Buy Chonluten (EDG, T-34) Peptide Bioregulator

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Order a sealed 10-vial research pack , or add a single-vial laboratory sample alongside your pack to evaluate a compound at smaller scale first. Same source — scaled to whatever your research needs.

Scientific Research Context

What the published literature on Chonluten examines. These are findings about the compound in the studies cited, not claims about the supplied material.

Monocyte signalling and cytokines

In the human THP-1 monocyte line, Chonluten was reported to modulate MAP-kinase tyrosine phosphorylation and to reduce LPS-induced TNF. Across the five peptides tested, LPS-stimulated TNF and IL-6 expression in differentiated cells and THP-1 adhesion to LPS-activated HUVECs fell; Chonluten alone gave a slight TNF release and a higher apoptotic fraction. [in vitro, human cell line]

Rat gastric model

In a chemically induced gastric-injury model in rats, T-34 was reported to normalise mRNA expression of antioxidant and anti-inflammatory proteins. The abstract names no genes. [animal, rat]

A null result in skin explants

In skin explants from young rats, T-34 did not stimulate proliferation, while T-32, T-33, T-36 and T-38 did. [ex vivo, rat tissue]

Transporter docking

Docking predicted EDG to bind LAT1 (score -43.40), LAT2 and PEPT1, listing it among the best ligands of 26 ultrashort peptides. No transport was measured. [in silico]

Overview

In short: Chonluten (Glu-Asp-Gly, "EDG") is a three-residue synthetic peptide from the Khavinson bioregulator family, studied for cytokine and signalling markers in a monocyte cell line and for gene expression in a rat gastric model.

Key research facts

Synthetic Glu-Asp-Gly (EDG) tripeptide from the Khavinson short-peptide lineage, lab code T-34

Studied for MAP-kinase signalling and LPS-induced TNF and IL-6 expression in THP-1 monocyte cells

Examined for antioxidant and anti-inflammatory gene expression in a rat gastric model

Includes a reported null result for skin-explant proliferation

Shares its Glu-Asp pair with Pinealon (Glu-Asp-Arg) and Epitalon (Ala-Glu-Asp-Gly)

These points summarise lab themes, not human outcomes.

EDG is the last three residues of Epitalon (Ala-Glu-Asp-Gly) and differs from Pinealon (Glu-Asp-Arg) only at the C-terminus. No paper found describes it as a fragment of Epitalon, so that relationship is a sequence observation. In the lab papers it carries the code T-34, set beside T-32 (Glu-Asp-Ala), T-33 (Glu-Asp-Arg), T-36 (Glu-Asp-Pro) and T-38 (Lys-Glu-Asp).

The best-described experiment is a 2022 study in the human THP-1 monocyte line. Chonluten was reported to modulate MAP-kinase tyrosine phosphorylation along with four other peptides and to reduce LPS-induced TNF production; the Results note that it alone gave a slight TNF release and a higher apoptotic fraction than the other four. In a rat gastric model, T-34 was reported to normalise mRNA expression of antioxidant and anti-inflammatory proteins. In skin explants from young rats it did not stimulate proliferation where four related tripeptides did.

It is supplied here as a lyophilised research powder for in-vitro and preclinical use. No analytical report for the supplied material has been published yet, so this page quotes no purity figure.

Research class: Synthetic short-peptide bioregulator (Khavinson family)

Sequence: Glu-Asp-Gly (EDG)

Research focus: Monocyte cell-line signalling and cytokines; gene expression in rat gastric tissue

Evidence base: Cell-line, rat and in-silico studies; four primary papers; no human data

Proposed Mechanism

Chonluten is studied as an ultrashort peptide that may modulate inflammatory and antioxidant gene expression. The cell-line data show signalling and cytokine effects with some unexpected readouts; the mechanism itself is a hypothesis.

Pathway Effect Why it matters MAP-kinase signalling Tyrosine phosphorylation of MAP kinases modulated in THP-1 cells A proliferation-signalling readout shared with the four other peptides tested Cytokine expression LPS-induced TNF and IL-6 reduced across the peptide set; Chonluten itself gave a slight TNF release Mixed for this peptide alone; the abstract and Results do not read the same way Antioxidant and anti-inflammatory genes mRNA expression normalised in a rat gastric model The only in-vivo gene-expression result, from a single abstract Transporter docking Strong predicted binding to LAT1 Computational ranking only

Deeper dive for scientific readers

The Khavinson model proposes that ultrashort peptides are transported into cells and act on chromatin. For Chonluten the supporting measurements are signalling and cytokine readouts in one monocyte line, one rat abstract and docking scores. The literature is inconsistent on tissue pairing: the 2022 monocyte paper calls it derived from bronchial epithelial cells and a "synthetic bronchial bio-regulator" while using monocytes and endothelial cells only; the group's own 2022 review table lists it as a gastroprotector and stress protector, citing the gastric-model paper and the patent. The lung work in this family concerns Bronchogen.

Common Questions People Are Asking

What is Chonluten?

Chonluten is the name used for the synthetic tripeptide Glu-Asp-Gly (EDG), lab code T-34, in the Khavinson short-peptide literature. It is supplied here as a laboratory research powder only.

Which tissue is Chonluten matched to?

Sources disagree. One 2022 paper calls it a bronchial bio-regulator but tests it only in monocytes and endothelial cells; the group's own review table lists it as a gastroprotector and stress protector, citing a rat gastric paper and the patent. This page does not choose between them.

What does the research on Chonluten show?

In a human monocyte line it modulated MAP-kinase signalling and reduced LPS-induced TNF, though it alone gave a slight TNF release. A rat gastric abstract reports normalised antioxidant and anti-inflammatory mRNA, and in skin explants it did not stimulate proliferation. All of it is preclinical.

Is there a Certificate of Analysis for Chonluten?

Not yet. No independent analytical report has been published for this material, so no purity figure is quoted.

Is there human data on Chonluten?

No human study and no registered trial were found. Chonluten is sold strictly for in-vitro and preclinical research, not for human or veterinary use.

Where can I buy Chonluten?

Right here - Chonluten is supplied directly by New-U Research Compounds on this page, as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.

How much does Chonluten cost?

Chonluten pricing is shown live on this page, per pack size - 10-vial research packs as standard, with single-vial sample options on selected compounds. Shipping is free on orders over $350.

How do I buy Chonluten?

Add the Chonluten pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step.

What payment methods can I use to buy Chonluten?

At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.

How fast is shipping, and do you ship worldwide?

Yes - we ship worldwide in discreet, unmarked, tracked packaging; lyophilised peptides are stable through the tracked transit window. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.

Is it legal to buy Chonluten?

In the United States, Chonluten is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction - buyers are responsible for compliance in their own region.

Research use only - all claims made on this site are for testing and research use only.

Pharmacokinetics

Stability Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Notes Laboratory research material. No human dosing exists for this compound and none is published or recommended here.

Evidence Tier

Overall: Tier 3: Limited / anecdotal

Chonluten has a small preclinical record: one cell-line paper, one rat abstract, one explant paper with a null result for this peptide and one docking study. The tissue pairing is inconsistent across sources, there are no human data and no registry record, and none of the work has been replicated independently. It is supplied as unapproved laboratory material.

Tier 2 · Animal

mRNA expression of antioxidant and anti-inflammatory proteins in a rat gastric-injury model

Skin-explant proliferation in young rats (no stimulation by T-34)

Databases & peer-reviewed sources

Last reviewed: 13 October 2026 · New-U Research Compounds

Avolio F, Martinotti S, Khavinson VK, et al. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. Int J Mol Sci 2022. · 2022 · PMID: 35408963 · DOI: 10.3390/ijms23073607

Khavinson VKh, Lin'kova NS, Dudkov AV, et al. Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins. Bull Exp Biol Med 2012. · 2012 · PMID: 22803148 · DOI: 10.1007/s10517-012-1590-2

Voicekhovskaya MA, Chalisova NI, Kontsevaya EA, et al. Effect of bioregulatory tripeptides on the culture of skin cells from young and old rats. Bull Exp Biol Med 2012. · 2012 · PMID: 22803085 · DOI: 10.1007/s10517-012-1527-9

Khavinson VK, Linkova NS, Rudskoy AI, et al. Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters. Biomolecules 2023. · 2023 · PMID: 36979488 · DOI: 10.3390/biom13030552

Khavinson V, Linkova N, Kozhevnikova E, et al. Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers. Int J Mol Sci 2022. · 2022 · PMID: 35887081 · DOI: 10.3390/ijms23147733

PubMed: peer-reviewed literature on Chonluten

ClinicalTrials.gov: registered studies on Chonluten

Chonluten: Wikipedia (search)

WebMD: consumer health reference

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Key Characteristics

Three-residue peptide: Glu-Asp-Gly (EDG), lab code T-34

The last three residues of Epitalon; Pinealon without its C-terminal arginine

Monocyte cell-line signalling and cytokine data; a rat gastric abstract

Tissue pairing inconsistent across sources (bronchial versus gastric)

No human data and no registered trial

Supplied as 10 × 20 mg lyophilised vials; no analytical report published yet

Specifications

Sequence Glu-Asp-Gly (EDG) Residues 3 Molecular Formula C 11 H 17 N 3 O 8 Molecular Weight 319.27 Da (average, free peptide) Form Lyophilised powder Pack 10 vials × 20 mg Family Khavinson short-peptide bioregulator Analytical report None published yet Storage Lyophilised: −20 °C freezer. Reconstituted: 1-6 °C, away from light.

About Chonluten (EDG): Short-Peptide Bioregulator Research Guide

The tripeptide Glu-Asp-Gly was known well before the bioregulator work: the patent calls it prior art, and the MeSH vocabulary has carried it since 1980. What Khavinson and colleagues added was the application. The patent (US 8,071,556 B2) has a priority date of May 2006, and the first peer-reviewed papers on T-34 are from 2012.

The formula C11H17N3O8 and average mass of 319.27 Da here are computed from Glu-Asp-Gly and match the compound record. The "Chonluten" name is a trademark form in at least one paper.

New-U Research Compounds supplies Chonluten as a lyophilised research powder in sealed 10-vial packs of 20 mg vials. No analytical report for the supplied material has been published yet, and this page makes no purity or certificate claim. It is for in-vitro and preclinical research only and nothing here is medical advice.

Avolio F, Martinotti S, Khavinson VK, et al. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. Int J Mol Sci 2022.

Khavinson VKh, Lin'kova NS, Dudkov AV, et al. Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins. Bull Exp Biol Med 2012.

Voicekhovskaya MA, Chalisova NI, Kontsevaya EA, et al. Effect of bioregulatory tripeptides on the culture of skin cells from young and old rats. Bull Exp Biol Med 2012.

Khavinson VK, Linkova NS, Rudskoy AI, et al. Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters. Biomolecules 2023.

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Research guide Chonluten research guide Chonluten is studied as an ultrashort peptide that may modulate inflammatory and antioxidant gene expression. Read the guide →

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