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Selank
Selank is a synthetic tuftsin-derived heptapeptide anxiolytic that allosterically modulates GABAA receptors and upregulates hippocampal BDNF expression.
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Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.
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Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.
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Selank
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Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity . Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a sealed 10-vial research pack , or add a single-vial laboratory sample alongside your pack to evaluate a compound at smaller scale first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
In plain terms, Selank is studied as a calming brain peptide for stress and anxiety. Here is what that looks like across the research.
Mood & stress
In clinical research it is investigated for easing anxiety, with calming comparable to standard anti-anxiety drugs but without the heavy sedation or dependence.
Energy & mental clarity
Studied for reducing fatigue and lifting mental energy alongside its calming effect, rather than making people drowsy.
Focus & brain support
Research explores steadier focus and brain-cell support through its effect on a key brain growth signal.
Fast-acting nasal route
Research uses a nasal-drop format where the calming effect is reported to come on within minutes.
Overview
In short: Selank is a Russian anxiolytic heptapeptide derived from the immune peptide tuftsin that produces benzodiazepine-like calming effects through GABAA modulation - without sedation, amnesia, or dependence.
Key research facts
These points summarise lab themes, not human outcomes.
Selank is a short synthetic peptide built on the tetrapeptide tuftsin (residues 289-292 of the IgG heavy chain) with a C-terminal Pro-Gly-Pro extension that protects it from enzymatic degradation. The parent tuftsin is an immunomodulatory signal naturally released during IgG processing, and Selank inherits some of that activity alongside a distinct anxiolytic profile.
What makes Selank interesting clinically is that it calms anxiety with a quality similar to benzodiazepines, but without the usual trade-offs. It does not sedate, does not impair memory, and does not produce dependence or withdrawal - three of the biggest problems with classic anxiolytics. Russian clinical trials compared it directly to medazepam and found comparable efficacy with none of the classic side effects.
Selank is widely used in Russian clinical practice for generalised anxiety and is a common research tool in the anxiolytic peptide literature. Supplied here as sterile lyophilised powder for in-vitro and preclinical research.
Mechanism of Action
Selank allosterically modulates GABAA receptors, raises BDNF in the hippocampus, and shifts monoamine neurotransmitter balance - producing anxiolysis without the sedation or dependence profile of benzodiazepines.
A Russian clinical study (Zozulya et al., Zh Nevrol Psikhiatr Im S S Korsakova, 2008) compared Selank directly with the benzodiazepine medazepam in generalised anxiety disorder and neurasthenia, reporting similar anxiolytic effects but with additional antiasthenic and psychostimulant activity from Selank. Volkova et al. (Frontiers in Pharmacology, 2016) found Selank altered the expression of GABAergic-neurotransmission genes and proposed allosteric modulation of the GABAergic system as a likely mechanism. Plasma clearance is effectively complete within minutes of administration, but like Semax the Pro-Gly-Pro tail extends functional duration far beyond the parent tuftsin (whose half-life is measured in seconds).
Common Questions People Are Asking
What is Selank and how does it work?
Selank is a synthetic seven-amino-acid (heptapeptide) derivative of the immune peptide tuftsin, with a Pro-Gly-Pro tail for stability, studied as an anxiolytic and nootropic research compound. The leading mechanistic hypothesis is allosteric modulation of the GABAergic system - it changes the expression of GABA-related genes rather than binding the GABA-A receptor as a direct agonist - alongside effects on monoamine neurotransmitters. New-U supplies it for laboratory research only.
What does the Selank research actually show?
The headline finding is a Russian clinical study where Selank produced anxiolytic effects similar to the benzodiazepine medazepam, plus additional antiasthenic (anti-fatigue) and psychostimulant activity (Zozulya et al., 2008). Mechanistic work shows it modulates GABAergic gene expression (Volkova et al., 2016). These are research findings - mostly from Russian clinical and animal studies - and are not a promise of any effect in humans.
How does Selank compare with benzodiazepines?
A Russian clinical study compared Selank directly with medazepam and found comparable anxiolytic effect. The reported difference is in the side-effect profile: review and clinical literature describe Selank as not producing sedation, amnesia, tolerance, dependence or withdrawal, which are common with benzodiazepines. It is studied as an allosteric GABAergic modulator rather than a direct GABA-A agonist.
How long does Selank take to work, and what is its half-life?
Plasma clearance is rapid - effectively complete within minutes of administration - but the Pro-Gly-Pro tail extends functional activity far beyond the parent tuftsin, whose half-life is measured in seconds. Russian clinical and review sources describe a fast onset for the anxiolytic effect via the intranasal route. We report these figures descriptively from the literature and make no dosing recommendation.
Is Selank legal, and is it FDA-approved?
Selank is not FDA-approved in the United States and is sold strictly as a research chemical for laboratory use, not for human consumption. It is a registered/approved anxiolytic medicine in Russia. Legal status varies by jurisdiction, so confirm your local rules before purchasing.
How does Selank compare with Semax?
Both are Russian heptapeptides with Pro-Gly-Pro stabilising tails and intranasal delivery, and they share several effects such as monoamine modulation. Selank emphasises anxiolysis and stress buffering; Semax (an ACTH(4-10) analogue) emphasises cognition and neuroprotection. They are sometimes studied together in protocols covering both the calm and the focus dimensions.
How should Selank be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The Pro-Gly-Pro tail gives Selank much better stability than parent tuftsin (which has a half-life measured in seconds), but standard peptide handling still applies - avoid repeated freeze-thaw cycles.
Where can I buy Selank?
Right here - Selank is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.
How much does Selank cost?
Selank pricing is shown live on this page, per pack size - 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $350.
Is Selank third-party tested?
Yes. Every Selank batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy Selank?
Add the Selank pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step. Every order ships with its batch Certificate of Analysis (COA).
What payment methods can I use to buy Selank?
At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes - we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.
Research use only - all claims made on this site are for testing and research use only.
Pharmacokinetics
Evidence Tier
Overall: Mixed (human + animal)
Evidence is predominantly Russian clinical and mechanistic work. Selank is a registered/approved anxiolytic medicine in Russia but is NOT FDA-approved and is not approved in the US or EU; the research-grade material supplied here is unapproved laboratory material.
Tier 1 · Human clinical
Tier 2 · Animal
Certificates, databases & peer-reviewed sources
Last reviewed: 16 June 2026 · New-U Research Compounds
Key Characteristics
Specifications
About Selank: Tuftsin-Derived Anxiolytic Nootropic Peptide Research Guide
Selank is the anxiolytic counterpart to Semax in the Russian heptapeptide family. Both peptides share the same structural trick - a Pro-Gly-Pro C-terminal tail that extends metabolic stability - but they start from different parent molecules. Selank builds on tuftsin, an immunomodulatory tetrapeptide naturally released during IgG heavy-chain processing, and is studied for a GABAergic, benzodiazepine-like anxiolytic profile without the sedation or dependence associated with classic benzodiazepines.
The most-cited Selank research is a Russian clinical study comparing it head-to-head with the benzodiazepine medazepam in anxiety disorders, where the anxiolytic effects were similar but Selank additionally showed antiasthenic and psychostimulant activity (Zozulya et al., 2008). On the mechanism side, Selank altered the expression of GABAergic-neurotransmission genes, supporting allosteric modulation of the GABAergic system as a likely pathway (Volkova et al., Frontiers in Pharmacology, 2016). The reported absence of sedation, tolerance and withdrawal is the research question that makes Selank interesting - though much of that profile comes from review and clinical literature rather than large independent trials.
New-U Research Compounds supplies Selank as a research-grade lyophilised powder at >99% HPLC purity, verified by independent third-party labs. All material is strictly for in-vitro and laboratory research use. Selank is not FDA-approved and is not approved for human therapeutic use in the United States; it is a registered anxiolytic medicine in Russia. Nothing on this page constitutes medical advice or a dose recommendation.
Customer Reviews
Good first order
First time ordering Selank from New-U Research Compounds. Checkout was simple, tracking updated properly and the vial arrived well packed.
- Khalid N*** · 30 August 2026
Clear Selank COA
The Selank COA was straightforward to check on the New-U site. Batch details matched the vial and the paperwork was easy to follow.
- Maya S**** · 30 August 2026
Selank from New-U
Bought Selank from New-U Research Compounds and the order arrived sealed, clean and clearly labelled. COA access was easy to find before checkout, which helped alot.
- Owen H****** · 30 June 2026
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