approved for human therapeutic use, and nothing on this page is medical advice.
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