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At 4.90 mg/wk — select pack size

Full sealed case · case-rate pricing · no resupplier markup
Save 31%/mg10 × 10 mg
1 vial lasts
2.0weeks
Pack~5months
$110
$0.77/day$5.39/week
🧬 About this compound

Overview

BPC-157 is a 15-amino-acid pentadecapeptide isolated from human gastric juice that accelerates multi-tissue healing across tendons, ligaments, gut, nerves, and muscle in over 300 preclinical studies.

BPC-157 (Body Protection Compound-157) is a synthetic fragment of a larger protective protein naturally present in the stomach. Its amino acid sequence - GEPPPGKPADDAGLV - is unlike any other known bioactive peptide, and unlike most peptides it stays stable in gastric acid for more than 24 hours.

That stability is one reason BPC-157 has become one of the most widely studied healing peptides in research literature. Animal studies document repair effects across soft tissue injury, gut damage, and peripheral nerve trauma, driven by a small set of well-characterised signalling pathways rather than a single receptor.

For researchers, BPC-157 is a tool compound for studying angiogenesis, cytoprotection, and growth-factor crosstalk. It is not approved for human therapeutic use.

⚙️ How it works

Mechanism of Action

BPC-157 works by switching on several tissue-repair pathways at once - building new blood vessels, recruiting repair cells to the injury site, and protecting cells from further damage.

Pathway Effect Why it matters
VEGFR2 / eNOS / NO Internalises VEGFR2 and sustains nitric oxide release via eNOS activation Drives vasodilation and angiogenesis at the wound bed
FAK-Paxillin Activates focal adhesion kinase and paxillin complexes Accelerates fibroblast and endothelial migration into damaged tissue
Growth Hormone Receptor Upregulates GHR expression in tendon fibroblasts (mRNA + protein) Sensitises connective tissue to repair signals from systemic growth hormone
Egr1 / Nrf2 / NF-κB Upregulates Egr1, Akt1, Nos3; downregulates Nos2 and NF-κB Tilts gene expression toward healing and away from chronic inflammation
Dopamine / Serotonin / GABA Modulates central and peripheral neurotransmitter systems Underlies neuroprotective and mood-related effects in animal CNS models
Deeper dive for scientific readers

Seiwerth et al. (Journal of Physiology and Pharmacology, 2018) showed that BPC-157 drives VEGFR2 internalisation with sustained eNOS activation, while Chang et al. (Molecules, 2014) documented dose- and time-dependent growth-hormone-receptor upregulation in tendon fibroblasts at both the transcript and protein level. Pharmacokinetic work by Xu et al. (Frontiers in Pharmacology, 2022) reports linear kinetics across species, with IM t½ < 30 min and bioavailability of 14-19% in rats and 45-51% in dogs.

❓ FAQ

Common Questions People Are Asking

What is BPC-157?

BPC-157 is a synthetic 15-amino-acid peptide based on a fragment of Body Protection Compound (BPC), a protein naturally found in human gastric juice. Its sequence is GEPPPGKPADDAGLV. It is made in the lab by solid-phase peptide synthesis and supplied as a sterile lyophilised powder for research use only.

What does BPC-157 do?

In preclinical research BPC-157 is studied as a cytoprotective and tissue-repair signalling peptide. Published animal studies report effects on the VEGFR2/eNOS angiogenesis (blood-vessel growth) axis, growth-hormone-receptor upregulation, nitric-oxide signalling, and gastric/gut protection. These are findings in cell and animal models, not demonstrated human effects.

What is BPC-157 used for?

In the research literature BPC-157 is used as a tool compound to study tendon, ligament, muscle, nerve and gastrointestinal tissue repair, gut-lining protection, and angiogenesis. New-U supplies it strictly for in-vitro and animal-model laboratory research; it is not for human use and no therapeutic use is implied.

Does BPC-157 work?

BPC-157 shows consistent, reproducible repair effects across many tissues in hundreds of rodent studies, which is why it is so heavily researched. However, there are no published controlled human clinical trials, so its effectiveness in humans is unproven. It is sold as a research compound only.

How long does BPC-157 take to work?

In animal-model studies, measurable tissue-repair and anti-inflammatory endpoints are typically reported over days to a few weeks of repeated administration, depending on the model, injury type, route and dose. These are research timelines from preclinical studies, not human-use guidance, and study endpoints vary widely.

Is BPC-157 legal?

BPC-157 is not a scheduled or controlled substance in most jurisdictions and can be sold and purchased as a research chemical for laboratory use. It is not an approved medicine, and in 2023 the US FDA placed BPC-157 in a category restricting it from compounding pharmacies. Buyers are responsible for compliance with their local laws. New-U supplies BPC-157 for research use only.

Is BPC-157 FDA approved?

No. BPC-157 is an investigational research peptide and is not approved by the FDA, EMA, or any other major regulator for therapeutic use in humans. It is sold strictly for preclinical and in-vitro research, not for human consumption.

Is BPC-157 banned (WADA)?

Yes. The World Anti-Doping Agency (WADA) prohibits BPC-157 under class S0 (non-approved substances) on the Prohibited List, meaning it is banned both in and out of competition for athletes subject to anti-doping rules. This is one reason it is supplied for laboratory research only.

Is BPC-157 safe?

In published animal studies BPC-157 has been well tolerated with a wide margin and low reported toxicity, but there are no controlled human safety trials, so human safety is not established. It is a research compound, not a medicine; New-U makes no human-use, safety or treatment claims and supplies it for laboratory research only.

Does BPC-157 build muscle?

BPC-157 is not an anabolic or muscle-building agent and is not studied for hypertrophy. The research interest is in repair and recovery of connective tissue (tendon, ligament, muscle fibres) and the gut, via angiogenesis and cytoprotection — not in adding muscle mass. It is supplied for research use only.

How much bacteriostatic water do you mix with BPC-157, and how is it reconstituted?

Lyophilised BPC-157 is dissolved in bacteriostatic water (0.9% benzyl alcohol) for multi-use research vials. Concentration in mg/mL equals the vial mass in mg divided by the millilitres of diluent added — e.g. a 5 mg vial reconstituted with 2 mL gives 2.5 mg/mL, and a 10 mg vial with 2 mL gives 5 mg/mL. New-U does not provide human-use dosing guidance; this is laboratory preparation math only.

Does BPC-157 need to be refrigerated?

Store the lyophilised powder frozen at −20 °C until use. Once reconstituted with bacteriostatic water, keep it refrigerated at 1–6 °C and protected from light; expect roughly 5% degradation per year under those conditions, and avoid repeated freeze-thaw of the reconstituted solution.

What is the molecular formula, molecular weight and half-life of BPC-157?

BPC-157 has the molecular formula C₆₂H₉₈N₁₆O₂₂ and a molecular weight of 1419.53 Da, built from the 15-residue sequence GEPPPGKPADDAGLV. Pharmacokinetic work in rats and dogs reports an intramuscular elimination half-life under 30 minutes with linear kinetics, an IV half-life of roughly 5 minutes, and IM bioavailability of 14-19% (rat) and 45-51% (dog). No formal human pharmacokinetic data has been published.

Why are BPC-157 and TB-500 studied together (the "Wolverine stack")?

BPC-157 and TB-500 are frequently paired in preclinical tissue-repair literature because they act through complementary mechanisms: BPC-157 drives the VEGFR2/eNOS angiogenesis axis and upregulates the growth-hormone receptor, while TB-500 sequesters G-actin and modulates NF-κB-driven inflammation. New-U Research Compounds supplies both as separate research-grade vials for laboratories investigating this combination. Research use only, not a human-use protocol.

Where can I buy research-grade BPC-157, and is a Certificate of Analysis provided?

New-U Research Compounds supplies BPC-157 as a lyophilised research-grade powder in sealed 10-vial packs. Every batch is independently third-party tested by Janoshik Analytics and Freedom Diagnostics to >99% purity by HPLC area normalisation, with identity confirmation by mass spectrometry, and each order ships with its batch-linked Certificate of Analysis. Direct-from-source pricing, discreet worldwide shipping, card and crypto accepted — for laboratory research use only.

What happens if you stop taking peptides?

It depends entirely on the peptide class being studied. For short-half-life research peptides such as BPC-157, the compound clears from the system within hours of the last administration, so it is no longer present to interact with its targets and any tissue-level changes observed in a study simply stop receiving fresh stimulus. BPC-157 is not a hormone-suppressing agent, so the literature does not describe a withdrawal or rebound effect of the kind reported with some hormonal peptides. These are observations from preclinical research models — BPC-157 is supplied for laboratory research only and is not for human use.

How do I buy BPC-157?

Add the BPC-157 pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). BPC-157 is supplied strictly for laboratory research use only, not for human or veterinary use.

What payment methods can I use to buy BPC-157?

At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.

How fast is shipping, and do you ship worldwide?

Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.

⏱️ Pharmacology

Pharmacokinetics

Stability Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation.
Notes IV t½ ~ 5 min; IM t½ < 30 min with linear PK in rats and dogs. IM Tmax ~6-9 min. IM bioavailability 14-19% (rat), 45-51% (dog). Stable in gastric juice >24 hrs. Metabolized via hepatic cytochrome P450; excreted renally and via bile. No human PK data formally published.
📏 Research context

Dosage Ranges (Research Context)

Dose Frequency Duration Notes
200-500 μg per day Once or twice daily, subcutaneous or intramuscular injection IV t½ ~ 5 min; IM t½ < 30 min with linear PK in rats and dogs. IM Tmax ~6-9 min. IM bioavailability 14-19% (rat), 45-51% (dog). Stable in gastric juice >24 hrs. Metabolized via hepatic cytochrome P450; excreted renally and via bile. No human PK data formally published.
📚 Literature

Source References & Further Reading

🧪 What research shows

Research Benefits

Tendon & Ligament Repair

Animal models consistently show faster reconnection of transected Achilles and quadriceps tendons, with measurable strength recovery.

BPC-157 on Wikipedia →

Gastric & Gut Protection

Counteracts NSAID, alcohol, and stress-induced gastric damage; studied in IBD and leaky-gut preclinical models.

Angiogenesis

VEGF-mediated new blood vessel formation delivers oxygen and nutrients to injured tissue, a key prerequisite for repair.

Neuroprotection & Nerve Repair

Supports functional recovery in sciatic nerve transection and traumatic brain injury models via NO- and neurotransmitter-dependent pathways.

Muscle Crush & Strain Recovery

Accelerates histological and functional recovery of skeletal muscle after crush or toxin-induced injury.

Anti-inflammatory Tone

Downregulates NF-κB signalling and pro-inflammatory cytokine release without global immunosuppression.

✅ At a glance

Key Characteristics

  • 15-amino-acid pentadecapeptide (GEPPPGKPADDAGLV)
  • Derived from a protective protein found in human gastric juice
  • Stable in human gastric acid for more than 24 hours
  • Over 300 published preclinical studies across multiple organ systems
  • No known sequence homology to any other bioactive peptide
  • Acts through pathways (VEGFR2, FAK, GHR) rather than a single receptor
  • Research-grade purity: >99% HPLC
  • Independently verified by Janoshik & Freedom Diagnostics
🧪 Technical data

Specifications

Molecular Formula C₆₂H₉₈N₁₆O₂₂
Molecular Weight 1419.53 Da
Sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Purity >99% (HPLC)
Form Lyophilised powder
Half-life (IM) <30 min (rat, dog); linear PK
Bioavailability (IM) 14-19% rat, 45-51% dog
Storage Lyophilised: −20 °C freezer. Reconstituted: 1-6 °C, away from light.
📖 In depth

About BPC-157: Recovery, Gut Health & Tissue Regeneration Research

BPC-157 occupies a unique position in peptide research. It is not a hormone, not a receptor-specific agonist, and not a typical growth factor - it is a short, extremely stable fragment of a larger protective protein first characterised by Sikiric and colleagues in the 1990s. Its signature is breadth: the same molecule improves outcomes in tendon transection, skin wound, gastric ulcer, and peripheral nerve injury models.

Mechanistically, that breadth traces back to a few common denominators. BPC-157 consistently increases local nitric oxide availability, accelerates the migration of fibroblasts and endothelial cells into damaged tissue, and nudges gene expression toward a pro-repair, anti-inflammatory state. It also sensitises connective tissue to the body's own growth-hormone signalling by upregulating the growth hormone receptor.

For researchers, BPC-157 is most useful as a probe for studying how angiogenesis, cytoprotection, and cell migration intersect during tissue repair. It is not approved for human therapeutic use in any major jurisdiction, and human pharmacokinetic data remains limited. All purchases on this site are strictly for in-vitro and preclinical research.