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  • Sermorelin

    • Sermorelin

    Sermorelin (GHRH 1-29), truncated growth hormone-releasing hormone fragment retaining full GHRHR agonist activity for pulsatile GH research.

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    Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.

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    Sermorelin

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    Lab-direct quality — full packs or single-vial samples

    Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity . Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.

    Order a sealed 10-vial research pack , or add a single-vial laboratory sample alongside your pack to evaluate a compound at smaller scale first. Same lab, same batch, same verified purity — scaled to whatever your research needs.

    What It's Researched For

    In plain terms, sermorelin is studied for prompting the body to release its own growth hormone in natural pulses. Here is what that looks like across the research.

    Sleep & nightly GH pulse

    Studied for nudging the natural overnight growth-hormone surge, which is why research dosing is timed to bedtime.

    Muscle & lean mass

    Research explores how the gentle rise in growth hormone and IGF-1 supports lean body mass and recovery over time.

    Fat & body composition

    Investigated for shifts in body composition that follow a more natural, pulse-like growth-hormone signal.

    Healthy ageing

    As a former approved diagnostic with extensive human data, studied for the age-related drop in growth hormone and the IGF-1 axis.

    Paired research

    Often studied alongside ipamorelin, where the two work through different switches for a larger combined growth-hormone pulse.

    Overview

    In short: Sermorelin is the synthetic 29-amino-acid N-terminal fragment of GHRH and the shortest peptide that still acts as a full growth hormone releasing hormone receptor agonist.

    Key research facts

  • Full GHRHR agonist activity in a minimal 29-amino acid peptide fragment for growth hormone research
  • Preserves endogenous GH pulsatility and hypothalamic-pituitary axis integrity via somatostatin feedback
  • Stimulates pituitary GH gene transcription maintaining long-term somatotroph function
  • Avoids tachyphylaxis associated with continuous exogenous GH administration
  • Former FDA-approved diagnostic and therapeutic agent for pediatric growth hormone deficiency

    • These points summarise lab themes, not human outcomes.

    Sermorelin is a trimmed-down version of the body's own GHRH. The natural hormone is 44 amino acids long, but as early as the 1980s researchers showed the first 29 residues retained essentially all the receptor-activating activity. That discovery made sermorelin the pharmacological baseline for every GHRH analog that followed.

    Unlike injecting growth hormone directly, sermorelin tells the pituitary to release its own GH in natural pulses. The hypothalamic somatostatin brake is still active, so the pituitary never gets stuck in the "on" position - a key reason researchers use GHRH analogs when they want to study physiologic GH dynamics rather than brute-force elevation.

    Sermorelin was FDA-approved as Geref in 1997 for pediatric growth hormone deficiency, then voluntarily withdrawn in 2008 for commercial rather than safety reasons. It remains a well-characterised research tool for studying the GHRH axis. Supplied here as sterile lyophilised powder for research use.

    Mechanism of Action

    Sermorelin binds the GHRH receptor on pituitary somatotrophs and triggers a pulse of natural growth hormone, preserving the body's own feedback control.

    Pathway Effect Why it matters GHRH receptor Full agonist at the pituitary somatotroph GHRHR Triggers cAMP-dependent GH exocytosis cAMP / PKA Activates adenylyl cyclase inside somatotrophs The canonical second messenger that releases stored GH GH gene transcription Drives pituitary GH gene expression over time Preserves long-term somatotroph function rather than depleting stores Somatostatin feedback Leaves the natural off-switch intact Maintains pulsatility and avoids tachyphylaxis GHRP synergy Combines with ghrelin-receptor agonists for additive GH release Common research pairing with ipamorelin, GHRP-2, or GHRP-6 Deeper dive for scientific readers

    Ling et al. (Biochemical and Biophysical Research Communications, 1984) originally showed that the N-terminal 29 residues of GHRH(1-44) were sufficient for full receptor activation. Prakash and Goa (BioDrugs, 1999) characterised the pharmacokinetics in detail: Tmax 5-20 min SC, t½ 11-12 min, absolute SC bioavailability ~6%, clearance 2.4-2.8 L/min, Vd 23.7-25.8 L. The short half-life is intentional - it is what produces pulsatile, physiologic GH release rather than sustained stimulation.

    Common Questions People Are Asking

    What is sermorelin?

    Sermorelin is a synthetic 29-amino-acid peptide corresponding to the active fragment of growth-hormone-releasing hormone (GHRH 1-29). It signals the pituitary to release its own growth hormone. It is supplied as a lyophilised research-grade powder for laboratory use only.

    What does sermorelin do?

    In research models sermorelin binds the pituitary GHRH receptor and prompts a natural, pulse-like release of growth hormone (and downstream IGF-1), rather than supplying GH directly. These are findings in research models; New-U supplies it for laboratory research only and implies no human therapeutic effect.

    Does sermorelin work?

    Sermorelin is a well-characterised GHRH analogue and reliably stimulates pituitary GH release in published studies, which is why it is so widely researched. Effectiveness for any human outcome is a separate, medically-supervised question outside our scope - it is sold strictly as a research compound.

    What is sermorelin used for?

    In the research literature sermorelin is used as a tool compound to study the GH/IGF-1 axis, pituitary function and body-composition endpoints, often paired with a ghrelin-receptor agonist such as ipamorelin. New-U supplies it strictly for in-vitro and animal-model research.

    Is sermorelin safe?

    Sermorelin has a long research and (historically) clinical record as a GHRH analogue, but research-grade material is not an approved sterile medicine and carries no human safety assurances. New-U supplies it for laboratory research only and makes no human-use or safety claims.

    Is sermorelin FDA approved?

    Sermorelin was historically FDA-approved (as Geref) but that branded product was discontinued; it is no longer marketed as an approved drug, though it remains available through compounding pharmacies by prescription. New-U's sermorelin is research-grade material supplied for laboratory research only - not an approved medicine.

    How is sermorelin different from exogenous HGH?

    HGH is the finished hormone and directly activates the GH receptor on every tissue. Sermorelin works one step upstream - it tells the pituitary to secrete its own GH in a physiologic pulse, preserving somatostatin feedback. That generally produces a more natural release pattern but a lower peak than direct HGH dosing.

    Why is sermorelin usually dosed at bedtime?

    The body naturally releases most of its GH during early deep sleep via a hypothalamic GHRH pulse. Evening dosing of sermorelin aligns the induced pulse with this natural rhythm, amplifying the physiologic nocturnal surge rather than creating a new one at an unusual time.

    Can sermorelin be combined with ipamorelin or another GHRP?

    Yes - combining a GHRH analog with a ghrelin-receptor agonist is a common research pairing. The two mechanisms are complementary (GHRHR plus GHSR), and the combined GH release is larger than either peptide alone in published studies.

    How should sermorelin be stored?

    Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. Sermorelin is relatively stable once reconstituted but should be used within the standard peptide-stability window.

    What are the researched benefits of sermorelin?

    In the clinical and preclinical literature, sermorelin-induced GH release has been studied for downstream effects on the GH/IGF-1 axis - body composition, sleep architecture, recovery markers and IGF-1 elevation - while preserving the pituitary's own somatostatin feedback. These are research findings; sermorelin is not sold for human use and New-U makes no therapeutic claims.

    What sermorelin dosage is described in the research literature?

    Published research and the historical clinical record (sermorelin was once marketed as Geref) describe microgram-to-low-milligram subcutaneous amounts once daily, typically at night to match the natural nocturnal GH pulse. New-U publishes this only as descriptive research context - it is not a dosing instruction, and sermorelin is supplied strictly for laboratory research, not human use.

    What side effects are reported with sermorelin in studies?

    The research and historical clinical literature most commonly note injection-site reactions (redness, swelling), occasional flushing, headache or transient dizziness; serious effects are uncommon at the amounts studied because the pituitary's own feedback caps GH output. This is summarised research context, not medical advice - sermorelin is a research compound, not an approved medicine.

    How do sermorelin and ipamorelin differ?

    Sermorelin is a GHRH analogue (it acts on the GHRH receptor); ipamorelin is a selective ghrelin-receptor (GHSR) agonist. They drive growth-hormone release through two different receptors, which is why they are frequently co-studied as a complementary pair. See our Ipamorelin vs Sermorelin research comparison for the full mechanism-by-mechanism breakdown.

    How quickly are sermorelin effects observed in research (before vs after)?

    IGF-1 and GH-pulse changes are measurable within days to weeks in study settings, while body-composition and sleep endpoints are typically assessed over 8-24 weeks of continued research dosing. Timelines depend entirely on the protocol and endpoint measured. Reported for research context only - not a human-use claim.

    What happens if you stop taking peptides?

    Sermorelin and other GHRH-analogue research peptides act by prompting the pituitary to release its own growth hormone rather than supplying hormone directly, so the published literature describes the GH/IGF-1 axis returning toward its pre-treatment baseline once stimulation ends - without the shutdown associated with stopping exogenous HGH. Any effects seen in a study fade as the short-acting peptide clears. These are research observations.

    Where can I buy Sermorelin?

    Right here - Sermorelin is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.

    How much does Sermorelin cost?

    Sermorelin pricing is shown live on this page, per pack size - 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $350.

    Is Sermorelin third-party tested?

    Yes. Every Sermorelin batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.

    How do I buy Sermorelin?

    Add the Sermorelin pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step. Every order ships with its batch Certificate of Analysis (COA).

    What payment methods can I use to buy Sermorelin?

    At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.

    How fast is shipping, and do you ship worldwide?

    Yes - we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.

    Is it legal to buy Sermorelin?

    In the United States, Sermorelin is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction - buyers are responsible for compliance in their own region.

    Research use only - all claims made on this site are for testing and research use only.

    Pharmacokinetics

    Stability Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation. Notes IV/SC t½ ≈ 11–12 min; Tmax = 5–20 min (SC); absolute bioavailability ~6% (SC); clearance 2.4–2.8 L/min; Vd = 23.7–25.8 L; GH elevation persists ~3 h despite rapid peptide clearance. Intranasal bioavailability only 3–5%.

    Evidence Tier

    Overall: Mixed (human + animal)

    Sermorelin (GHRH 1-29) carries an unusually complete evidence base for a research peptide: the minimal-active-fragment pharmacology was established mechanistically (Ling et al., 1984) and it later became an FDA-approved drug (Geref) with substantial human clinical/PK data. That approval lapsed in 2008 for commercial reasons, so the compound is now research-only - the material supplied here is unapproved laboratory material, not the former finished drug.

    Tier 1 · Human clinical

  • Formerly FDA-approved as Geref (1997) for paediatric growth-hormone-deficiency diagnosis and treatment; voluntarily withdrawn from the US market in 2008 for commercial, not safety, reasons
  • Prakash & Goa (BioDrugs, 1999; PMID 18031173) - human pharmacokinetic and clinical review drawing on the trial dataset accumulated during its approved-drug era

    • Certificates, databases & peer-reviewed sources

    Last reviewed: 16 June 2026 · New-U Research Compounds

  • Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. · 1999 · PMID: 18031173 · DOI: 10.2165/00063030-199912020-00007
  • PubMed: peer-reviewed literature on Sermorelin
  • ClinicalTrials.gov: registered studies on Sermorelin
  • Sermorelin: Wikipedia
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    • Key Characteristics

  • 29-amino-acid N-terminal fragment of native GHRH
  • Shortest fully active GHRH receptor agonist
  • Preserves natural somatostatin feedback loop
  • Former FDA-approved drug (Geref), well-characterised PK
  • Short half-life (~12 min) drives physiologic pulses
  • Typically dosed subcutaneously at bedtime
  • Commonly stacked with ipamorelin or GHRP-2 in research
  • Research-grade purity: >99% HPLC

    • Specifications

    Molecular Formula C 149 H 246 N 44 O 42 S Molecular Weight 3357.9 Da Sequence GHRH residues 1-29, C-terminal amide Purity >99% (HPLC) Form Lyophilised powder Half-life ~11-12 min (IV/SC) Bioavailability (SC) ~6% Route Subcutaneous injection, typically evening Storage Lyophilised: −20 °C freezer. Reconstituted: 1-6 °C, away from light.

    About Sermorelin (GHRH 1-29): Pulsatile Growth Hormone Research Guide

    Sermorelin (GHRH 1-29) is the original GHRH analogue. Everything that came after it - tesamorelin, the CJC-1295 family, MOD-GRF - builds on the observation that a 29-residue truncation of the natural hormone retains all the receptor-activating pharmacology. That insight made sermorelin the reference molecule for any research protocol that wants to generate physiologic growth-hormone pulses rather than override them with exogenous hormone, and it is why sermorelin is still studied head-to-head with ipamorelin and the CJC-1295 family.

    The clinical backstory is worth knowing. Sermorelin was FDA-approved in 1997 as Geref for pediatric growth hormone deficiency diagnosis and treatment. It was voluntarily discontinued in 2008, not for any safety or efficacy problem, but because the market had moved toward recombinant HGH and the economics no longer worked. The clinical safety and pharmacokinetic data set accumulated during that era is still one of the most complete for any GHRH analog.

    New-U Research Compounds supplies sermorelin as a sterile lyophilised powder at >99% HPLC purity, verified by independent third-party labs. It is a research tool for studying the GHRH/GH axis and is not a licensed medicine. Nothing on this page constitutes medical advice.

  • Sermorelin - Wikipedia
  • Growth hormone-releasing hormone - Wikipedia
  • Growth hormone - Wikipedia
  • Somatotropic cell - Wikipedia

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    • Descriptive catalog comparison for research sourcing decisions - not dosing guidance.

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    • Part of the Growth hormone secretagogue research research area — explore related compounds, guides and sources.

    Research use only — not for human consumption. All products are supplied strictly for laboratory research purposes.

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