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GHRP-2
Pick your pack · how long it lasts
At 2.10 mg/wk — select pack size
1 × 10-vial pack required for packing — samples add on to any pack
Lab-direct quality — full packs or single-vial samples
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a batch-linked Certificate of Analysis. Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a full sealed 10-vial research pack for a complete study supply, or add a single-vial sample alongside your pack to trial a new compound first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
In plain terms, GHRP-2 is studied mainly as a growth-hormone-release and appetite signalling compound. Here is what that looks like across the research.
Growth hormone & muscle research
Studied for triggering a sharp pulse of the body natural growth hormone, and as a tool in muscle and recovery research that depends on the GH axis.
Appetite & hunger signalling
Research explores how it switches on hunger circuits through the ghrelin receptor, with a moderate appetite effect in study subjects.
Hormone testing & diagnostics
In clinical research it has the rare distinction of an approved diagnostic role in Japan, used to test how well the pituitary releases growth hormone.
Body composition & metabolism
Investigated alongside other GH-axis peptides for its downstream effects on lean mass and fat metabolism.
Overview
GHRP-2 (pralmorelin) is a high-affinity ghrelin receptor agonist and the first growth hormone secretagogue to reach clinical approval as a diagnostic agent for growth hormone deficiency in Japan.
GHRP-2 is a six-amino-acid synthetic peptide that binds the ghrelin receptor GHS-R1a on pituitary cells with high affinity. It is roughly 2-3× more potent than the original GHRP-6 in rat models and was developed specifically to be a better-characterised diagnostic and therapeutic GH secretagogue.
What separates GHRP-2 from other members of the family is its clinical history. It was the first growth hormone secretagogue to receive regulatory approval anywhere in the world - specifically in Japan, as GHRP Kaken 100, a diagnostic agent for confirming growth hormone deficiency. That approval brought formal pharmacokinetic, safety, and dose-response data that most research peptides never get.
GHRP-2 is also unusually versatile in route. It has demonstrated oral and intranasal bioactivity in addition to the usual subcutaneous and IV injection, making it a useful tool for studying ghrelin-receptor pharmacology across delivery modes. Supplied here as sterile lyophilised powder for research use.
Mechanism of Action
GHRP-2 activates the ghrelin receptor on pituitary somatotrophs, triggering a sharp GH pulse with modest increases in cortisol and prolactin.
Bowers et al. (Endocrine Reviews, 1991) first described GHRP-2 as a more potent second-generation GHRP. Hartman et al. (JCEM, 2006) provided the formal clinical diagnostic data: dose-dependent GH responses regardless of age, gender, or obesity status, validating GHRP-2 as a GHD diagnostic stimulus. Japanese regulatory approval came as GHRP Kaken 100 for IV diagnostic use at 100 mcg. Functional SC t½ is roughly 15-30 minutes, with a peak GH response about 15 minutes after dosing.
Common Questions People Are Asking
What is GHRP-2?
GHRP-2 (pralmorelin) is a synthetic six-amino-acid growth hormone secretagogue that binds the ghrelin receptor (GHS-R1a) on the pituitary to trigger a sharp pulse of the body's own growth hormone. It is the first GH secretagogue to gain any regulatory approval, used as a GH-deficiency diagnostic in Japan. Supplied here as a lyophilised research-grade powder for laboratory use only.
What is the difference between GHRP-2 and GHRP-6?
Both are hexapeptide ghrelin-receptor agonists, but GHRP-2 releases more growth hormone per dose while producing a milder appetite (orexigenic) effect. GHRP-6 is the original of the family and the strongest hunger stimulant. Researchers reach for GHRP-2 when they want GH output without the pronounced appetite signal of GHRP-6.
How does GHRP-2 compare with ipamorelin?
GHRP-2 is a stronger GH releaser per dose, but it also produces modest cortisol, ACTH, and prolactin elevation that ipamorelin does not. Ipamorelin is cleaner and more selective; GHRP-2 is more potent and has a richer clinical pharmacokinetic dataset. The choice depends on whether the research protocol prioritises selectivity or potency.
What is the half-life of GHRP-2?
GHRP-2 is short-acting, with a functional half-life on the order of 15-30 minutes. The growth-hormone pulse it triggers typically peaks around 15 minutes after subcutaneous administration and returns toward baseline within roughly an hour, which is why research protocols describe multiple separated doses rather than a single sustained one.
Does GHRP-2 increase appetite?
Moderately. GHRP-2 activates hypothalamic ghrelin receptors enough to produce a noticeable increase in hunger in research subjects, but less dramatically than GHRP-6, which is the strongest orexigenic member of the family. The appetite effect is a direct consequence of acting on the same receptor as natural ghrelin.
Why is GHRP-2 stacked with CJC-1295?
GHRP-2 and CJC-1295 (a GHRH analogue) act on two different receptors - the ghrelin receptor and the GHRH receptor - that converge on growth-hormone release. Combining them in research models produces a larger, cleaner GH pulse than either peptide alone, which is the standard rationale for pairing a GHRP with a GHRH analogue.
Can GHRP-2 be dosed orally?
Oral bioactivity has been demonstrated across multiple species, though absolute oral bioavailability is quite low (roughly 0.3%). That means meaningful oral exposure requires much larger amounts than subcutaneous or IV, but the route does function in research protocols, and intranasal delivery has also been validated.
How should GHRP-2 be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. GHRP-2 is reasonably stable in solution within the standard peptide-handling window.
Where can I buy GHRP-2?
Right here — GHRP-2 is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging. Strictly for laboratory research use only — not for human use.
How much does GHRP-2 cost?
GHRP-2 pricing is shown live on this page, per pack size — 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $300.
Is GHRP-2 third-party tested?
Yes. Every GHRP-2 batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy GHRP-2?
Add the GHRP-2 pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). GHRP-2 is supplied strictly for laboratory research use only, not for human or veterinary use.
What payment methods can I use to buy GHRP-2?
At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.
Is it legal to buy GHRP-2?
In the United States, GHRP-2 is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction — buyers are responsible for compliance in their own region.
Pharmacokinetics
Evidence Tier
Overall: Mixed (human + animal)
GHRP-2 (pralmorelin) is unusual among growth-hormone secretagogues in carrying formal human diagnostic pharmacokinetic/dose-response data and a Japanese regulatory approval as a GH-deficiency diagnostic agent. It is NOT FDA-approved and has no approved therapeutic indication; the research-grade material supplied here is unapproved laboratory material.
Tier 1 · Human clinical
Tier 2 · Animal
Source References & Further Reading
Last reviewed: 16 June 2026 · New-U Research Compounds
Key Characteristics
Specifications
About GHRP-2 (Pralmorelin): Growth Hormone Secretagogue Research Guide
GHRP-2, known generically as pralmorelin, is the most clinically characterised of the second-generation growth hormone releasing peptides. It is a synthetic hexapeptide and high-affinity agonist of the ghrelin receptor (GHS-R1a) on pituitary somatotrophs, and its approval in Japan in 2004 as a diagnostic agent for confirming growth hormone deficiency (GHRP Kaken 100) brought it through the kind of formal pharmacokinetic and dose-response work that most research peptides never receive.
In comparative studies with GHRP-6 (the original member of the family) and hexarelin (the most potent version), GHRP-2 sits in the middle. It is a stronger GH releaser per dose than GHRP-6 but produces a more modest appetite signal, and it generates less cortisol and prolactin elevation than hexarelin. That combination of good potency with tolerable secondary effects is why it became the GHRP of choice for diagnostic work and the standard partner for GHRH analogues like CJC-1295 in research stacks, where the two receptor pathways converge for supra-additive GH release.
New-U Research Compounds supplies GHRP-2 as a research-grade lyophilised powder at >99% HPLC purity, verified by independent third-party labs. All material is strictly for in-vitro and preclinical laboratory research. GHRP-2 is not approved for general human therapeutic use outside of its specific Japanese diagnostic indication, and nothing on this page constitutes medical advice.
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