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Premium research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical with a Certificate of Analysis on every lot. Shipped lab-direct, discreet and cold-chain, worldwide. For laboratory research use only.
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KPV
Pick your pack · how long it lasts
At 1.75 mg/wk — select pack size
1 × 10-vial pack required for packing — samples add on to any pack
Lab-direct quality — full packs or single-vial samples
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a batch-linked Certificate of Analysis. Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a full sealed 10-vial research pack for a complete study supply, or add a single-vial sample alongside your pack to trial a new compound first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
In plain terms, KPV is studied as a calming, anti-inflammatory peptide, with a strong focus on the gut. Here is what that looks like across the research.
Gut & inflammation
Animal studies look at calming inflamed bowel tissue in colitis and IBD models, where the peptide naturally homes in on the inflamed gut lining.
Immune & inflammatory balance
Research explores how it dials down the body's inflammatory signals without broadly shutting the immune system down.
Skin & irritation research
Preclinical work studies its calming effect on irritated and inflamed skin, such as in dermatitis and allergy models.
Easy-absorbing tiny peptide
Because it is one of the smallest peptides, early research explores how well it absorbs, including by mouth, in gut-targeted models.
Overview
KPV is the three-amino-acid tail of α-melanocyte stimulating hormone that retains the full anti-inflammatory punch of the parent hormone without touching melanocortin receptors.
KPV (lysine-proline-valine) is the C-terminal tripeptide of α-MSH, a 13-residue hormone famous for its anti-inflammatory and pigmentation effects. Researchers discovered that the last three residues alone carry most of the anti-inflammatory activity - through a completely different mechanism than the rest of α-MSH.
While α-MSH produces its anti-inflammatory effect by activating melanocortin receptors, KPV bypasses them entirely. It gets taken up by the PepT1 di/tripeptide transporter (which is heavily expressed in gut epithelium and upregulated during inflammatory bowel disease), translocates to the cell nucleus, and blocks the pro-inflammatory transcription factor NF-κB directly.
That combination of gut-specific uptake and NF-κB targeting makes KPV one of the most interesting research peptides for studying localised intestinal inflammation. Supplied here as sterile lyophilised powder for research use.
Mechanism of Action
KPV slips into cells through the PepT1 transporter, heads straight to the nucleus, and blocks the inflammatory master switch NF-κB - all without activating melanocortin receptors.
Lam et al. (Journal of Biological Chemistry, 2005) showed that KPV translocates into the nucleus and competitively blocks the interaction between importin-α3 and the p65RelA subunit of NF-κB at armadillo domains 7 and 8, stabilising IκBα and preventing nuclear translocation of the inflammatory master regulator. Dalmasso et al. (Gastroenterology, 2008) then demonstrated that PepT1-mediated intestinal uptake - and that PepT1 is upregulated during inflammatory bowel disease - gives KPV a natural targeting mechanism toward inflamed gut tissue.
Common Questions People Are Asking
What is KPV and how does it work?
KPV is the C-terminal tripeptide (Lys-Pro-Val) of α-melanocyte stimulating hormone. It works by entering cells through the PepT1 di/tripeptide transporter, translocating to the nucleus, and competitively blocking the import of the NF-κB p65 subunit — shutting down the master switch for inflammatory gene expression. Crucially it does this without activating melanocortin receptors, so it carries α-MSH's anti-inflammatory activity in isolation.
Why does KPV have α-MSH's anti-inflammatory power without its pigmentation effect?
α-MSH produces pigmentation through melanocortin receptor activation at its N-terminal core (around His-Phe-Arg-Trp). KPV is just the C-terminal tail, which has no melanocortin receptor affinity but carries the non-MCR anti-inflammatory activity mediated by NF-κB blockade. Splitting the activities apart is the whole point of using the fragment.
What does the colitis research actually show?
In the landmark Dalmasso et al. study (Gastroenterology, 2008), oral KPV was transported into colonic cells via PepT1 and reduced both DSS- and TNBS-induced colitis in mice, lowering disease-activity and histological inflammation scores. Mechanistically it inhibited NF-κB and MAP-kinase signalling and reduced pro-inflammatory cytokine secretion in epithelial cells and macrophages. These are preclinical animal-model findings, not demonstrated human effects.
Is KPV primarily a gut peptide?
Not exclusively, but the PepT1 transporter is most abundant in the small intestine and colon, which gives KPV a natural bias toward gut-targeted effects. It has also been studied in cutaneous, ocular, respiratory, and joint inflammation models, so its anti-inflammatory mechanism is broadly relevant — gut targeting is just its most distinctive feature.
Can KPV be taken orally in research models?
Its small size and PepT1 uptake give KPV unusually favourable oral absorption characteristics for a peptide, and oral administration has been used in preclinical IBD models with measurable anti-inflammatory effect. Formal human oral pharmacokinetic data is limited, so published protocols also use parenteral delivery for consistency. KPV is supplied for laboratory research only.
How does KPV compare with BPC-157 for gut research?
Both are studied for gut protection but through different mechanisms. KPV is a direct anti-inflammatory: it blocks NF-κB to dampen the cytokine cascade and homes to inflamed tissue via PepT1. BPC-157 is a broader tissue-repair and cytoprotective peptide acting through VEGFR2/eNOS angiogenesis and growth-hormone-receptor pathways. Researchers studying inflammation specifically often choose KPV; those studying mucosal repair often choose BPC-157.
How should KPV be stored and handled?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1–6 °C and protect from light. The tripeptide is one of the smaller and more robust research peptides and tolerates standard handling, but avoid repeated freeze-thaw cycles of the reconstituted solution.
Where can I buy KPV?
Right here — KPV is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging. Strictly for laboratory research use only — not for human use.
How much does KPV cost?
KPV pricing is shown live on this page, per pack size — 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $300.
Is KPV third-party tested?
Yes. Every KPV batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy KPV?
Add the KPV pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). KPV is supplied strictly for laboratory research use only, not for human or veterinary use.
What payment methods can I use to buy KPV?
At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.
Is it legal to buy KPV?
In the United States, KPV is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction — buyers are responsible for compliance in their own region.
Pharmacokinetics
Evidence Tier
Overall: Tier 2: Animal / preclinical
KPV evidence is preclinical: rodent colitis models plus cell-based NF-κB mechanism work (Lam et al. 2005, Journal of Biological Chemistry — importin-α3 / p65RelA blockade), with no controlled human trials. KPV is NOT approved for human therapeutic use in any jurisdiction; the research-grade material supplied here is unapproved laboratory material.
Tier 2 · Animal
Source References & Further Reading
Last reviewed: 16 June 2026 · New-U Research Compounds
Key Characteristics
Specifications
About KPV (Lys-Pro-Val): α-MSH Tripeptide Anti-Inflammatory Research Guide
KPV (Lys-Pro-Val) is one of the smallest bioactive research peptides you will encounter and one of the cleanest examples of how a fragment can carry a specific activity of its parent protein. α-Melanocyte stimulating hormone does two main things — pigmentation via melanocortin receptors and anti-inflammatory signalling — and the KPV tripeptide isolates the anti-inflammatory arm completely, through a non-melanocortin, NF-κB-targeted mechanism. That selectivity is why KPV is studied as an anti-inflammatory tool compound without the tanning or appetite effects of the full hormone.
For researchers studying inflammatory bowel disease, KPV is unusually elegant. The PepT1 di/tripeptide transporter it uses for uptake is upregulated specifically in inflamed gut epithelium, which means the peptide naturally accumulates where you want it to act. Dalmasso et al. (Gastroenterology, 2008) showed that oral KPV reduces DSS- and TNBS-induced colitis in mice at nanomolar concentrations by blocking NF-κB and MAP-kinase signalling — explaining the strong signal in preclinical colitis models.
New-U Research Compounds supplies KPV as a lyophilised powder at >99% HPLC purity, verified by independent third-party labs. All material is strictly for in-vitro and preclinical research. KPV is not approved for human therapeutic use, and nothing on this page is medical advice.
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