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CJC-1295 (without DAC): HGH / Somatropin research guide
Not medical advice. CJC-1295 (without DAC) is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.
What CJC-1295 (without DAC) is
CJC-1295 without DAC (Modified GRF 1-29) is a short-acting tetrasubstituted GHRH analog that produces clean, physiologic growth hormone pulses without the week-long albumin-bound tail of the DAC version.
One-paragraph overview from our research datasheet — still scientific, but faster to read than the full mechanism list below.
CJC-1295 No DAC (Mod GRF 1-29), tetrasubstituted GHRH(1-29) analogue with DPP-IV resistance for acute pulsatile GH secretion research.
Research contexts
Peer-reviewed literature typically discusses CJC-1295 (without DAC) in specific experimental settings. The points below reflect how the scientific community frames this compound—not as health claims, but as the research questions being asked.
Research vs. personal use: Literature describes experiments in controlled lab and animal models. This is distinct from any real-world use; our products are for laboratory research only.
Typical study contexts
Why HGH / Somatropin research matters
Growth-hormone axis peptides are researched for how they signal through the GH/IGF pathway in animals and cells. Studies focus on endocrine biology and metabolism, not on prescribing or outcomes in people.
Mechanisms (technical review)
Our datasheet lists mechanistic themes observed in preclinical work. These are research endpoints, not health claims. They help scientists understand and compare pathways.
Lab handling & preparation
Storage requirements: Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation. · Learn best practices in our detailed storage guide.
Research dosing context: Literature typically discusses 100–300 mcg subcutaneously · 1–3 times daily, typically pre-sleep and/or pre-training · Functional t½ ≈ 30 min (vs. 6–8 days for DAC version); peak GH response within 15–30 min post-injection; GH pulse duration ~2 h. Often combined with GHSR agonists (e.g., ipamorelin 100–300 mcg) for synergistic pulsatile GH release. No albumin binding, entirely renal/hepatic clearance.
Preparation steps: Follow our detailed reconstitution guide, use the calculator tool for volume confirmation, and always verify purity with the COA reading guide.
Common Questions People Are Asking
What is CJC-1295 (without DAC)?
CJC-1295 without DAC (also called Modified GRF 1-29) is a tetrasubstituted analogue of growth-hormone-releasing hormone, GHRH(1-29). Unlike the DAC version it has no albumin-binding tag, so it is short-acting (~30 min) and drives a physiologic, pulse-like release of growth hormone. Supplied as a lyophilised research-grade powder for laboratory use only.
What does CJC-1295 do?
In research models CJC-1295 binds the pituitary GHRH receptor and stimulates growth-hormone (and downstream IGF-1) release. The no-DAC form produces short, natural-shaped GH pulses; the DAC form sustains the signal for days. These are findings in cell and animal models; New-U supplies it for laboratory research only.
Is CJC-1295 safe?
In published animal studies CJC-1295 has generally been well tolerated, but there are no controlled human safety trials, so human safety is not established. It is a research compound, not a medicine; New-U makes no human-use claims and supplies it for laboratory research only.
What is the difference between CJC-1295 and "Modified GRF 1-29"?
They are the same peptide - a tetrasubstituted GHRH(1-29) without the DAC albumin-binding tag. "Modified GRF 1-29" is the older research name; "CJC-1295 without DAC" became the common marketplace name after the DAC version entered clinical development.
Why is CJC-1295 no DAC usually stacked with ipamorelin?
The two peptides activate different receptors (GHRHR vs GHSR) that synergise in GH release. Combining a GHRH analog with a ghrelin-receptor agonist produces a larger, cleaner GH pulse than either peptide alone - this is the standard research pairing in the literature.
Does the short half-life mean it is worse than the DAC version?
No - just different. The DAC version is for sustained elevation over days; the no-DAC version is for sharp, physiologic pulses. Which one is appropriate depends on the research question, not on which is "stronger".
Is CJC-1295 (no DAC) the same as sermorelin or tesamorelin?
They are related but not identical. All three are GHRH-based peptides that act on the pituitary GHRH receptor. Sermorelin is the unmodified GHRH(1-29) fragment; CJC-1295 no DAC (Modified GRF 1-29) is that same fragment with four stabilising substitutions that resist breakdown and raise GH output; tesamorelin is a separate stabilised GHRH analogue that reached approval for a specific indication. The no-DAC form is studied for its short, pulsatile profile. All are supplied here for laboratory research only.
How should CJC-1295 no DAC be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The four stabilising substitutions make it more robust than native GHRH(1-29), but standard peptide handling still applies.
What happens if you stop taking peptides?
CJC-1295 (no DAC / Modified GRF 1-29) is a short-acting GHRH analogue that prompts the pituitary's own GH pulses. Because its half-life is minutes, the research indicates it clears almost immediately once administration stops, and the GH/IGF-1 axis returns toward its pre-treatment baseline without the suppression seen after exogenous HGH. Effects observed in a study simply lose their stimulus. These are research observations; CJC-1295 no DAC is supplied for laboratory research only and is not for human use.
Is this page medical advice? Can I use CJC-1295 (without DAC) for my health?
No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.
Where do I find CJC-1295 (without DAC) specs, purity certificates and pricing?
Open the shop listing via “View product details.” There you will see batch specs, the Certificate of Analysis (COA), concentration, purity grade, and available SKUs with current pricing.
Related peptide guides
Other compounds researchers often read about alongside CJC-1295 (without DAC).
Scientific sources & further reading
Primary literature and registries for CJC-1295 (without DAC), plus mainstream coverage of the peptide category. Research use only - not medical advice.
Databases & literature:
Peptides in the news:
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Also known as: Modified GRF 1-29, Mod GRF(1-29), CJC-1295 without DAC, Tetrasubstituted GRF(1-29), ModGRF
Premium research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical with a Certificate of Analysis on every lot. Shipped lab-direct, discreet and cold-chain, worldwide. For laboratory research use only.
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