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Premium research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical with a Certificate of Analysis on every lot. Shipped lab-direct, discreet and cold-chain, worldwide. For laboratory research use only.
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Research use only (RUO). All products are sold strictly for laboratory and research purposes — not for human or veterinary consumption. Purchasers must be 21 or older.
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AOD-9604
Pick your pack · how long it lasts
At 2.10 mg/wk — select pack size
1 × 10-vial pack required for packing — samples add on to any pack
Lab-direct quality — full packs or single-vial samples
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a batch-linked Certificate of Analysis. View the batch Certificate of Analysis → Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a full sealed 10-vial research pack for a complete study supply, or add a single-vial sample alongside your pack to trial a new compound first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
In plain terms, AOD-9604 is studied mainly as a fat-metabolism compound. Here is what that looks like across the research.
Fat loss & metabolism
Studied for encouraging the breakdown of stored fat while slowing the making of new fat, the part of growth hormone linked to leanness.
Steady blood sugar & metabolism
In clinical research it was investigated for working on fat without disturbing blood sugar or insulin the way full growth hormone can.
Clean lipolysis research tool
Used in studies as a clean probe for fat-cell signalling because it does not raise growth-hormone-linked IGF-1 levels.
Tolerability & safety research
Human trials across roughly 900 participants built an unusually thorough safety record, leading to a GRAS safety designation.
Overview
AOD-9604 is a tyrosine-modified version of the HGH 176-191 fat-loss fragment, originally developed at Monash University and taken through Phase 2b human obesity trials with full GRAS safety designation.
AOD-9604 is the synthetic research descendant of HGH Fragment 176-191. Professor Frank Ng at Monash University showed that replacing the N-terminal phenylalanine with a tyrosine improved stability and lipolytic potency without changing the core mechanism - the fragment still drives fat breakdown through β3-adrenergic receptor upregulation, and it still does not bind the growth hormone receptor or raise IGF-1.
Metabolic Pharmaceuticals took AOD-9604 through a formal clinical trial program spanning six randomised studies and roughly 900 participants. A 12-week Phase 2a trial showed significant weight loss versus placebo, though a larger 24-week Phase 2b missed its primary endpoint at low oral doses. The safety data was strong enough that the molecule received GRAS (Generally Recognized as Safe) designation for food and supplement applications.
AOD-9604 is supplied here as a research-grade lyophilised powder for in-vitro and preclinical study of lipolytic signalling and metabolic pharmacology.
Mechanism of Action
AOD-9604 triggers fat breakdown through the cAMP/PKA pathway and β3-adrenergic receptor upregulation, with no activity at the growth hormone receptor.
Heffernan et al. (Endocrinology, 2001) demonstrated β3-AR dependence: β3-AR knockout mice were completely unresponsive to AOD-9604, nailing down the mechanism. Six clinical trials enrolled roughly 900 participants across Phase 1 and Phase 2 investigations. Serum t½ is ~3-4 min due to rapid N-terminal truncation, but metabolic effects persist beyond plasma clearance. Oral bioavailability is approximately 40% in animal models - unusual for a peptide and a deliberate design goal of the Monash program.
Common Questions People Are Asking
What is AOD-9604?
AOD-9604 is a synthetic, tyrosine-modified version of the C-terminal lipolytic fragment of human growth hormone (Tyr-hGH 177-191) — closely related to native HGH Fragment 176-191, with an added N-terminal tyrosine for stability and lipolytic potency. It was developed to target fat metabolism without the growth or IGF-1 effects of full HGH, and reached Phase 2b human obesity trials. Supplied as a lyophilised research-grade powder for laboratory use only.
What does AOD-9604 do?
In research models AOD-9604 stimulates lipolysis (fat breakdown) and inhibits lipogenesis via a β3-adrenergic-linked mechanism, reportedly without raising IGF-1 or affecting blood glucose the way full HGH does. These are findings in cell and animal models; New-U supplies it for laboratory research only and implies no human effect.
Does AOD-9604 work?
Early and animal research showed lipolytic activity, but the Phase 2b human obesity trial did not produce statistically significant weight loss versus placebo. So its real-world efficacy is unproven, and it is sold as a research compound only — not an approved weight-loss drug.
How is AOD-9604 reconstituted?
For laboratory preparation, dissolve the lyophilised powder in bacteriostatic water: concentration in mg/mL equals the vial mass in mg divided by the millilitres of diluent added. Keep the reconstituted vial refrigerated at 1–6 °C and protected from light. This is preparation math only; New-U provides no human-use dosing guidance.
How is AOD-9604 different from HGH Fragment 176-191?
AOD-9604 is the same lipolytic fragment with a tyrosine substituted for the N-terminal phenylalanine. The tyrosine substitution improves stability and lipolytic potency and was the design choice that enabled the molecule to progress through formal clinical trials as a distinct research entity.
Does AOD-9604 raise IGF-1 or blood sugar?
No - and this was a deliberate design goal. AOD-9604 does not bind the growth hormone receptor, so it does not trigger hepatic IGF-1 synthesis and does not produce the counter-regulatory insulin-opposing effects of full-length HGH. Clinical trials confirmed unchanged glycemic parameters.
Why did the Phase 2b trial fail?
The Phase 2b was an oral-dosing study at 0.25-1 mg/day, and those doses were likely too low to produce meaningful weight loss in humans - the earlier Phase 2a at different dosing had shown ~2.6 kg loss versus 0.8 kg placebo. The failure ended commercial development but did not change the preclinical mechanism data.
How should AOD-9604 be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The disulfide-containing cyclic structure is reasonably stable but plan usage within the normal peptide-handling window.
Where can I buy AOD-9604?
Right here — AOD-9604 is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging. Strictly for laboratory research use only — not for human use.
How much does AOD-9604 cost?
AOD-9604 pricing is shown live on this page, per pack size — 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $300.
Is AOD-9604 third-party tested?
Yes. Every AOD-9604 batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy AOD-9604?
Add the AOD-9604 pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). AOD-9604 is supplied strictly for laboratory research use only, not for human or veterinary use.
What payment methods can I use to buy AOD-9604?
At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.
Is it legal to buy AOD-9604?
In the United States, AOD-9604 is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction — buyers are responsible for compliance in their own region.
Pharmacokinetics
Evidence Tier
Overall: Mixed (human + animal)
AOD-9604 reached human obesity trials (six RCTs, ~900 participants): a 12-week phase 2a reported significant weight loss but the pivotal 24-week phase 2b was endpoint-negative, so human efficacy is unproven. The mechanism is well-supported preclinically, and the molecule holds a GRAS food/supplement designation but NO approved drug indication. Supplied as unapproved laboratory material for research use only.
Tier 1 · Human clinical
Tier 2 · Animal
Source References & Further Reading
Last reviewed: 16 June 2026 · New-U Research Compounds
Key Characteristics
Specifications
About AOD-9604: Lipolytic Growth Hormone Fragment Research Guide
AOD-9604 came out of Monash University's search for a growth hormone derivative that would isolate the fat-burning activity of HGH without the growth, insulin, or IGF-1 effects. The insight was that the last 16 residues of the growth hormone molecule (positions 176-191) carried most of the lipolytic action, and adding a tyrosine at the N-terminus made the fragment more stable and more potent.
Metabolic Pharmaceuticals then ran the kind of clinical trial program that most research peptides never see: six randomised studies across roughly 900 participants, with formal safety, pharmacokinetic, and dose-response data. The Phase 2b trial at low oral doses failed to hit its primary endpoint, which ended commercial development, but the safety package was strong enough that AOD-9604 received GRAS designation for food and supplement use.
New-U Research Compounds supplies AOD-9604 as a research-grade lyophilised powder at >99% HPLC purity, verified by independent third-party labs. All material is strictly for in-vitro and preclinical research. AOD-9604 is not approved as a therapeutic drug, and nothing on this page constitutes medical advice.
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