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5-Amino-1MQ
5-Amino-1MQ is a selective NNMT inhibitor that preserves intracellular NAD+ and SAM pools by blocking nicotinamide methylation in adipose tissue.
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Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.
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Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.
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5-Amino-1MQ
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What It's Researched For
In plain terms, 5-Amino-1MQ is studied mainly as a fat-cell and cellular-energy compound. Here is what that looks like across the research.
Fat loss & metabolism
Animal studies look at whether blocking a fat-tissue enzyme shrinks fat cells and lowers body weight in diet-induced obesity models.
Energy & cellular fuel (NAD+)
Research explores how it protects the cell NAD+ pool, a molecule central to how cells make and manage energy.
Muscle strength
Animal studies look at improved grip strength in older mice, an unusual finding for a compound aimed at fat metabolism.
Metabolic ageing research
Preclinical work studies the enzyme it targets as a driver of age-related metabolic slowdown.
Overview
In short: 5-Amino-1MQ is a selective NNMT inhibitor small molecule that preserves intracellular NAD+ and SAM pools, reduces adipocyte hypertrophy, and improves grip strength in diet-induced obesity models.
Key research facts
These points summarise lab themes, not human outcomes.
5-Amino-1MQ is not actually a peptide - it is a small membrane-permeable molecule that blocks an enzyme called nicotinamide N-methyltransferase (NNMT). NNMT normally methylates nicotinamide using SAM as the methyl donor, and in obese or aged tissue it is frequently overactive, acting as a "methyl sink" that drains both NAD+ and SAM pools.
By selectively shutting off NNMT, 5-Amino-1MQ frees up nicotinamide for NAD+ biosynthesis and preserves SAM for the rest of the methylation reactions that cells need. The downstream result, in preclinical work, is reduced adipocyte size, lower body weight, and improved skeletal muscle function in diet-induced obesity models.
Because 5-Amino-1MQ is an orally bioavailable small molecule, it differs from most peptides on this site in both structure and handling. It is supplied as a research-grade material for in-vitro and preclinical study of NNMT pharmacology and metabolic regulation.
Mechanism of Action
5-Amino-1MQ blocks the NNMT enzyme, preserving intracellular NAD+ and SAM and preventing the methyl-sink effect that drives metabolic dysfunction in obese tissue.
Neelakantan et al. (Biochemical Pharmacology, 2018) developed 5-Amino-1MQ as a selective NNMT inhibitor that spares closely related SAM-dependent methyltransferases. A follow-up study (Neelakantan et al., PNAS, 2022) reported reduced body weight, white adipose mass, adipocyte size, and improved grip strength in high-fat-diet mice treated with 5-Amino-1MQ. Rat pharmacokinetics show Cmax 2252 ng/mL, AUC 14431 h·ng/mL, IV t½ 3.8 h, oral t½ 6.9 h, and oral bioavailability 38.4% - all unusually favourable for a small molecule metabolic compound.
Common Questions People Are Asking
What is 5-Amino-1MQ used for in research?
In the literature 5-Amino-1MQ is used as a selective NNMT inhibitor tool compound to study fat-cell metabolism, NAD+ and SAM biology, and diet-induced obesity. Preclinical mouse studies have looked at whether blocking NNMT shrinks adipocytes, lowers body weight, and improves glucose handling.
Is 5-Amino-1MQ a peptide?
No - it is a small molecule (5-amino-1-methylquinolinium) not a peptide. It is included in the research metabolic toolkit because it targets an enzyme pathway (NNMT) that affects the same NAD+ and SAM pools that peptide-based metabolic research often tries to influence.
How does NNMT inhibition relate to NAD+?
NNMT uses nicotinamide as its substrate to produce 1-methylnicotinamide. Every nicotinamide molecule that gets methylated is one that can no longer be recycled into NAD+. When NNMT is overactive (as in obese adipose tissue), it drains the nicotinamide pool and limits NAD+ biosynthesis. Blocking NNMT with 5-Amino-1MQ preserves nicotinamide for NAD+ regeneration.
What does the research actually show?
The data is preclinical. In high-fat-diet mouse models, 5-Amino-1MQ has been reported to reduce body weight, white adipose mass, and adipocyte size, and a 2024 study found NNMT inhibition improved glucose tolerance and fatty-liver markers in diet-induced obese mice without reducing food intake - pointing to an adipose/energy-expenditure mechanism rather than appetite suppression. No human clinical efficacy has been established.
What half-life and oral bioavailability appear in the literature?
Rat pharmacokinetic studies describe roughly 38% oral bioavailability with a plasma half-life around 3.8 h IV and 6.9 h oral, and very high water solubility (>100 mg/mL). That oral profile is unusual for a metabolic compound and is one reason it is studied with once-daily oral protocols. No human PK data has been published.
How is 5-Amino-1MQ different from MOTS-c?
Both are studied for metabolism, but they are structurally and mechanistically different. 5-Amino-1MQ is a small-molecule NNMT inhibitor that preserves NAD+/SAM pools, while MOTS-c is a 16-amino-acid mitochondrial-derived peptide that activates AMPK as an "exercise mimetic". One is an enzyme inhibitor taken orally; the other is an injectable signalling peptide.
How should 5-Amino-1MQ be stored?
Unlike most peptides on this site, 5-Amino-1MQ is a stable small molecule that does not require freezing. Store it in a cool, dry place at room temperature; it is shelf-stable in that state.
Where can I buy 5-Amino-1MQ?
Right here - 5-Amino-1MQ is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.
How much does 5-Amino-1MQ cost?
5-Amino-1MQ pricing is shown live on this page, per pack size - 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $350.
Is 5-Amino-1MQ third-party tested?
Yes. Every 5-Amino-1MQ batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy 5-Amino-1MQ?
Add the 5-Amino-1MQ pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step. Every order ships with its batch Certificate of Analysis (COA).
What payment methods can I use to buy 5-Amino-1MQ?
At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes - we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.
Is it legal to buy 5-Amino-1MQ?
In the United States, 5-Amino-1MQ is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction - buyers are responsible for compliance in their own region.
Research use only - all claims made on this site are for testing and research use only.
Pharmacokinetics
Evidence Tier
Overall: Tier 2: Animal / preclinical
5-Amino-1MQ is a small-molecule NNMT inhibitor (not a peptide). Its evidence base is entirely preclinical - diet-induced-obesity rodent models plus rat pharmacokinetics - with no published human data. It is not approved for any indication in any jurisdiction and is supplied as unapproved laboratory material.
Tier 2 · Animal
Certificates, databases & peer-reviewed sources
Last reviewed: 16 June 2026 · New-U Research Compounds
Key Characteristics
Specifications
About 5-Amino-1MQ: NNMT Inhibitor Metabolic Research Guide
5-Amino-1MQ is a bit of an outlier on a peptide site - it is actually a small molecule rather than a peptide. But it belongs in the metabolic and fat-loss research toolkit for the same reason NAD+ precursors and AMPK activators do: it is a selective NNMT inhibitor, and NNMT (nicotinamide N-methyltransferase) overactivity is increasingly recognised as a driver of obesity, insulin resistance, and aging-related metabolic decline.
The enzyme NNMT methylates nicotinamide using SAM as a methyl donor, producing 1-methylnicotinamide. In healthy lean tissue that reaction runs at baseline, but in obese adipose and aged tissue it is often dramatically upregulated - which drains the nicotinamide pool that cells need for NAD+ biosynthesis and the SAM pool they need for essentially every other methylation reaction. 5-Amino-1MQ blocks that drain at the source, and a 2024 study in Diabetes, Obesity and Metabolism reported that NNMT inhibition with 5A1MQ limited body-weight and fat-mass gain and improved glucose tolerance and liver markers in diet-induced obese mice.
New-U Research Compounds supplies 5-Amino-1MQ as a research-grade material at >99% purity, independently verified by third-party labs. All material is strictly for in-vitro and preclinical research use. The compound is not approved for human therapeutic use, and nothing on this page is medical advice.
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