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    CJC-1295 (with DAC)

    Pick your pack · how long it lasts

    At 2.00 mg/wk — select pack size

    1 × 10-vial pack required for packing — samples add on to any pack

    Lab-direct quality — full packs or single-vial samples

    Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a batch-linked Certificate of Analysis. View the batch Certificate of Analysis → Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.

    Order a full sealed 10-vial research pack for a complete study supply, or add a single-vial sample alongside your pack to trial a new compound first. Same lab, same batch, same verified purity — scaled to whatever your research needs.

    What It's Researched For

    In plain terms, CJC-1295 with DAC is the long-acting version studied for steady, week-long growth-hormone support from a single dose. Here is what that looks like across the research.

    Long-acting GH support

    Human research explores how one dose keeps growth hormone raised for about a week, so studies do not need daily injections.

    Muscle & lean mass

    Studied for the sustained rise in growth hormone and IGF-1 that supports lean body mass and protein building.

    Fat & body composition

    Research examines shifts in body composition that follow steady, longer-term growth-hormone elevation.

    Sustained IGF-1

    Early human studies look at how IGF-1, the main downstream messenger of growth hormone, stays elevated for many days after a single dose.

    Paired research

    Often studied with ipamorelin, where one compound works the growth-hormone switch and the other works a second switch for a larger combined effect.

    Overview

    CJC-1295 with DAC is a long-acting GHRH analog that covalently bonds to serum albumin, extending its functional half-life from minutes to roughly 6-8 days for weekly GH research protocols.

    CJC-1295 DAC is GHRH(1-29) with two things stacked on top. First, it is tetrasubstituted (D-Ala2, Gln8, Ala15, Leu27) to resist the DPP-IV enzyme that would otherwise chew it up. Second, it carries a small chemistry tag called a Drug Affinity Complex (DAC) that covalently snaps onto the free cysteine (Cys34) of serum albumin within minutes of injection.

    That second modification is the big deal. Once the peptide is piggy-backing on albumin, it is shielded from both enzymatic degradation and kidney filtration. Functional half-life jumps from about 7 minutes (native GHRH) to roughly 6-8 days - about a 700-fold extension.

    The practical research consequence is that a single subcutaneous injection keeps GH elevated 2-10x above baseline for roughly a week, with IGF-1 elevation persisting even longer. That makes CJC-1295 DAC the go-to tool for studies that want prolonged GH axis activation without daily dosing.

    Mechanism of Action

    CJC-1295 DAC hijacks serum albumin as a carrier, letting a GHRH analog stay in circulation for a week and continuously nudge the pituitary to release growth hormone.

    Pathway Effect Why it matters GHRH receptor Full agonist at the pituitary somatotroph GHRHR Triggers cAMP-dependent GH exocytosis like native GHRH DAC / albumin conjugation Covalent bond to serum albumin Cys34 within ~15 min Shields the peptide from degradation and renal clearance for days Tetrasubstitution D-Ala2, Gln8, Ala15, Leu27 block proteases Stops DPP-IV and common oxidation pathways from inactivating the peptide Pulsatile GH release Drives 2-10× GH elevation for 6+ days per dose Provides prolonged GHRH axis activation from a single injection IGF-1 accumulation IGF-1 elevation persists 9-28 days with repeat dosing Produces a steady anabolic downstream signal Deeper dive for scientific readers

    Jette et al. (Endocrinology, 2005) characterised the maleimidopropionic acid (MPA) DAC chemistry and demonstrated the ~700-fold half-life extension via covalent albumin binding. Teichman et al. (JCEM, 2006) then reported the human PD study in 66 healthy adults: a single SC injection produced dose-dependent 2-10× plasma GH elevation lasting 6+ days, with 1.5-3× IGF-1 increases persisting 9-11 days after one dose and accumulating over 28 days with repeated dosing.

    Common Questions People Are Asking

    What is CJC-1295?

    CJC-1295 is a synthetic analogue of growth-hormone-releasing hormone (GHRH 1-29) with four amino-acid substitutions that resist enzymatic breakdown. It activates the pituitary GHRH receptor to drive growth-hormone release. This DAC version adds a "Drug Affinity Complex" tag that binds serum albumin, extending its half-life to ~6-8 days. Supplied as a lyophilised research-grade powder for laboratory use only.

    What does CJC-1295 do?

    In research models CJC-1295 binds the GHRH receptor on the pituitary and stimulates the release of growth hormone, which in turn raises IGF-1. The DAC tag sustains that signal for days rather than minutes. These are findings in cell and animal models; no human therapeutic effect is implied.

    Is CJC-1295 safe?

    In published animal studies CJC-1295 has generally been well tolerated, but there are no controlled human safety trials, so human safety is not established. It is a research compound, not a medicine; New-U makes no human-use claims and supplies it for laboratory research only.

    Is CJC-1295 FDA approved?

    No. CJC-1295 is an investigational research peptide and is not approved by the FDA, EMA, or any other regulator for human therapeutic use. It is sold strictly for preclinical and in-vitro research.

    What does "DAC" actually mean?

    DAC stands for "Drug Affinity Complex". It is a small chemistry tag - specifically maleimidopropionic acid - attached to the C-terminal lysine of the peptide. When you inject the peptide, the DAC reacts with the free thiol of cysteine-34 on serum albumin, forming a covalent bond. The peptide then piggy-backs on albumin for days.

    How is CJC-1295 DAC different from the no-DAC version?

    Both share the same tetrasubstituted GHRH(1-29) backbone. The DAC version carries the albumin-binding tag and lasts ~6-8 days; the no-DAC version (often called Modified GRF 1-29) has no DAC tag and lasts roughly 30 minutes. DAC is used for sustained elevation; no-DAC is used for physiologic pulses.

    Which is better - CJC-1295 DAC or no-DAC?

    Neither is universally "better" - they answer different research questions. The DAC form gives sustained, days-long GH/IGF-1 elevation from a single dose and is studied on roughly weekly schedules thanks to its 6-8 day half-life. The no-DAC form (Modified GRF 1-29) produces short, natural-shaped GH pulses and is studied with more frequent dosing. The choice depends on whether a study needs continuous elevation or pulsatile signalling. Both are research-use-only materials, not approved medicines.

    Why combine CJC-1295 with ipamorelin?

    GHRH analogs like CJC-1295 and ghrelin-receptor agonists like ipamorelin hit two different receptors (GHRHR and GHSR) that synergise in GH release. Combining them produces larger, cleaner GH pulses than either peptide alone, which is why this is a standard research pairing.

    How should CJC-1295 DAC be stored?

    Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The DAC chemistry is relatively stable once the peptide is in solution, but plan dosing to use reconstituted material within the standard peptide-stability window.

    What happens if you stop taking peptides?

    CJC-1295 is a GHRH analogue that stimulates the pituitary's own GH release rather than replacing a hormone. In the research literature, ending administration returns the GH/IGF-1 axis toward its untreated baseline; the DAC form's albumin binding means it clears over a week or more, so the stimulus tapers gradually rather than stopping instantly. Unlike exogenous HGH, no axis-shutdown rebound is described. These are research-model observations — CJC-1295 DAC is supplied for laboratory research only and is not for human use.

    Where can I buy CJC-1295 (with DAC)?

    Right here — CJC-1295 (with DAC) is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging. Strictly for laboratory research use only — not for human use.

    How much does CJC-1295 (with DAC) cost?

    CJC-1295 (with DAC) pricing is shown live on this page, per pack size — 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $300.

    Is CJC-1295 (with DAC) third-party tested?

    Yes. Every CJC-1295 (with DAC) batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.

    How do I buy CJC-1295 (with DAC)?

    Add the CJC-1295 (with DAC) pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). CJC-1295 (with DAC) is supplied strictly for laboratory research use only, not for human or veterinary use.

    What payment methods can I use to buy CJC-1295 (with DAC)?

    At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.

    How fast is shipping, and do you ship worldwide?

    Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.

    Is it legal to buy CJC-1295 (with DAC)?

    In the United States, CJC-1295 (with DAC) is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction — buyers are responsible for compliance in their own region.

    Pharmacokinetics

    Half-life Terminal t½ 5.8–8.1 days; covalent albumin (Cys34) binding occurs within ~15 min of injection Absorption route Subcutaneous injection; the Drug Affinity Complex conjugates to serum albumin in circulation Bioavailability Sustained systemic exposure via covalent albumin binding (shielded from proteolysis and renal filtration) Metabolism / clearance Gradual proteolytic degradation of the albumin-bound peptide; no CYP-mediated interactions Stability Lyophilised: −20 °C. Reconstituted: 1–6 °C, protect from light Notes GH elevation persists ≥6 days per dose; IGF-1 elevation 9–11 days after a single dose, reaching steady state over ~28 days with repeated dosing (Teichman 2006).

    Research-Observed Effects

  • Single subcutaneous dose produced dose-dependent 2–10× plasma GH elevation for ≥6 days in healthy adults (Teichman 2006)
  • IGF-1 elevated 1.5–3× baseline, persisting 9–11 days after a single dose and accumulating to steady state by ~28 days
  • Approximately 700-fold functional half-life extension versus native GHRH
  • Preserves GHRH-receptor-mediated, somatostatin-regulated pulsatility
  • Reached Phase II clinical trials for lipodystrophy and growth-hormone deficiency before development was discontinued

    • Published Research Context

    The human pharmacodynamic study (Teichman 2006) administered single and repeated subcutaneous doses to characterise GH/IGF-1 kinetics; the long albumin-bound half-life is why once-weekly schedules are described in the research literature. These are experimental parameters from controlled and community research settings, recorded as context only.

    Stacking Compatibility

    Compatible compounds

  • Ipamorelin: GHRH-receptor (CJC-1295) + ghrelin-receptor (ipamorelin) co-activation produces supra-additive GH release — the standard research pairing
  • GHRP-2: Alternative ghrelin-receptor agonist partner for amplifying the GH pulse

    • Avoid combinations

  • CJC-1295 no-DAC / Sermorelin / Tesamorelin (other GHRH analogues): Redundant GHRH-receptor occupancy — no additive research rationale
  • Exogenous recombinant GH: Direct GH dosing suppresses the endogenous axis the GHRH analogue is meant to stimulate

    • Side Effects (Observed in Literature)

    Common

  • Injection-site reactions (redness, itching, swelling)
  • Transient flushing or warmth after injection

    • Rare

  • Headache or dizziness
  • Fluid retention / peripheral oedema and transient reduced insulin sensitivity with sustained GH/IGF-1 elevation
  • Numbness or tingling

    • Dose-dependent

  • GH/IGF-1-related effects (fluid retention, glucose changes) scale with the degree and duration of elevation

    • Evidence Tier

    Overall: Mixed (human + animal)

    Human pharmacodynamic and early-phase clinical data exist for the reference compound, but CJC-1295 DAC was never approved. The research-grade material supplied here is unapproved laboratory material.

    Tier 1 · Human clinical

  • Teichman et al. JCEM 2006 — pharmacodynamic/PK study in 66 healthy adults
  • Phase II clinical trials for lipodystrophy and growth-hormone deficiency (development later discontinued)

    • Tier 2 · Animal

  • Jette et al. Endocrinology 2005 — DAC/albumin-binding chemistry and ~700× half-life extension

    • Source References & Further Reading

    Last reviewed: 16 June 2026 · New-U Research Compounds

  • Teichman SL et al. Prolonged Stimulation of GH and IGF-I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults. J Clin Endocrinol Metab. · 2006 · PMID: 16352683 · DOI: 10.1210/jc.2005-1536
  • Jette L et al. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats (DAC chemistry). Endocrinology. · 2005
  • PubMed: peer-reviewed literature on CJC-1295
  • ClinicalTrials.gov: registered studies on CJC-1295
  • CJC-1295: Wikipedia
  • WebMD: consumer health reference
  • BBC News: Health
  • CNN Health: “Peptides: what to know about the wellness trend”
  • Sky News: “Can peptides make America healthy again?”
  • Sky News: “Inside the exploding US peptides craze” (video)
  • Sky News Australia: “Black market peptide trade explodes as influencers fuel uptick in use”
  • Sky News Australia: “Backyard peptide boom sparks alarm” (video)
  • Sky News Australia: “Oprah reveals struggle with shame of weight-loss drugs”

    • Key Characteristics

  • GHRH(1-29) tetrasubstituted backbone
  • Covalent DAC chemistry binds albumin Cys34 after injection
  • Functional half-life ~6-8 days (vs minutes for native GHRH)
  • Typical research dose 1-2 mg once or twice weekly
  • Produces 2-10× GH elevation for ~6 days per dose
  • IGF-1 stays elevated 9-28 days with repeat dosing
  • Preserves somatostatin-regulated pulsatility
  • Research-grade purity: >99% HPLC

    • Specifications

    Molecular Formula Modified GHRH(1-29) with MPA DAC tag Molecular Weight 3647.3 Da Backbone GHRH(1-29) with D-Ala2, Gln8, Ala15, Leu27 substitutions Purity >99% (HPLC) Form Lyophilised powder Half-life 5.8-8.1 days Route Subcutaneous injection, weekly Albumin binding Covalent via maleimidopropionic acid to Cys34 Storage Lyophilised: −20 °C freezer. Reconstituted: 1-6 °C, away from light.

    About CJC-1295 DAC: Long-Acting GHRH Analog Research Guide

    CJC-1295 with DAC came out of ConjuChem's work on covalent drug-affinity complex chemistry, which aimed to give short-lived peptides a ride on serum albumin for days instead of minutes. The original therapeutic target was HIV-associated lipodystrophy and growth hormone deficiency, and the molecule actually reached Phase II clinical trials before development stalled - not for safety reasons, but because the commercial landscape shifted toward other GH secretagogues.

    For researchers, CJC-1295 DAC is the long-acting reference point in the GHRH analog family. It is the tool you reach for when you want sustained GH/IGF-1 elevation from a single injection and when daily dosing is not practical. Its close sibling, CJC-1295 without DAC (modified GRF 1-29), is the short-acting counterpart that produces physiologic pulses instead.

    New-U Research Compounds supplies CJC-1295 DAC as a research-grade lyophilised powder at >99% HPLC purity, verified by independent third-party labs. All material is strictly for in-vitro and preclinical research. It is not approved for human therapeutic use, and nothing on this page constitutes medical advice.

  • CJC-1295 - Wikipedia
  • Growth hormone-releasing hormone - Wikipedia
  • Human serum albumin - Wikipedia
  • Growth hormone - Wikipedia

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    • CJC-1295 (with DAC) vs related HGH / Somatropin compounds

    Compound Price Purity spec COA CJC-1295 (with DAC) from $59 >99% HPLC 1 published batch Tesamorelin from $47 >99% HPLC On request Sermorelin from $43 >99% HPLC On request
  • CJC-1295 (with DAC) vs Tesamorelin — full comparison
  • CJC-1295 (with DAC) vs Sermorelin — full comparison

    • Descriptive catalog comparison for research sourcing decisions — not dosing guidance. All compounds are for laboratory research use only.

    More on CJC-1295 (with DAC)

  • CJC-1295 (with DAC) research guide
  • Buy CJC-1295 (with DAC) — pricing & packs

    • Research use only — not for human consumption. All products are supplied strictly for laboratory research purposes.

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