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GHRP-6
Pick your pack · how long it lasts
At 2.10 mg/wk — select pack size
1 × 10-vial pack required for packing — samples add on to any pack
Lab-direct quality — full packs or single-vial samples
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a batch-linked Certificate of Analysis. Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a full sealed 10-vial research pack for a complete study supply, or add a single-vial sample alongside your pack to trial a new compound first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
In plain terms, GHRP-6 is studied mainly as an appetite and growth-hormone-release compound. Here is what that looks like across the research.
Appetite & hunger signalling
Research explores its strong hunger signal, the most pronounced of its peptide family, through the ghrelin receptor in the brain.
Growth hormone & muscle research
Studied for prompting the body own growth hormone release, and used as a research tool in GH-axis muscle and recovery work.
Heart-tissue protection
Animal studies look at whether it shields heart tissue from damage after reduced blood flow.
Body composition & metabolism
Investigated for its downstream effects on lean mass and fat metabolism through the growth-hormone pathway.
Overview
GHRP-6 is the original growth hormone releasing peptide - the hexapeptide whose discovery in the 1980s first revealed that the ghrelin receptor was a separate, GH-releasing pathway from GHRH.
GHRP-6 is the foundational member of the GHRP class. Cyril Bowers and colleagues at Tulane University synthesised it in the 1980s while exploring modifications of enkephalin-like peptides, and stumbled onto something unexpected: this little six-residue peptide released GH through a completely different receptor than GHRH. That observation kicked off the field that eventually led to the discovery of the ghrelin receptor and ghrelin itself.
Of all the GHRPs, GHRP-6 has the strongest appetite-stimulating profile - it binds hypothalamic ghrelin receptors hard enough to drive a noticeable increase in hunger within 15-20 minutes. That makes it a useful research tool for studying appetite regulation and orexigenic signalling in models where you want the hunger response as a readout.
Like hexarelin, GHRP-6 also activates CD36 scavenger receptors, giving it cardioprotective properties in preclinical myocardial infarction models. Supplied here as sterile lyophilised powder for research use.
Mechanism of Action
GHRP-6 activates two receptors simultaneously - the ghrelin receptor GHS-R1a for GH release and appetite, and CD36 for cytoprotective signalling in heart tissue.
Bowers et al. (Endocrine Reviews, 1991) first characterised GHRP-6 and proposed the existence of a GH-releasing receptor distinct from the GHRH receptor - a prediction later confirmed by the cloning of GHSR and the discovery of its natural ligand, ghrelin. Cabrales et al. (European Journal of Pharmaceutical Sciences, 2013) reported biexponential PK with distribution t½ 7.6 min and elimination t½ 2.5 h after IV bolus in healthy volunteers. Oral bioavailability is low (~0.3%). Berlanga-Acosta et al. (2006) documented a 78% reduction in myocardial necrosis in porcine infarction models - the CD36 signal in action.
Common Questions People Are Asking
What is GHRP-6?
GHRP-6 is the original growth hormone releasing peptide - a synthetic six-amino-acid peptide that binds the ghrelin receptor (GHS-R1a) on the pituitary to trigger a pulse of the body's own growth hormone. It also acts on the CD36 scavenger receptor and is the strongest appetite stimulant of the GHRP family. Supplied as a lyophilised research-grade powder for laboratory use only.
Why does GHRP-6 cause hunger?
GHRP-6 is an agonist at the ghrelin receptor GHS-R1a, which is found not only on pituitary somatotrophs (where it releases GH) but also on hypothalamic NPY/AgRP neurons in the arcuate nucleus that regulate appetite. Activating those hypothalamic receptors mimics what natural ghrelin does after a period of fasting - it signals hunger.
What is the difference between GHRP-6 and GHRP-2?
Both are hexapeptide ghrelin-receptor agonists. GHRP-6 is the original and the most orexigenic, with a strong hunger signal; GHRP-2 releases more growth hormone per dose with a milder appetite effect. Researchers choose GHRP-6 when the appetite response is wanted and GHRP-2 when GH output without strong hunger is the goal.
How does GHRP-6 compare with hexarelin and ipamorelin?
All are ghrelin-receptor agonists. GHRP-6 is the original and most orexigenic; hexarelin is the most potent GH releaser and has the clearest CD36 cardiac profile; ipamorelin is the cleanest and most selective, with minimal cortisol, prolactin, or appetite effect. GHRP-6 sits at the "strong hunger, dual receptor" end of the spectrum.
What is the half-life of GHRP-6?
A human pharmacokinetic study reported a biexponential disposition: a short distribution half-life of about 7.6 minutes and an elimination half-life of roughly 2.5 hours after intravenous dosing. The functional growth-hormone effect after subcutaneous injection is short, with the GH peak occurring within about 15-30 minutes.
Can GHRP-6 be combined with GHRH analogs?
Yes - this is a standard research stack. GHRP-6 plus a GHRH analogue such as sermorelin or CJC-1295 produces supra-additive GH release because the two peptides activate different receptors (the ghrelin receptor and the GHRH receptor) that converge on GH exocytosis.
What is the CD36 cardioprotective effect?
Beyond the pituitary, GHRP-6 binds the CD36 scavenger receptor on heart muscle cells. In preclinical infarction models this activation has been associated with reduced myocardial damage and improved post-infarct remodelling, an effect that is independent of growth-hormone release. These are animal-model findings reported for research context only.
How should GHRP-6 be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. GHRP-6 is fairly stable in solution within the normal peptide-handling window.
Where can I buy GHRP-6?
Right here — GHRP-6 is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging. Strictly for laboratory research use only — not for human use.
How much does GHRP-6 cost?
GHRP-6 pricing is shown live on this page, per pack size — 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $300.
Is GHRP-6 third-party tested?
Yes. Every GHRP-6 batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy GHRP-6?
Add the GHRP-6 pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). GHRP-6 is supplied strictly for laboratory research use only, not for human or veterinary use.
What payment methods can I use to buy GHRP-6?
At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.
Is it legal to buy GHRP-6?
In the United States, GHRP-6 is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction — buyers are responsible for compliance in their own region.
Pharmacokinetics
Evidence Tier
Overall: Tier 2: Animal / preclinical
GHRP-6 has a small human pharmacokinetic pilot, but its GH-release and cardioprotective findings are predominantly preclinical (rodent/porcine). It has no approved indication and is not approved by any regulator for human therapeutic use; the material supplied here is unapproved research material.
Tier 1 · Human clinical
Tier 2 · Animal
Source References & Further Reading
Last reviewed: 16 June 2026 · New-U Research Compounds
Key Characteristics
Specifications
About GHRP-6: Original Growth Hormone Releasing Peptide Research Guide
GHRP-6 has a special place in endocrinology history. It is the prototypical growth hormone releasing peptide - a synthetic hexapeptide (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) developed by the American endocrinologist Cyril Y. Bowers in the 1980s. Before his lab synthesised it, everyone assumed growth-hormone release was controlled by a single pathway: GHRH from the hypothalamus acting on the GHRH receptor. GHRP-6 broke that model by releasing GH without touching GHRHR at all, and that observation led directly to the cloning of the ghrelin receptor (GHS-R1a) and the subsequent discovery of ghrelin itself as the natural ligand.
Practically, GHRP-6 is the GHRP researchers reach for when both arms of ghrelin-receptor signalling matter - growth-hormone release and the strongest appetite stimulation in the family - and when the cardioprotective CD36 effect is also relevant. Its pronounced hunger signal makes it less suitable for weight-loss-focused metabolic research, but it is an ideal tool compound for orexigenic-signalling studies, and it remains a common partner for GHRH analogues such as CJC-1295 in supra-additive GH-release stacks. Formal human pharmacokinetics describe a biexponential profile with a distribution half-life around 7.6 minutes and an elimination half-life of about 2.5 hours.
New-U Research Compounds supplies GHRP-6 as a research-grade lyophilised powder at >99% HPLC purity, verified by independent third-party labs. All material is strictly for in-vitro and preclinical laboratory research. GHRP-6 is not approved for human therapeutic use, and nothing on this page constitutes medical advice.
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