Buy Pancragen (KEDW) Peptide Bioregulator

Every batch ships straight from the lab that synthesises it — sealed, tamper-evident. Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.

Order a sealed 10-vial research pack , or add a single-vial laboratory sample alongside your pack to evaluate a compound at smaller scale first. Same source — scaled to whatever your research needs.

Scientific Research Context

What the published literature on Pancragen examines. These are findings about the compound in the studies cited, not claims about the supplied material.

Differentiation factors in pancreatic cells

In cultures of pancreatic cells from young and aged sources, Pancragen was reported to raise Pdx1 and Ptf1a (acinar) and Pdx1, Pax6, Pax4, Foxa2 and Nkx2.2 (islet) expression; in aged human pancreatic cultures, MMP2, MMP9, serotonin, CD79a, Mcl1, PCNA and Ki67 rose and p53 fell. [in vitro]

Rat model: glucose and capillary endpoints

In streptozotocin-treated rats, oral Pancragen was reported to lower blood glucose and to normalise capillary endothelial adhesion, but not capillary permeability. [animal, rat]

Old rhesus monkeys

In old female rhesus monkeys, the age-related slower glucose disappearance and altered insulin and C-peptide peaks were reported to move toward the young pattern after a course, partly persisting for three weeks. [animal, primate]

Tissue matching in explants

In rat explants of heart, lung, prostate and pancreas, Pancragen stimulated growth of pancreatic tissue alongside the three other peptides on their own tissues. [ex vivo, rat tissue]

Overview

In short: Pancragen (Lys-Glu-Asp-Trp, "KEDW") is a four-residue synthetic peptide from the Khavinson bioregulator family, studied for differentiation markers in pancreatic cell cultures and for glucose and endocrine endpoints in animal models.

Key research facts

Synthetic Lys-Glu-Asp-Trp (KEDW) tetrapeptide from the Khavinson short-peptide lineage

Studied for differentiation factors (Pdx1, Ptf1a, Pax4, Pax6, Foxa2, Nkx2.2) in cultured pancreatic cells

Examined in a rat model and in old rhesus monkeys for glucose and endocrine endpoints

Used as the comparator peptide in the bronchial-epithelium work on Bronchogen

Shares its first three residues with Vesugen (Lys-Glu-Asp)

These points summarise lab themes, not human outcomes.

KEDW is Vesugen (Lys-Glu-Asp) with a tryptophan at the end. In the programme's tissue-matching scheme it is the pancreas peptide, assigned from experiments in a rodent diabetes model. The patent cites insulin-potentiating peptides as the prior-art prototype and says activity was found experimentally; it does not describe isolation from pancreatic tissue.

The record covers three kinds of study. In a streptozotocin rat model, oral administration was reported to lower blood glucose and to normalise capillary endothelial adhesion but not capillary permeability. In old female rhesus monkeys, the age-related pattern of slower glucose clearance and altered insulin and C-peptide peaks was reported to shift toward the young pattern after a course, partly persisting three weeks later. In cultured pancreatic cells from young and aged sources, differentiation-factor expression rose.

It is supplied here as a lyophilised research powder for in-vitro and preclinical use. No analytical report for the supplied material has been published yet, so this page quotes no purity figure and no molecular weight.

Research class: Synthetic short-peptide bioregulator (Khavinson family)

Sequence: Lys-Glu-Asp-Trp (KEDW)

Research focus: Pancreatic cell cultures; glucose and endocrine endpoints in rodent and primate models

Evidence base: Cell-culture, rodent and monkey studies from one research network; no human trial found

Proposed Mechanism

Pancragen is studied as a tissue-matched modulator of differentiation-factor expression. The proposed model is DNA or histone binding in the nucleus; the evidence is expression data in culture, docking and fluorescence assays.

Pathway Effect Why it matters Pancreatic differentiation factors Pdx1, Ptf1a, Pax4, Pax6, Foxa2 and Nkx2.2 raised in cultured pancreatic cells Ties the effect to the tissue of origin; reported in culture only Aged-culture markers MMP2, MMP9, Ki67, PCNA and Mcl1 up and p53 down in aged human pancreatic cultures Used by the authors as an age-related-decline model DNA interaction (in silico) Molecular mechanics suggested groove binding at a putative GGCAG site; a later review gives a different site The proposed sites disagree; a hypothesis, not a measurement Histone binding Fluorescence quenching with FITC-labelled wheat histones Cell-free support for a chromatin interaction; plant proteins

Deeper dive for scientific readers

The Khavinson model proposes that very short peptides reach the nucleus and bind DNA or histones. Pancragen's evidence is a set of expression readouts in pancreatic cultures, a rat model, a primate study and in-silico or cell-free binding work. The proposed DNA binding site differs between sources (a molecular-mechanics study suggests GGCAG, a review citing an unindexed paper gives ACCT), so no specific site should be treated as established. A small report in elderly people exists, but its design is not stated in the abstract and it is not summarised here. No trial is registered.

Common Questions People Are Asking

What is Pancragen?

Pancragen is the name used for the synthetic tetrapeptide Lys-Glu-Asp-Trp (KEDW), developed in the Khavinson short-peptide programme and paired with the pancreas. It is supplied here as a laboratory research powder only.

Why does this page give no molecular weight?

The patent and primary papers define Pancragen with an amidated C-terminus (Lys-Glu-Asp-Trp-NH2), while some sources give the free acid, and the two have different formulas and masses. The terminal form of the supplied material has not been confirmed by a batch report, so only the sequence is published.

What does the research on Pancragen show?

In cultured pancreatic cells it was reported to raise differentiation-factor expression. In a rat model and in old rhesus monkeys, glucose and endocrine endpoints were reported to move. All of it is preclinical and from one research network.

Is there a Certificate of Analysis for Pancragen?

Not yet. No independent analytical report has been published for this material, so no purity figure is quoted.

Is there human data on Pancragen?

One small human report exists, but its design is not stated in the abstract and no trial is registered, so it is not summarised here. Pancragen is sold strictly for in-vitro and preclinical research, not for human or veterinary use.

Where can I buy Pancragen?

Right here - Pancragen is supplied directly by New-U Research Compounds on this page, as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.

How much does Pancragen cost?

Pancragen pricing is shown live on this page, per pack size - 10-vial research packs as standard, with single-vial sample options on selected compounds. Shipping is free on orders over $350.

How do I buy Pancragen?

Add the Pancragen pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step.

What payment methods can I use to buy Pancragen?

At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.

How fast is shipping, and do you ship worldwide?

Yes - we ship worldwide in discreet, unmarked, tracked packaging; lyophilised peptides are stable through the tracked transit window. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.

Is it legal to buy Pancragen?

In the United States, Pancragen is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction - buyers are responsible for compliance in their own region.

Research use only - all claims made on this site are for testing and research use only.

Pharmacokinetics

Stability Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Notes Laboratory research material. No human dosing exists for this compound and none is published or recommended here.

Evidence Tier

Overall: Tier 3: Limited / anecdotal

Pancragen has a preclinical record from one research network: cell cultures, a rat model and a monkey study. The peptide-specific papers are mostly in Russian-language journals or short Bulletin reports, and none has been replicated independently. A small human report exists but its design cannot be verified from the abstract and no trial is registered. It is supplied as unapproved laboratory material.

Tier 2 · Animal

Blood glucose and capillary endothelial adhesion in a streptozotocin rat model

Glucose clearance and insulin and C-peptide responses in old female rhesus monkeys

Growth of rat pancreatic explants in organotypic culture

Databases & peer-reviewed sources

Last reviewed: 13 October 2026 · New-U Research Compounds

Khavinson VKh, Gavrisheva NA, Malinin VV, et al. Effect of pancragen on blood glucose level, capillary permeability and adhesion in rats with experimental diabetes mellitus. Bull Exp Biol Med 2007. · 2007 · PMID: 18642713 · DOI: 10.1007/s10517-007-0377-3

Khavinson VKh, Durnova AO, Polyakova VO, et al. Effects of pancragen on the differentiation of pancreatic cells during their ageing. Bull Exp Biol Med 2013. · 2013 · PMID: 23486591 · DOI: 10.1007/s10517-013-1987-6

Goncharova ND, Ivanova LG, Oganian TE, et al. Impact of tetrapeptide pancragen on endocrine function of the pancreas in old monkeys. Adv Gerontol 2014. · 2014 · PMID: 25946840

Khavinson VKh, Linkova NS, Polyakova VO, et al. Peptides tissue-specifically stimulate cell differentiation during their aging. Bull Exp Biol Med 2012. · 2012 · PMID: 22808515 · DOI: 10.1007/s10517-012-1664-1

Tarnovskaya SI, Yakutseni PP, Khavinson VKh. Study of interactions between DNA and tetrapeptides using methods of molecular mechanics. Bull Exp Biol Med 2014. · 2014 · PMID: 24770759 · DOI: 10.1007/s10517-014-2426-z

Zakutskii AN, Chalisova NI, Ryzhak GA, et al. The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats. Adv Gerontol 2006. · 2006 · PMID: 17152728

Khavinson V, Linkova N, Kozhevnikova E, et al. Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers. Int J Mol Sci 2022. · 2022 · PMID: 35887081 · DOI: 10.3390/ijms23147733

PubMed: peer-reviewed literature on Pancragen

ClinicalTrials.gov: registered studies on Pancragen

Pancragen: Wikipedia (search)

WebMD: consumer health reference

BBC News: Health

CNN Health: “Peptides: what to know about the wellness trend”

Sky News: “Can peptides make America healthy again?”

Sky News: “Inside the exploding US peptides craze” (video)

Sky News Australia: “Black market peptide trade explodes as influencers fuel uptick in use”

Sky News Australia: “Backyard peptide boom sparks alarm” (video)

Sky News Australia: “Oprah reveals struggle with shame of weight-loss drugs”

Key Characteristics

Four-residue peptide: Lys-Glu-Asp-Trp (KEDW)

Vesugen (Lys-Glu-Asp) plus a C-terminal tryptophan

The primary literature defines it with a C-terminal amide; the supplied form is unconfirmed, so no molecular weight is quoted

Pancreatic culture, rat and rhesus-monkey studies

No registered trial; evidence from one research network

Supplied as 10 × 20 mg lyophilised vials; no analytical report published yet

Specifications

Sequence Lys-Glu-Asp-Trp (KEDW) Residues 4 Form Lyophilised powder Pack 10 vials × 20 mg Family Khavinson short-peptide bioregulator Analytical report None published yet Storage Lyophilised: −20 °C freezer. Reconstituted: 1-6 °C, away from light.

About Pancragen (KEDW): Short-Peptide Bioregulator Research Guide

Pancragen appears in PubMed from 2006, and the 2007 rat study was among the first to describe it. The patent that covers it (US 7,491,703) has a Russian priority date of December 2003 and was granted in the United States in 2009. It is the pancreas member of the Khavinson set, alongside Cardiogen for heart, Bronchogen for lung and Prostamax for prostate, all of which were run side by side in rat explant cultures.

One technical point matters for anyone comparing sources. The patent, the MeSH record and the primary papers define Pancragen as Lys-Glu-Asp-Trp-NH2, with an amidated C-terminus. Some sources list the free acid, which has a different formula and mass. Because the supplied material's terminal form is not confirmed by a batch report, this page publishes the sequence only and leaves out the formula and molecular weight rather than guess.

New-U Research Compounds supplies Pancragen as a lyophilised research powder in sealed 10-vial packs of 20 mg vials. No analytical report for the supplied material has been published yet, and this page makes no purity or certificate claim. It is for in-vitro and preclinical research only and nothing here is medical advice.

Khavinson VKh, Gavrisheva NA, Malinin VV, et al. Effect of pancragen on blood glucose level, capillary permeability and adhesion in rats with experimental diabetes mellitus. Bull Exp Biol Med 2007.

Khavinson VKh, Durnova AO, Polyakova VO, et al. Effects of pancragen on the differentiation of pancreatic cells during their ageing. Bull Exp Biol Med 2013.

Goncharova ND, Ivanova LG, Oganian TE, et al. Impact of tetrapeptide pancragen on endocrine function of the pancreas in old monkeys. Adv Gerontol 2014.

Khavinson VKh, Linkova NS, Polyakova VO, et al. Peptides tissue-specifically stimulate cell differentiation during their aging. Bull Exp Biol Med 2012.

Customer Reviews

No customer reviews yet - be the first to share your experience.

More in Metabolic / Longevity

Metabolic / Longevity MOTS-C MOTS-c mitochondrial-derived peptide activates AMPK via folate-AICAR pathway to regulate glucose metabolism, insulin sensitivity, and lipid oxidation. MOTS-C →

Metabolic / Longevity 5-Amino-1MQ 5-Amino-1MQ is a selective NNMT inhibitor that preserves intracellular NAD+ and SAM pools by blocking nicotinamide methylation in adipose tissue. 5-Amino-1MQ →

Metabolic / Longevity Epitalon Epitalon (AEDG) is a synthetic tetrapeptide telomerase activator that upregulates hTERT expression to elongate telomeres in human somatic cells. Epitalon →

Metabolic / Longevity FOXO4-DRI FOXO4-DRI is a D-retro-inverso senolytic peptide that disrupts the FOXO4-p53 nuclear interaction to selectively induce apoptosis in senescent cells. FOXO4-DRI →

Metabolic / Longevity SS-31 SS-31 (Elamipretide) is a mitochondria-targeted tetrapeptide that concentrates in the inner mitochondrial membrane, binds cardiolipin, and restores electron transport chain efficiency in models of mitochondrial dysfunction. SS-31 →

Metabolic / Longevity Cartalax Cartalax (Ala-Glu-Asp / AED) is a synthetic short-peptide bioregulator from the Khavinson cytogen family, studied for tissue-specific gene modulation in cartilage and connective-tissue cell cultures. Cartalax →

Pancragen vs related Metabolic / Longevity compounds

Compound Price Purity spec COA Pancragen from $230 Not published On request MOTS-C from $156 >99% HPLC 2 published batches 5-Amino-1MQ from $93 >99% HPLC On request

Descriptive catalog comparison for research sourcing decisions - not dosing guidance.

More on Pancragen

Metabolic Research research compounds

Pancragen research guide

Research this compound

Research guide Pancragen research guide Pancragen is studied as a tissue-matched modulator of differentiation-factor expression. Read the guide →

Part of the Cognitive & longevity research research area — explore related compounds, guides and sources.

From our community

What people say on Facebook

PRECISION. PURITY. PERFORMANCE.

Research peptides. Third-party Certificates of Analysis (Janoshik Analytical & Freedom Diagnostics) are published on the website. Supplied strictly for laboratory research use.

Shop

All research compounds

Price list

Where to buy peptides

Research