How does KPV reduce inflammation?

KPV works through dual mechanisms: it binds melanocortin receptors (MC1R, MC3R) to activate anti-inflammatory cascades, and it directly inhibits NF-κB nuclear translocation independently of receptor binding.

Can KPV be taken orally?

Yes. Research shows KPV is effective via oral, topical, and systemic routes. Oral capsule formulations have been studied specifically for gut inflammation models.

What is the difference between KPV and α-MSH?

KPV is the minimal active C-terminal tripeptide fragment of α-MSH. It retains the anti-inflammatory activity without the melanogenesis (skin darkening) effects associated with full-length α-MSH or melanotan analogues.

Why does KPV have α-MSH's anti-inflammatory power without its pigmentation effect?

α-MSH produces pigmentation through melanocortin receptor activation at its N-terminal core (around His-Phe-Arg-Trp). KPV is just the C-terminal tail, which has no melanocortin receptor affinity but carries the non-MCR anti-inflammatory activity mediated by NF-κB blockade. Splitting the activities apart is the whole point of using the fragment.

Is KPV primarily a gut peptide?

Not exclusively, but the PepT1 transporter is most abundant in the small intestine and colon, which gives KPV a natural bias toward gut-targeted effects. It has also been studied in cutaneous, ocular, respiratory, and joint inflammation models, so systemic use is valid - gut targeting is just one of its distinctive features.

Can KPV be taken orally?

Its small size and PepT1 uptake give KPV unusually good oral absorption characteristics for a peptide, and oral dosing has been used in preclinical IBD models. That said, formal human oral PK data is limited, so research protocols still use parenteral delivery for consistency.

How should KPV be stored?

Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The tripeptide is one of the smaller and more robust research peptides and tolerates standard handling.

Lyophilised · batch-documented · discreet packaging

>99% Purity // Janoshik Verified // α-MSH Tripeptide // Anti-Inflammatory

KPV

Name: KPV
Brand: New-U Research Peptides
SKU: kpv
Availability: InStock

Lys-Pro-Val // MW 325.41 g/mol // C-Terminal α-MSH Fragment // Immune Modulator

The minimal active anti-inflammatory fragment of alpha-MSH. Potent NF-κB inhibition in just three amino acids.

KPV is a tripeptide (Lys-Pro-Val) derived from the C-terminus of alpha-melanocyte-stimulating hormone (α-MSH). It exerts potent anti-inflammatory effects by binding to melanocortin receptors (MC1R, MC3R) and inhibiting NF-κB signalling independently of its receptor binding. Research demonstrates efficacy in inflammatory bowel disease models, wound healing acceleration, and skin inflammation reduction - effective via oral, topical, and systemic routes.

3 Amino acids

NF-κB Primary target pathway

Multi-Route Oral, topical, systemic

MC1R/MC3R Melanocortin receptors

Third-party tested

Every batch independently verified by Janoshik & Freedom Diagnostics for purity and identity.

Full COA included

Certificate of Analysis confirms peptide purity, amino acid composition, and absence of contaminants.

Discreet shipping

Every order ships in plain, unmarked packaging with full tracking. No external branding or product details visible.

Research-grade

Uniform vial presentation, consistent labeling, and batch-level documentation every time.

10-vial pack

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Certificate of analysis per batch
Direct-from-manufacturer sourcing
Discreet, unmarked packaging

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Research use only. All compounds are sold strictly for in-vitro research and educational purposes. Not approved for human use, therapeutic application, or as food or cosmetic products. By purchasing, you agree to use these products only for legitimate research purposes.

KPV

Third-party tested

Full COA included

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Research-grade

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