Buy Bronchogen (AEDL) Peptide Bioregulator

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Scientific Research Context

What the published literature on Bronchogen examines. These are findings about the compound in the studies cited, not claims about the supplied material.

Proliferation and apoptosis markers

In cultured human embryonic bronchial epithelial cells, Bronchogen was reported to raise Ki67 and Mcl-1 and lower p53. At passage 14 the Ki67-positive area rose from 4.07% in control to 13.92% with the peptide, while the control tetrapeptide Lys-Glu-Asp-Trp did not change Ki67. [in vitro, human cells]

Lung-lineage gene expression

Expression of NKX2-1, SCGB1A1, SCGB3A2, FOXA1/2, MUC4, MUC5AC and SFTPA1 was reported to change, depending on culture age; CXCL12 and Hoxa3 expression rose more in aged cultures. [in vitro]

DNA interaction

Bronchogen raised the thermal stability of DNA by 3.1 °C and was reported to bind CNG-containing oligonucleotides, with a preference for CTG, unlike Epitalon, Pinealon and Testagen, which preferred CAG. [in vitro, cell-free]

Rat bronchial tissue

In a rat model of nitrogen-dioxide-induced bronchial epithelial remodelling, a month of administration was reported to reverse remodelling features, raise secretory IgA and normalise lavage-cell counts and cytokines. [animal, rat]

Overview

In short: Bronchogen (Ala-Glu-Asp-Leu, "AEDL") is a four-residue synthetic peptide from the Khavinson bioregulator family, studied for gene expression and proliferation markers in bronchial epithelial cell cultures.

Key research facts

Synthetic Ala-Glu-Asp-Leu (AEDL) tetrapeptide from the Khavinson short-peptide lineage

Studied in cultured human bronchial epithelial cells for proliferation and apoptosis markers

Examined for lung-lineage gene expression (NKX2-1, secretoglobins, mucins, surfactant protein A1) in vitro

DNA-binding profile characterised in cell-free melting and fluorescence assays

Compared with Epitalon (Ala-Glu-Asp-Gly), which differs only at the last residue

These points summarise lab themes, not human outcomes.

Bronchogen is built from the same Ala-Glu-Asp stem as Cartalax and Epitalon. Where Epitalon ends in glycine, Bronchogen ends in leucine. The programme matches each short peptide to a tissue, and Bronchogen is the respiratory one: the patent and the experimental papers pair it with bronchial epithelium.

The strongest data are in vitro. In cultured human embryonic bronchial epithelial cells (the FLECH line), Bronchogen was reported to raise the proliferation marker Ki67 and the anti-apoptotic protein Mcl-1 and to lower p53, with the largest Ki67 change in cells at late passage. Expression of lung-lineage genes also changed, and the peptide raised the melting temperature of DNA by 3.1 °C in a cell-free assay. A rat study of nitrogen-dioxide-induced bronchial remodelling reports epithelial and immune-marker changes after a month of administration.

It is supplied here as a lyophilised research powder for in-vitro and preclinical use. No analytical report for the supplied material has been published yet, so this page quotes no purity figure.

Research class: Synthetic short-peptide bioregulator (Khavinson family)

Sequence: Ala-Glu-Asp-Leu (AEDL)

Research focus: Bronchial epithelial cell cultures and rat bronchial tissue

Evidence base: Cell-culture, cell-free and rat studies from one research network; no human data

Proposed Mechanism

Bronchogen is studied as a tissue-matched transcriptional modulator: the proposed model is that it enters bronchial epithelial cell nuclei and binds DNA at CNG-type sequences. The data are in vitro and in silico, so the model remains a hypothesis.

Pathway Effect Why it matters DNA binding Preferential binding to CNG sequences with a CTG preference; DNA melting temperature raised by 3.1 °C The proposed route to gene-level effects; measured cell-free only Proliferation and survival markers Ki67 and Mcl-1 up, p53 down in bronchial epithelial cultures Largest at late passage, where the cultures show age-related decline Lung-lineage transcription NKX2-1, secretoglobin, FOXA, mucin and surfactant-protein genes changed with culture age Ties the effect to the tissue of origin rather than to broad cell growth Chemokine and homeobox markers CXCL12 and Hoxa3 expression stimulated, more strongly in aged cultures Reported in two independent tissue models from the same group

Deeper dive for scientific readers

The Khavinson hypothesis is that ultrashort peptides act as endogenous gene regulators, matched to tissue. For Bronchogen the evidence is a set of cell-culture readouts on a single embryonic bronchial epithelial line, DNA melting and fluorescence experiments, spectroscopy interpreted by the authors as major-groove binding at guanine N7, and a rat inhalation-injury study. The authors describe the "geroprotective" reading of the culture data as a hypothesis for further study, not a measured outcome. No independent laboratory has reproduced the findings and no human study was found.

Common Questions People Are Asking

What is Bronchogen?

Bronchogen is the name used for the synthetic tetrapeptide Ala-Glu-Asp-Leu (AEDL), developed in the Khavinson short-peptide programme and studied in bronchial epithelial cell cultures. It is supplied here as a laboratory research powder only.

Is the sequence AEDL or ADEL?

Most sources, including the patent and the PubChem compound record, give Ala-Glu-Asp-Leu (AEDL). A few papers from the same group print Ala-Asp-Glu-Leu. The composition, formula (C18H30N4O9) and average mass (446.46 Da) are identical either way. This page uses AEDL.

What does the research on Bronchogen show?

In cultured human bronchial epithelial cells it was reported to raise Ki67 and Mcl-1 and lower p53, with larger effects at late passage, and to change lung-lineage gene expression. A rat study reports changes in bronchial epithelium after nitrogen-dioxide exposure. All of it is preclinical and from one research network.

Is there a Certificate of Analysis for Bronchogen?

Not yet. No independent analytical report has been published for this material, so no purity figure is quoted.

Is there human data on Bronchogen?

No human study was found in the literature cited here. Bronchogen is sold strictly for in-vitro and preclinical research, not for human or veterinary use.

Where can I buy Bronchogen?

Right here - Bronchogen is supplied directly by New-U Research Compounds on this page, as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.

How much does Bronchogen cost?

Bronchogen pricing is shown live on this page, per pack size - 10-vial research packs as standard, with single-vial sample options on selected compounds. Shipping is free on orders over $350.

How do I buy Bronchogen?

Add the Bronchogen pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step.

What payment methods can I use to buy Bronchogen?

At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.

How fast is shipping, and do you ship worldwide?

Yes - we ship worldwide in discreet, unmarked, tracked packaging; lyophilised peptides are stable through the tracked transit window. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.

Is it legal to buy Bronchogen?

In the United States, Bronchogen is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction - buyers are responsible for compliance in their own region.

Research use only - all claims made on this site are for testing and research use only.

Pharmacokinetics

Stability Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Notes Laboratory research material. No human dosing exists for this compound and none is published or recommended here.

Evidence Tier

Overall: Tier 3: Limited / anecdotal

Bronchogen has a small preclinical record from one research network: cultured bronchial epithelial cells, cell-free DNA studies and rat models. There are no human data and no independent replication, and one paper's "geroprotective" wording is the authors' hypothesis. It is supplied as unapproved laboratory material.

Tier 2 · Animal

Bronchial epithelial structure, secretory IgA, lavage-cell counts and cytokines in a rat nitrogen-dioxide model (two reports)

Growth of lung explants from young and old rats in organotypic culture

Databases & peer-reviewed sources

Last reviewed: 13 October 2026 · New-U Research Compounds

Khavinson VKh, Tendler SM, Vanyushin BF, et al. Peptide regulation of gene expression and protein synthesis in bronchial epithelium. Lung 2014. · 2014 · PMID: 25015171 · DOI: 10.1007/s00408-014-9620-7

Kuzubova NA, Lebedeva ES, Dvorakovskaya IV, et al. Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology. Bull Exp Biol Med 2015. · 2015 · PMID: 26468022 · DOI: 10.1007/s10517-015-3047-x

Monaselidze JR, Khavinson VKh, Gorgoshidze MZ, et al. Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability. Bull Exp Biol Med 2011. · 2011 · PMID: 21240358 · DOI: 10.1007/s10517-011-1146-x

Khavinson VKh, Linkova NS, Polyakova VO, et al. Peptides tissue-specifically stimulate cell differentiation during their aging. Bull Exp Biol Med 2012. · 2012 · PMID: 22808515 · DOI: 10.1007/s10517-012-1664-1

Fedoreyeva LI, Kireev II, Khavinson VKh, et al. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc) 2011. · 2011 · PMID: 22117547 · DOI: 10.1134/S0006297911110022

Zakutskii AN, Chalisova NI, Ryzhak GA, et al. The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats. Adv Gerontol 2006. · 2006 · PMID: 17152728

PubMed: peer-reviewed literature on Bronchogen

ClinicalTrials.gov: registered studies on Bronchogen

Bronchogen: Wikipedia (search)

WebMD: consumer health reference

BBC News: Health

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Key Characteristics

Four-residue peptide: Ala-Glu-Asp-Leu (AEDL)

Differs from Epitalon (Ala-Glu-Asp-Gly) at the last residue only

Best-characterised in cultured human bronchial epithelial cells

Cell-free DNA melting and oligonucleotide binding data

No human data; evidence from one research network

Supplied as 10 × 20 mg lyophilised vials; no analytical report published yet

Specifications

Sequence Ala-Glu-Asp-Leu (AEDL) Residues 4 Molecular Formula C 18 H 30 N 4 O 9 Molecular Weight 446.46 Da (average, free peptide) Form Lyophilised powder Pack 10 vials × 20 mg Family Khavinson short-peptide bioregulator Analytical report None published yet Storage Lyophilised: −20 °C freezer. Reconstituted: 1-6 °C, away from light.

About Bronchogen (AEDL): Short-Peptide Bioregulator Research Guide

Bronchogen is the respiratory-tissue peptide of the Khavinson programme. The patent that covers it (US 7,625,870 B2) describes classical peptide synthesis of Ala-Glu-Asp-Leu, and the first journal use of the peptide in organotypic rat tissue cultures dates to 2006. A 2014 study in the journal Lung gave the clearest account of what it does to human bronchial epithelial cells in culture.

One detail deserves a plain statement. Most sources, including the patent and the compound record in PubChem, write the sequence as Ala-Glu-Asp-Leu. A few papers from the same group print the order as Ala-Asp-Glu-Leu. Both orders have the same composition and the same formula and mass, and this page follows the patent and PubChem.

New-U Research Compounds supplies Bronchogen as a lyophilised research powder in sealed 10-vial packs of 20 mg vials. No analytical report for the supplied material has been published yet, and this page makes no purity or certificate claim. It is for in-vitro and preclinical research only and nothing here is medical advice.

Khavinson VKh, Tendler SM, Vanyushin BF, et al. Peptide regulation of gene expression and protein synthesis in bronchial epithelium. Lung 2014.

Monaselidze JR, Khavinson VKh, Gorgoshidze MZ, et al. Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability. Bull Exp Biol Med 2011.

Khavinson VKh, Linkova NS, Polyakova VO, et al. Peptides tissue-specifically stimulate cell differentiation during their aging. Bull Exp Biol Med 2012.

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Research guide Bronchogen research guide Bronchogen is studied as a tissue-matched transcriptional modulator: the proposed model is that it enters bronchial epithelial cell nuclei… Read the guide →

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Research peptides. Third-party Certificates of Analysis (Janoshik Analytical & Freedom Diagnostics) are published on the website. Supplied strictly for laboratory research use.

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