Sermorelin is bioidentical to the first 29 amino acids of human GHRH. It stimulates the pituitary to produce GH within the body’s natural regulatory system.

How is Sermorelin different from CJC-1295?

Sermorelin is bioidentical and clears quickly for natural GH pulses. CJC-1295 has a DAC modification extending half-life to days for sustained stimulation.

Why does Sermorelin have more safety data?

It was used in FDA-approved paediatric treatments (as Geref), creating a clinical safety baseline most research peptides lack.

Can Sermorelin be stacked with Ipamorelin?

Yes. Sermorelin + Ipamorelin is a classic combination: GHRH initiation + selective GHRP amplification without cortisol elevation.

How is sermorelin different from exogenous HGH?

HGH is the finished hormone and directly activates the GH receptor on every tissue. Sermorelin works one step upstream - it tells the pituitary to secrete its own GH in a physiologic pulse, preserving somatostatin feedback. That generally produces a more natural release pattern but a lower peak than direct HGH dosing.

Why is sermorelin usually dosed at bedtime?

The body naturally releases most of its GH during early deep sleep via a hypothalamic GHRH pulse. Evening dosing of sermorelin aligns the induced pulse with this natural rhythm, amplifying the physiologic nocturnal surge rather than creating a new one at an unusual time.

Can sermorelin be combined with ipamorelin or another GHRP?

Yes - combining a GHRH analog with a ghrelin-receptor agonist is a common research pairing. The two mechanisms are complementary (GHRHR plus GHSR), and the combined GH release is larger than either peptide alone in published studies.

How should sermorelin be stored?

Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. Sermorelin is relatively stable once reconstituted but should be used within the standard peptide-stability window.

What does sermorelin do?

Sermorelin is a synthetic 29-amino-acid fragment of growth-hormone-releasing hormone (GHRH 1-29). In research models it binds the GHRH receptor on the anterior pituitary and prompts the gland to synthesise and release the body's own growth hormone in a natural pulse, rather than supplying growth hormone directly. New-U supplies sermorelin strictly for laboratory research use only.

What are the researched benefits of sermorelin?

In the clinical and preclinical literature, sermorelin-induced GH release has been studied for downstream effects on the GH/IGF-1 axis - body composition, sleep architecture, recovery markers and IGF-1 elevation - while preserving the pituitary's own somatostatin feedback. These are research findings; sermorelin is not sold for human use and New-U makes no therapeutic claims.

What sermorelin dosage is described in the research literature?

Published research and the historical clinical record (sermorelin was once marketed as Geref) describe microgram-to-low-milligram subcutaneous amounts once daily, typically at night to match the natural nocturnal GH pulse. New-U publishes this only as descriptive research context - it is not a dosing instruction, and sermorelin is supplied strictly for laboratory research, not human use.

What side effects are reported with sermorelin in studies?

The research and historical clinical literature most commonly note injection-site reactions (redness, swelling), occasional flushing, headache or transient dizziness; serious effects are uncommon at the amounts studied because the pituitary's own feedback caps GH output. This is summarised research context, not medical advice - sermorelin is a research compound, not an approved medicine.

How do sermorelin and ipamorelin differ?

Sermorelin is a GHRH analogue (it acts on the GHRH receptor); ipamorelin is a selective ghrelin-receptor (GHSR) agonist. They drive growth-hormone release through two different receptors, which is why they are frequently co-studied as a complementary pair. See our Ipamorelin vs Sermorelin research comparison for the full mechanism-by-mechanism breakdown.

How quickly are sermorelin effects observed in research (before vs after)?

IGF-1 and GH-pulse changes are measurable within days to weeks in study settings, while body-composition and sleep endpoints are typically assessed over 8-24 weeks of continued research dosing. Timelines depend entirely on the protocol and endpoint measured. Reported for research context only - not a human-use claim.

Lyophilised · batch-documented · discreet packaging

>99% Purity // Janoshik Verified // Bioidentical GHRH // 29 Amino Acids

Sermorelin

Name: Sermorelin
Brand: New-U Research Peptides
SKU: sermorelin
Availability: InStock

Bioidentical GHRH(1-29)NH2 // CAS 86168-78-7 // Natural GH Stimulator

The body’s own GHRH sequence. The most physiologically natural approach to GH axis support.

Sermorelin is chemically identical to the first 29 amino acids of your body’s own Growth Hormone Releasing Hormone (GHRH). Unlike CJC-1295 with its extended-life modification, Sermorelin mirrors your natural GHRH pattern - clearing quickly and producing frequent, short GH pulses that match your body’s daily rhythm. It was used in FDA-approved paediatric growth hormone treatments.

Bioidentical To natural GHRH(1-29)

FDA History Approved paediatric use

29 Amino acids

3–6 Months Typical cycle length

Third-party tested

Every batch independently verified by Janoshik & Freedom Diagnostics for purity and identity.

Full COA included

Certificate of Analysis confirms peptide purity, amino acid composition, and absence of contaminants.

Discreet shipping

Every order ships in plain, unmarked packaging with full tracking. No external branding or product details visible.

Research-grade

Uniform vial presentation, consistent labeling, and batch-level documentation every time.

10-vial pack

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Certificate of analysis per batch
Direct-from-manufacturer sourcing
Discreet, unmarked packaging

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Research use only. All compounds are sold strictly for in-vitro research and educational purposes. Not approved for human use, therapeutic application, or as food or cosmetic products. By purchasing, you agree to use these products only for legitimate research purposes.

Sermorelin

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Full COA included

Discreet shipping

Research-grade

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