AOD-9604 is a modified fragment of human growth hormone (amino acids 177-191 + tyrosine). It targets fat metabolism and cartilage repair without raising IGF-1 or affecting blood glucose.

How is AOD-9604 different from HGH Fragment 176-191?

AOD-9604 has an additional tyrosine residue at the N-terminus, improving stability and potentially enhancing activity. It also has more cartilage repair research and holds FDA GRAS status.

Does AOD-9604 affect blood sugar?

No. Unlike full-length GH, AOD-9604 does not activate the GH receptor and has no effect on insulin sensitivity or blood glucose levels.

Can AOD-9604 help with joint issues?

Emerging research shows AOD-9604 stimulates proteoglycan synthesis in cartilage, with promising results in osteoarthritis models. Both systemic and local injection protocols are being studied.

How is AOD-9604 different from HGH Fragment 176-191?

AOD-9604 is the same lipolytic fragment with a tyrosine substituted for the N-terminal phenylalanine. The tyrosine substitution improves stability and lipolytic potency and was the design choice that enabled the molecule to progress through formal clinical trials as a distinct research entity.

Does AOD-9604 raise IGF-1 or blood sugar?

No - and this was a deliberate design goal. AOD-9604 does not bind the growth hormone receptor, so it does not trigger hepatic IGF-1 synthesis and does not produce the counter-regulatory insulin-opposing effects of full-length HGH. Clinical trials confirmed unchanged glycemic parameters.

Why did the Phase 2b trial fail?

The Phase 2b was an oral-dosing study at 0.25-1 mg/day, and those doses were likely too low to produce meaningful weight loss in humans - the earlier Phase 2a at different dosing had shown ~2.6 kg loss versus 0.8 kg placebo. The failure ended commercial development but did not change the preclinical mechanism data.

How should AOD-9604 be stored?

Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The disulfide-containing cyclic structure is reasonably stable but plan usage within the normal peptide-handling window.

Lyophilised · batch-documented · discreet packaging

>99% Purity // Janoshik Verified // GH Fragment // FDA GRAS (food ingredient)

AOD

Name: AOD-9604
Brand: New-U Research Peptides
SKU: aod-9604
Availability: InStock

Modified hGH Fragment 177-191 // CAS 221231-10-3 // Fat Burner + Joint Protector

Fat metabolism without GH side effects. Plus emerging cartilage repair applications.

AOD-9604 is a modified piece of human growth hormone (amino acids 177–191 plus an extra tyrosine). Originally developed as a weight loss drug, it breaks down fat and blocks new fat creation without affecting blood sugar or IGF-1 levels. Recent research also shows promise for cartilage repair, particularly in osteoarthritis. It holds FDA GRAS status as a food ingredient (not as an injectable).

FDA GRAS Generally Recognised As Safe

16 Amino acid modified fragment

Dual Action Fat metabolism + cartilage repair

No IGF-1 Fat loss without GH side effects

Third-party tested

Every batch independently verified by Janoshik & Freedom Diagnostics for purity and identity.

Full COA included

Certificate of Analysis confirms peptide purity, amino acid composition, and absence of contaminants.

Discreet shipping

Every order ships in plain, unmarked packaging with full tracking. No external branding or product details visible.

Research-grade

Uniform vial presentation, consistent labeling, and batch-level documentation every time.

10-vial pack

View Certificate of Analysis COA

Janoshik & Freedom Diagnostics verified
Certificate of analysis per batch
Direct-from-manufacturer sourcing
Discreet, unmarked packaging

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Research use only. All compounds are sold strictly for in-vitro research and educational purposes. Not approved for human use, therapeutic application, or as food or cosmetic products. By purchasing, you agree to use these products only for legitimate research purposes.

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Third-party tested

Full COA included

Discreet shipping

Research-grade

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AOD-9604 Research & Reconstitution Guides

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AOD-9604 Research Guide

AOD-9604 - Plain-English Guide

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