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Epitalon
Pick your pack · how long it lasts
At 70 mg/wk — select pack size
1 × 10-vial pack required for packing — samples add on to any pack
Lab-direct quality — full packs or single-vial samples
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a batch-linked Certificate of Analysis. Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a full sealed 10-vial research pack for a complete study supply, or add a single-vial sample alongside your pack to trial a new compound first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
In plain terms, Epitalon is studied mainly as a cellular-ageing and longevity compound. Here is what that looks like across the research.
Cellular ageing & longevity
Research explores how it switches the telomerase enzyme back on, lengthening the protective caps on chromosomes that normally shorten as cells age.
Cell lifespan research
In classic cell-culture studies it let human cells keep dividing well past their usual limit, a key longevity-research finding.
Sleep & melatonin signalling
Animal studies look at restored melatonin output from the pineal gland, the hormone tied to the sleep-wake rhythm.
Senescence & ageing-biology tool
Widely used as a reference compound in research on how and why cells stop dividing as they grow old.
Overview
Epitalon (also spelled Epithalon) is a four-amino-acid tetrapeptide that reactivates telomerase expression in human somatic cells, extending replicative lifespan beyond the Hayflick limit in classic fibroblast aging experiments.
Epitalon is a very small peptide - just four amino acids (Ala-Glu-Asp-Gly) - identified as the bioactive core of a larger pineal extract called epithalamin. It was developed by Vladimir Khavinson's group at the St. Petersburg Institute of Bioregulation and Gerontology as part of a decades-long Russian research programme on "bioregulator peptides" - short peptides that seemed to reset age-related gene expression.
What makes Epitalon interesting in longevity research is its effect on telomerase. Human somatic cells typically stop expressing hTERT (the catalytic subunit of telomerase) as they mature, which means their telomeres shorten with each division until they hit the Hayflick limit and stop dividing. Epitalon upregulates hTERT expression and elongates telomeres in human fibroblasts, extending proliferative lifespan in experimental models.
Epitalon has become a staple of longevity and telomere biology research. Supplied here as sterile lyophilised powder for in-vitro and preclinical research - it is not an approved medicine anywhere in the world.
Mechanism of Action
Epitalon binds specific DNA motifs and histone proteins in the hTERT promoter region, switching on telomerase expression and allowing telomeres to lengthen in cells that had turned the enzyme off.
Khavinson et al. (Bulletin of Experimental Biology and Medicine, 2003) reported 12-fold hTERT upregulation at 1 μg/mL in 21NT breast epithelial cells. A parallel study (Khavinson et al., Neuroendocrinology Letters, 2003) showed extended proliferative capacity of human fetal fibroblasts beyond passage 44, versus senescence at passage 34 in controls. The DNA-binding mechanism involves the ATTTC motif in the hTERT promoter and formation of complexes with histones H1/6 (ΔG = −64.51 kcal/mol). No formal human pharmacokinetic data has been published.
Common Questions People Are Asking
What is Epitalon used for in research?
Epitalon (AEDG) is studied as a telomerase-activating bioregulator peptide and a tool compound in telomere biology, cellular-senescence, and longevity research. Cell-culture work has examined hTERT reactivation and telomere elongation, while animal studies have looked at pineal melatonin output and lifespan endpoints. It is supplied here for laboratory research only and is not for human use.
Is "Epitalon" the same as "Epithalon"?
Yes - the two spellings refer to the same tetrapeptide (Ala-Glu-Asp-Gly). "Epitalon" and "Epithalon" are interchangeable transliterations of the Russian name. You will also see "Epithalone" and "AEDG peptide" in the literature, all referring to the same compound.
How does Epitalon activate telomerase?
Epitalon binds specific DNA motifs (the ATTTC element) in the hTERT promoter and forms complexes with histone proteins, which favours transcription of hTERT - the catalytic subunit of telomerase. Re-expressing hTERT in somatic cells that had silenced it lets telomeres lengthen rather than shorten with each division. This is a promoter-level mechanism rather than indirect signalling, which is unusual for such a small peptide.
Does Epitalon actually extend lifespan in humans?
That is a longevity research question that has not been definitively answered. The cell-culture telomere-elongation data is clear, and there are animal studies showing increased maximum lifespan. Human longevity data is limited to small studies and the related pineal extract epithalamin, not the synthetic AEDG peptide. It remains a research compound, not a validated longevity therapy.
What dosing pattern appears in the published protocols?
Published Russian research protocols describe a pulsed pattern - around 5-10 mg subcutaneously once daily for 10-20 consecutive days, followed by a 4-6 month rest period before the next cycle. This pulse-then-rest design mirrors the original animal study schedules. These figures are descriptive of the literature and are not a recommendation; the material is for laboratory research only.
How is Epitalon different from FOXO4-DRI?
Both are studied in aging research but work on opposite ends of the problem. Epitalon is a telomerase activator that aims to slow telomere-driven senescence by keeping cells dividing, whereas FOXO4-DRI is a senolytic that selectively kills cells that have already become senescent. One delays the onset of senescence; the other clears existing "zombie" cells.
How should Epitalon be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The tetrapeptide is small and simple, so it tolerates standard peptide handling well within the normal usage window.
Where can I buy Epitalon?
Right here — Epitalon is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging. Strictly for laboratory research use only — not for human use.
How much does Epitalon cost?
Epitalon pricing is shown live on this page, per pack size — 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $300.
Is Epitalon third-party tested?
Yes. Every Epitalon batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy Epitalon?
Add the Epitalon pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). Epitalon is supplied strictly for laboratory research use only, not for human or veterinary use.
What payment methods can I use to buy Epitalon?
At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.
Is it legal to buy Epitalon?
In the United States, Epitalon is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction — buyers are responsible for compliance in their own region.
Pharmacokinetics
Evidence Tier
Overall: Mixed (human + animal)
Epitalon's best-documented mechanism data are in-vitro — hTERT reactivation and telomere elongation in human cell culture (Khavinson et al., Bull Exp Biol Med, 2003; PMID 12937682). Animal work reports pineal melatonin restoration, and human data are limited to small longevity studies of variable rigor, much of which concerns the related pineal extract epithalamin rather than the synthetic AEDG tetrapeptide. Epitalon has no Western regulatory approval and is supplied as unapproved laboratory material.
Tier 1 · Human clinical
Tier 2 · Animal
Source References & Further Reading
Last reviewed: 16 June 2026 · New-U Research Compounds
Key Characteristics
Specifications
About Epitalon (Epithalon): Telomerase Activator & Longevity Research Guide
Epitalon comes from a distinct research lineage - the Russian "bioregulator peptide" programme led by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. The programme's central hypothesis was that organs produce very short peptides (two to four amino acids) that regulate their own gene expression, and that supplementing those peptides could reset age-related expression patterns in target tissues. Epitalon - the synthetic AEDG tetrapeptide (Ala-Glu-Asp-Gly) - is the pineal-derived member of that family.
The mechanism that drew mainstream attention is telomerase reactivation. In a foundational in-vitro study (Khavinson et al., Bull Exp Biol Med, 2003), Epithalon induced telomerase catalytic-subunit (hTERT) expression, telomerase activity, and telomere elongation in human somatic cells, and extended the proliferative capacity of human fetal fibroblasts past the Hayflick limit - the normal boundary at which somatic cells stop dividing due to telomere shortening. That gives it an unusual place in the longevity and telomere-biology research toolkit.
New-U Research Compounds supplies Epitalon (also often spelled Epithalon) as a research-grade lyophilised powder at 98.7% HPLC purity, verified by independent third-party labs (Janoshik, task #167655, May 2026). All material is strictly for in-vitro and preclinical research use. Epitalon is not approved for human therapeutic use in any major jurisdiction, and nothing on this page constitutes medical advice.
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