Shop by goal
Popular compounds
Research resources
Recently viewed
Hexarelin: HGH / Somatropin research guide
Not medical advice. Hexarelin is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.
What Hexarelin is
Hexarelin is a potent six-amino-acid growth hormone secretagogue that uniquely activates both the ghrelin receptor (for GH release) and CD36 scavenger receptors on cardiomyocytes (for cardioprotective signalling).
One-paragraph overview from our research datasheet — still scientific, but faster to read than the full mechanism list below.
Hexarelin (Examorelin), potent hexapeptide GHS-R1a agonist producing synergistic GH release with GHRH and cardioprotective CD36 receptor activation.
Research contexts
Peer-reviewed literature typically discusses Hexarelin in specific experimental settings. The points below reflect how the scientific community frames this compound—not as health claims, but as the research questions being asked.
Research vs. personal use: Literature describes experiments in controlled lab and animal models. This is distinct from any real-world use; our products are for laboratory research only.
Typical study contexts
Why HGH / Somatropin research matters
Growth-hormone axis peptides are researched for how they signal through the GH/IGF pathway in animals and cells. Studies focus on endocrine biology and metabolism, not on prescribing or outcomes in people.
Mechanisms (technical review)
Our datasheet lists mechanistic themes observed in preclinical work. These are research endpoints, not health claims. They help scientists understand and compare pathways.
Lab handling & preparation
Storage requirements: Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation. · Learn best practices in our detailed storage guide.
Research dosing context: Literature typically discusses 100–200 mcg subcutaneously · 1–3 times daily · GH Tmax ≈ 30 min; GH returns to baseline within 240 min with t½ ≈ 55 min; SC t½ ≈ 1–2 h; detectable up to 8 h post-administration. GH plateau at 140 mU/L at 1.0 mcg/kg dose. Partial reversible tolerance develops with chronic use (50–75% efficacy reduction over weeks–months).
Preparation steps: Follow our detailed reconstitution guide, use the calculator tool for volume confirmation, and always verify purity with the COA reading guide.
Common Questions People Are Asking
How is hexarelin different from GHRP-6?
Hexarelin is a more potent version of the GHRP-6 scaffold with two non-natural amino-acid substitutions (D-2-methyltryptophan and D-phenylalanine) that improve stability and GH-releasing potency. It also has clearer CD36-mediated cardiac effects than the simpler GHRP-6.
What is the CD36 mechanism doing in cardiac tissue?
CD36 is a scavenger receptor that handles fatty acid uptake and calcium channel modulation in cardiomyocytes. Hexarelin activation of cardiac CD36 improves calcium handling and has been proposed as a mechanism for its cardioprotective effects in post-ischemic injury models.
Does hexarelin cause cortisol elevation?
Yes, hexarelin produces some cortisol and prolactin elevation at higher doses, more than ipamorelin but generally less than GHRP-6. Low-dose protocols minimise those secondary effects while preserving GH release.
How should hexarelin be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The non-natural amino acid substitutions give it better shelf stability than simpler GHRPs.
Hexarelin vs ipamorelin - how do they compare?
Both are ghrelin-receptor (GHSR) agonists that release growth hormone, but hexarelin is the more potent GH releaser and adds CD36-mediated cardiac activity, while ipamorelin is the cleaner, more selective option with minimal cortisol, prolactin or appetite effect. Hexarelin also desensitises faster with continuous exposure. See our Hexarelin vs Ipamorelin research comparison for the full mechanism breakdown.
Hexarelin vs GHRP-2 - what is the difference?
Both are hexapeptide ghrelin-receptor agonists, but hexarelin is the more potent GH releaser per dose and uniquely adds CD36-mediated cardiac activity, while GHRP-2 produces a more modest GH pulse with a milder cortisol and prolactin profile. Hexarelin also desensitises (loses effect) faster with sustained exposure, which is why research protocols built around it favour lower amounts and cycling. Both are supplied strictly for laboratory research, not human use.
What hexarelin dosage is used in research?
Research protocols describe low-microgram subcutaneous amounts, often split through the day, with lower amounts used to limit cortisol/prolactin rise and receptor desensitisation. New-U publishes this as descriptive research context only - it is not a dosing instruction, and hexarelin is supplied strictly for laboratory research, not human use.
What is hexarelin studied for?
Beyond growth-hormone release, hexarelin is studied for CD36-mediated cardioprotective effects in post-ischaemic injury models and for calcium-handling in cardiomyocytes - an angle the simpler GHRPs lack. These are preclinical research findings; New-U makes no therapeutic claims and sells hexarelin for research use only.
Does hexarelin lose effect over time (desensitisation)?
Yes - continuous high-amount exposure downregulates the ghrelin receptor and blunts the GH response faster than with ipamorelin, which is why research protocols favour lower amounts and cycling. Reported for research context only, not a human-use protocol.
Is this page medical advice? Can I use Hexarelin for my health?
No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.
Where do I find Hexarelin specs, purity certificates and pricing?
Open the shop listing via “View product details.” There you will see batch specs, the Certificate of Analysis (COA), concentration, purity grade, and available SKUs with current pricing.
Related peptide guides
Other compounds researchers often read about alongside Hexarelin.
Scientific sources & further reading
Primary literature and registries for Hexarelin, plus mainstream coverage of the peptide category. Research use only - not medical advice.
Databases & literature:
Peptides in the news:
Ready to order? View full product specs
Access concentration, batch info, variants, and current pricing on our shop.
Also known as: Examorelin, EP-23905, MF-6003, Hexarelin Acetate, His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2
Premium research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical with a Certificate of Analysis on every lot. Shipped lab-direct, discreet and cold-chain, worldwide. For laboratory research use only.
Shop
Learn
Company
Support
Ways to Pay
Shop by Compound
Shop by Goal
Ships worldwide
Research use only (RUO). All products are sold strictly for laboratory and research purposes — not for human or veterinary consumption. Purchasers must be 21 or older.
All rights reserved. Copyright of New-U held with Hilxera Distribution Services LLC 2026.
Website & business operated by Hilxera Distribution Services LLC. Registered in Wyoming, ID: 2026-001928701.
© 2026 New-U Research Compounds · new-u.io · @new.u.io