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Sermorelin
Pick your pack · how long it lasts
At 1.40 mg/wk — select pack size
1 × 10-vial pack required for packing — samples add on to any pack
Lab-direct quality — full packs or single-vial samples
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a batch-linked Certificate of Analysis. Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a full sealed 10-vial research pack for a complete study supply, or add a single-vial sample alongside your pack to trial a new compound first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
In plain terms, sermorelin is studied for prompting the body to release its own growth hormone in natural pulses. Here is what that looks like across the research.
Sleep & nightly GH pulse
Studied for nudging the natural overnight growth-hormone surge, which is why research dosing is timed to bedtime.
Muscle & lean mass
Research explores how the gentle rise in growth hormone and IGF-1 supports lean body mass and recovery over time.
Fat & body composition
Investigated for shifts in body composition that follow a more natural, pulse-like growth-hormone signal.
Healthy ageing
As a former approved diagnostic with extensive human data, studied for the age-related drop in growth hormone and the IGF-1 axis.
Paired research
Often studied alongside ipamorelin, where the two work through different switches for a larger combined growth-hormone pulse.
Overview
Sermorelin is the synthetic 29-amino-acid N-terminal fragment of GHRH and the shortest peptide that still acts as a full growth hormone releasing hormone receptor agonist.
Sermorelin is a trimmed-down version of the body's own GHRH. The natural hormone is 44 amino acids long, but as early as the 1980s researchers showed the first 29 residues retained essentially all the receptor-activating activity. That discovery made sermorelin the pharmacological baseline for every GHRH analog that followed.
Unlike injecting growth hormone directly, sermorelin tells the pituitary to release its own GH in natural pulses. The hypothalamic somatostatin brake is still active, so the pituitary never gets stuck in the "on" position - a key reason researchers use GHRH analogs when they want to study physiologic GH dynamics rather than brute-force elevation.
Sermorelin was FDA-approved as Geref in 1997 for pediatric growth hormone deficiency, then voluntarily withdrawn in 2008 for commercial rather than safety reasons. It remains a well-characterised research tool for studying the GHRH axis. Supplied here as sterile lyophilised powder for research use.
Mechanism of Action
Sermorelin binds the GHRH receptor on pituitary somatotrophs and triggers a pulse of natural growth hormone, preserving the body's own feedback control.
Ling et al. (Biochemical and Biophysical Research Communications, 1984) originally showed that the N-terminal 29 residues of GHRH(1-44) were sufficient for full receptor activation. Prakash and Goa (BioDrugs, 1999) characterised the pharmacokinetics in detail: Tmax 5-20 min SC, t½ 11-12 min, absolute SC bioavailability ~6%, clearance 2.4-2.8 L/min, Vd 23.7-25.8 L. The short half-life is intentional - it is what produces pulsatile, physiologic GH release rather than sustained stimulation.
Common Questions People Are Asking
What is sermorelin?
Sermorelin is a synthetic 29-amino-acid peptide corresponding to the active fragment of growth-hormone-releasing hormone (GHRH 1-29). It signals the pituitary to release its own growth hormone. It is supplied as a lyophilised research-grade powder for laboratory use only.
What does sermorelin do?
In research models sermorelin binds the pituitary GHRH receptor and prompts a natural, pulse-like release of growth hormone (and downstream IGF-1), rather than supplying GH directly. These are findings in research models; New-U supplies it for laboratory research only and implies no human therapeutic effect.
Does sermorelin work?
Sermorelin is a well-characterised GHRH analogue and reliably stimulates pituitary GH release in published studies, which is why it is so widely researched. Effectiveness for any human outcome is a separate, medically-supervised question outside our scope — it is sold strictly as a research compound.
What is sermorelin used for?
In the research literature sermorelin is used as a tool compound to study the GH/IGF-1 axis, pituitary function and body-composition endpoints, often paired with a ghrelin-receptor agonist such as ipamorelin. New-U supplies it strictly for in-vitro and animal-model research; it is not for human use.
Is sermorelin safe?
Sermorelin has a long research and (historically) clinical record as a GHRH analogue, but research-grade material is not an approved sterile medicine and carries no human safety assurances. New-U supplies it for laboratory research only and makes no human-use or safety claims.
Is sermorelin FDA approved?
Sermorelin was historically FDA-approved (as Geref) but that branded product was discontinued; it is no longer marketed as an approved drug, though it remains available through compounding pharmacies by prescription. New-U's sermorelin is research-grade material supplied for laboratory research only — not an approved medicine and not for human use.
How is sermorelin different from exogenous HGH?
HGH is the finished hormone and directly activates the GH receptor on every tissue. Sermorelin works one step upstream - it tells the pituitary to secrete its own GH in a physiologic pulse, preserving somatostatin feedback. That generally produces a more natural release pattern but a lower peak than direct HGH dosing.
Why is sermorelin usually dosed at bedtime?
The body naturally releases most of its GH during early deep sleep via a hypothalamic GHRH pulse. Evening dosing of sermorelin aligns the induced pulse with this natural rhythm, amplifying the physiologic nocturnal surge rather than creating a new one at an unusual time.
Can sermorelin be combined with ipamorelin or another GHRP?
Yes - combining a GHRH analog with a ghrelin-receptor agonist is a common research pairing. The two mechanisms are complementary (GHRHR plus GHSR), and the combined GH release is larger than either peptide alone in published studies.
How should sermorelin be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. Sermorelin is relatively stable once reconstituted but should be used within the standard peptide-stability window.
What are the researched benefits of sermorelin?
In the clinical and preclinical literature, sermorelin-induced GH release has been studied for downstream effects on the GH/IGF-1 axis - body composition, sleep architecture, recovery markers and IGF-1 elevation - while preserving the pituitary's own somatostatin feedback. These are research findings; sermorelin is not sold for human use and New-U makes no therapeutic claims.
What sermorelin dosage is described in the research literature?
Published research and the historical clinical record (sermorelin was once marketed as Geref) describe microgram-to-low-milligram subcutaneous amounts once daily, typically at night to match the natural nocturnal GH pulse. New-U publishes this only as descriptive research context - it is not a dosing instruction, and sermorelin is supplied strictly for laboratory research, not human use.
What side effects are reported with sermorelin in studies?
The research and historical clinical literature most commonly note injection-site reactions (redness, swelling), occasional flushing, headache or transient dizziness; serious effects are uncommon at the amounts studied because the pituitary's own feedback caps GH output. This is summarised research context, not medical advice - sermorelin is a research compound, not an approved medicine.
How do sermorelin and ipamorelin differ?
Sermorelin is a GHRH analogue (it acts on the GHRH receptor); ipamorelin is a selective ghrelin-receptor (GHSR) agonist. They drive growth-hormone release through two different receptors, which is why they are frequently co-studied as a complementary pair. See our Ipamorelin vs Sermorelin research comparison for the full mechanism-by-mechanism breakdown.
How quickly are sermorelin effects observed in research (before vs after)?
IGF-1 and GH-pulse changes are measurable within days to weeks in study settings, while body-composition and sleep endpoints are typically assessed over 8-24 weeks of continued research dosing. Timelines depend entirely on the protocol and endpoint measured. Reported for research context only - not a human-use claim.
What happens if you stop taking peptides?
Sermorelin and other GHRH-analogue research peptides act by prompting the pituitary to release its own growth hormone rather than supplying hormone directly, so the published literature describes the GH/IGF-1 axis returning toward its pre-treatment baseline once stimulation ends — without the shutdown associated with stopping exogenous HGH. Any effects seen in a study fade as the short-acting peptide clears. These are research observations; sermorelin is supplied for laboratory research only and is not for human use.
Where can I buy Sermorelin?
Right here — Sermorelin is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging. Strictly for laboratory research use only — not for human use.
How much does Sermorelin cost?
Sermorelin pricing is shown live on this page, per pack size — 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $300.
Is Sermorelin third-party tested?
Yes. Every Sermorelin batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy Sermorelin?
Add the Sermorelin pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). Sermorelin is supplied strictly for laboratory research use only, not for human or veterinary use.
What payment methods can I use to buy Sermorelin?
At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.
Is it legal to buy Sermorelin?
In the United States, Sermorelin is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction — buyers are responsible for compliance in their own region.
Pharmacokinetics
Evidence Tier
Overall: Mixed (human + animal)
Sermorelin (GHRH 1-29) carries an unusually complete evidence base for a research peptide: the minimal-active-fragment pharmacology was established mechanistically (Ling et al., 1984) and it later became an FDA-approved drug (Geref) with substantial human clinical/PK data. That approval lapsed in 2008 for commercial reasons, so the compound is now research-only — the material supplied here is unapproved laboratory material, not the former finished drug.
Tier 1 · Human clinical
Source References & Further Reading
Last reviewed: 16 June 2026 · New-U Research Compounds
Key Characteristics
Specifications
About Sermorelin (GHRH 1-29): Pulsatile Growth Hormone Research Guide
Sermorelin (GHRH 1-29) is the original GHRH analogue. Everything that came after it - tesamorelin, the CJC-1295 family, MOD-GRF - builds on the observation that a 29-residue truncation of the natural hormone retains all the receptor-activating pharmacology. That insight made sermorelin the reference molecule for any research protocol that wants to generate physiologic growth-hormone pulses rather than override them with exogenous hormone, and it is why sermorelin is still studied head-to-head with ipamorelin and the CJC-1295 family.
The clinical backstory is worth knowing. Sermorelin was FDA-approved in 1997 as Geref for pediatric growth hormone deficiency diagnosis and treatment. It was voluntarily discontinued in 2008, not for any safety or efficacy problem, but because the market had moved toward recombinant HGH and the economics no longer worked. The clinical safety and pharmacokinetic data set accumulated during that era is still one of the most complete for any GHRH analog.
New-U Research Compounds supplies sermorelin as a sterile lyophilised powder at >99% HPLC purity, verified by independent third-party labs. It is a research tool for studying the GHRH/GH axis and is not a licensed medicine. Nothing on this page constitutes medical advice.
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