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BPC-157
A gastric-juice-derived pentadecapeptide, BPC-157 is investigated in preclinical models for its role in multi-tissue repair, acting through the VEGFR2-eNOS, FAK-paxillin, and growth-hormone-receptor-upregulation pathways.
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PRECISION. PURITY. PERFORMANCE.
Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.
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Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.
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BPC-157
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Lab-direct quality — full packs or single-vial samples
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a published batch Certificate of Analysis. View the batch Certificate of Analysis → Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a sealed 10-vial research pack , or add a single-vial laboratory sample alongside your pack to evaluate a compound at smaller scale first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
Put simply, researchers study BPC-157 chiefly as a compound involved in recovery and tissue repair — the sections below walk through what that looks like across the literature.
Tendon, ligament & joint recovery
Researchers use animal studies to track how the compound influences tendon, ligament and muscle healing after injury, including how much mechanical strength returns.
Wound & soft-tissue healing
Rodent-model research looks at wound closure timing and the repair of damaged soft tissue.
Gut & digestive-lining support
A substantial base of animal research examines its protective effect on the stomach and intestinal lining, including in the context of NSAID- and alcohol-induced damage.
Nerve repair
Preclinical studies ask whether damaged peripheral nerves regain function with exposure to the compound.
Blood-vessel growth
Investigators examine its part in angiogenesis — new blood vessel formation that supplies the tissue undergoing repair.
Overview
In short: A 15-amino-acid pentadecapeptide isolated from human gastric juice, BPC-157 has been examined across more than 300 preclinical studies for its influence on healing in tendons, ligaments, the gut, nerves, and muscle.
Key research facts
These points summarise lab themes, not human outcomes.
Short for Body Protection Compound-157, BPC-157 is a synthetic fragment cut from a larger protective protein that occurs naturally in the stomach. No other known bioactive peptide shares its amino acid sequence, GEPPPGKPADDAGLV, and unlike most peptides, it holds up in gastric acid for more than 24 hours.
That resilience helps explain why BPC-157 ranks among the most extensively studied healing peptides in the literature. Across soft-tissue injury, gut damage, and peripheral nerve trauma, animal studies record repair effects traceable to a compact set of well-characterised signalling pathways rather than any one receptor.
Within research settings, BPC-157 functions as a tool compound for probing angiogenesis, cytoprotection, and growth-factor crosstalk; it holds no approval for human therapeutic use.
Mechanism of Action
Preclinical models show BPC-157 engaging several tissue-repair pathways simultaneously: it builds new blood vessels, draws repair cells toward the injury site, and shields cells from additional damage.
Seiwerth and colleagues (Journal of Physiology and Pharmacology, 2018) demonstrated VEGFR2 internalisation alongside sustained eNOS activation as a BPC-157 mechanism, and Chang and colleagues (Molecules, 2014) recorded dose- and time-dependent upregulation of the growth hormone receptor in tendon fibroblasts, at both the transcript and protein level. He and colleagues (Frontiers in Pharmacology, 2022) later characterised the pharmacokinetics as linear across species, with an intramuscular t½ under 30 minutes and bioavailability of 14-19% in rats and 45-51% in dogs. The first published first-in-human work (Lee & Burgess, 2025), a two-subject intravenous safety pilot, found BPC-157 well tolerated up to 20 mg with no adverse events reported.
Common Questions People Are Asking
What is BPC-157?
BPC-157 is a synthetic 15-amino-acid peptide based on a fragment of Body Protection Compound (BPC), a protein naturally found in human gastric juice. Its sequence is GEPPPGKPADDAGLV. It is made in the lab by solid-phase peptide synthesis and supplied as a sterile lyophilised powder.
What does BPC-157 do?
In preclinical research BPC-157 is studied as a cytoprotective and tissue-repair signalling peptide. Published animal studies report effects on the VEGFR2/eNOS angiogenesis (blood-vessel growth) axis, growth-hormone-receptor upregulation, nitric-oxide signalling, and gastric/gut protection. These are findings in cell and animal models, not demonstrated human effects.
What is BPC-157 used for?
In the research literature BPC-157 is used as a tool compound to study tendon, ligament, muscle, nerve and gastrointestinal tissue repair, gut-lining protection, and angiogenesis. New-U supplies it strictly for in-vitro and animal-model laboratory research.
Does BPC-157 work?
BPC-157 shows consistent, reproducible repair effects across many tissues in hundreds of rodent studies, which is why it is so heavily researched. However, there are no published controlled human clinical trials, so its effectiveness in humans is unproven. It is sold as a research compound only.
How long does BPC-157 take to work?
In animal-model studies, measurable tissue-repair and anti-inflammatory endpoints are typically reported over days to a few weeks of repeated administration, depending on the model, injury type, route and dose. These are research timelines from preclinical studies, not human-use guidance, and study endpoints vary widely.
Is BPC-157 legal?
BPC-157 is not a scheduled or controlled substance in most jurisdictions and can be sold and purchased as a research chemical for laboratory use. It is not an approved medicine, and in 2023 the US FDA placed BPC-157 in a category restricting it from compounding pharmacies. Buyers are responsible for compliance with their local laws.
Is BPC-157 FDA approved?
No. BPC-157 is an investigational research peptide and is not approved by the FDA, EMA, or any other major regulator for therapeutic use in humans. It is sold strictly for preclinical and in-vitro research.
Is BPC-157 banned (WADA)?
Yes. The World Anti-Doping Agency (WADA) prohibits BPC-157 under class S0 (non-approved substances) on the Prohibited List, meaning it is banned both in and out of competition for athletes subject to anti-doping rules. This is one reason it is supplied for laboratory research only.
Is BPC-157 safe?
In published animal studies BPC-157 has been well tolerated with a wide margin and low reported toxicity, but there are no controlled human safety trials, so human safety is not established.
Does BPC-157 build muscle?
BPC-157 is not an anabolic or muscle-building agent and is not studied for hypertrophy. The research interest is in repair and recovery of connective tissue (tendon, ligament, muscle fibres) and the gut, via angiogenesis and cytoprotection - not in adding muscle mass.
How much bacteriostatic water do you mix with BPC-157, and how is it reconstituted?
Lyophilised BPC-157 is dissolved in bacteriostatic water (0.9% benzyl alcohol) for multi-use research vials. Concentration in mg/mL equals the vial mass in mg divided by the millilitres of diluent added - e.g. a 5 mg vial reconstituted with 2 mL gives 2.5 mg/mL, and a 10 mg vial with 2 mL gives 5 mg/mL. New-U does not provide human-use dosing guidance; this is laboratory preparation math only.
Does BPC-157 need to be refrigerated?
Store the lyophilised powder frozen at −20 °C until use. Once reconstituted with bacteriostatic water, keep it refrigerated at 1–6 °C and protected from light; expect roughly 5% degradation per year under those conditions, and avoid repeated freeze-thaw of the reconstituted solution.
What is the molecular formula, molecular weight and half-life of BPC-157?
BPC-157 has the molecular formula C₆₂H₉₈N₁₆O₂₂ and a molecular weight of 1419.53 Da, built from the 15-residue sequence GEPPPGKPADDAGLV. Pharmacokinetic work in rats and dogs reports an intramuscular elimination half-life under 30 minutes with linear kinetics, an IV half-life of roughly 5 minutes, and IM bioavailability of 14-19% (rat) and 45-51% (dog). No formal human pharmacokinetic data has been published.
Why are BPC-157 and TB-500 studied together (the "Wolverine stack")?
BPC-157 and TB-500 are frequently paired in preclinical tissue-repair literature because they act through complementary mechanisms: BPC-157 drives the VEGFR2/eNOS angiogenesis axis and upregulates the growth-hormone receptor, while TB-500 sequesters G-actin and modulates NF-κB-driven inflammation. New-U Research Compounds supplies both as separate research-grade vials for laboratories investigating this combination.
Where can I buy research-grade BPC-157, and is a Certificate of Analysis provided?
New-U Research Compounds supplies BPC-157 as a lyophilised research-grade powder in sealed 10-vial packs. Every batch is independently third-party tested by Janoshik Analytics and Freedom Diagnostics to >99% purity by HPLC area normalisation, with identity confirmation by mass spectrometry, and each order ships with its batch-linked Certificate of Analysis. Direct-from-source pricing, discreet worldwide shipping, card and crypto accepted.
What happens if you stop taking peptides?
It depends entirely on the peptide class being studied. For short-half-life research peptides such as BPC-157, the compound clears from the system within hours of the last administration, so it is no longer present to interact with its targets and any tissue-level changes observed in a study simply stop receiving fresh stimulus. BPC-157 is not a hormone-suppressing agent, so the literature does not describe a withdrawal or rebound effect of the kind reported with some hormonal peptides. These are observations from preclinical research models.
How much does BPC-157 cost?
BPC-157 pricing is shown live on this page, per pack size - 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $350.
How do I buy BPC-157?
Add the BPC-157 pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step. Every order ships with its batch Certificate of Analysis (COA).
What payment methods can I use to buy BPC-157?
At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes - we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.
Research use only - all claims made on this site are for testing and research use only.
Pharmacokinetics
Research-Observed Effects
Published Research Context
BPC-157 appears across 300+ preclinical tissue-repair studies; reported experimental parameters vary widely by model, species, route and endpoint, and the rodent literature commonly works on a per-kilogram microgram basis. Controlled human dosing has not been established - the only human exposure on record is a two-subject intravenous safety pilot (2025). Any figures in the literature are experimental parameters from controlled research settings.
New-U does not provide human dosing, administration, cycle, or protocol guidance.
Stacking Compatibility
Compatible compounds
Side Effects (Observed in Literature)
Common
Rare
Dose-dependent
Evidence Tier
Overall: Tier 2: Animal / preclinical
Evidence is overwhelmingly preclinical (rodent/canine) with a single two-subject human IV pilot. BPC-157 is not approved by any regulator, is restricted from US compounding pharmacies (FDA 2023), and is WADA-prohibited.
Tier 1 · Human clinical
Tier 2 · Animal
Tier 3 · Anecdotal
Certificates, databases & peer-reviewed sources
Last reviewed: 16 June 2026 · New-U Research Compounds
Key Characteristics
Specifications
About BPC-157: Recovery, Gut Health & Tissue Regeneration Research
BPC-157 holds an unusual place in peptide research: it is neither a hormone nor a receptor-specific agonist nor a conventional growth factor, but a short, highly stable fragment of a larger protective protein, first characterised by Sikiric and colleagues in the 1990s. What sets it apart is breadth — the same molecule shows benefits across tendon transection, skin wound, gastric ulcer, and peripheral nerve injury models.
Mechanistically, that breadth comes down to a handful of shared threads. BPC-157 raises local nitric oxide availability, speeds the migration of fibroblasts and endothelial cells into damaged tissue, and shifts gene expression toward a pro-repair, anti-inflammatory profile — while also sensitising connective tissue to the body's own growth-hormone signalling through growth hormone receptor upregulation.
As a research tool, BPC-157 is most valuable for probing how angiogenesis, cytoprotection, and cell migration intersect during tissue repair. No major jurisdiction has approved it for human therapeutic use, and human pharmacokinetic data remains limited. All purchases on this site are strictly for in-vitro and preclinical research.
Customer Reviews
No drama order
BPC-157 order from New-U was simple. Paid, got tracking, parcel arrived, vial was sealed and the documentation was there. No unneccasary hassle.
- Fatima A******* · 30 August 2026
COA access helped
The BPC-157 COA being available before checkout made the order feel more transparent. The batch detail was easy to match when the product arrived.
- Victor S***** · 30 August 2026
Clear label and batch code
The BPC-157 vial had a clear label and readable batch code. This is basic, but not every supplier gets it right. New-U did a good job here.
- Noah S******** · 30 August 2026
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