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Selank: Cognitive / Neuro research guide
Not medical advice. Selank is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.
What Selank is
Selank is a Russian anxiolytic heptapeptide derived from the immune peptide tuftsin that produces benzodiazepine-like calming effects through GABAA modulation - without sedation, amnesia, or dependence.
One-paragraph overview from our research datasheet — still scientific, but faster to read than the full mechanism list below.
Selank is a synthetic tuftsin-derived heptapeptide anxiolytic that allosterically modulates GABAA receptors and upregulates hippocampal BDNF expression.
Research contexts
Peer-reviewed literature typically discusses Selank in specific experimental settings. The points below reflect how the scientific community frames this compound—not as health claims, but as the research questions being asked.
Research vs. personal use: Literature describes experiments in controlled lab and animal models. This is distinct from any real-world use; our products are for laboratory research only.
Typical study contexts
Why Cognitive / Neuro research matters
Cognitive-related peptides are explored for stress-response pathways, neuronal signalling, and behaviour in animal models -not as treatments for human brain conditions.
Mechanisms (technical review)
Our datasheet lists mechanistic themes observed in preclinical work. These are research endpoints, not health claims. They help scientists understand and compare pathways.
Lab handling & preparation
Storage requirements: Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation. · Learn best practices in our detailed storage guide.
Research dosing context: Literature typically discusses 250–500 μg intranasal; 150–300 μg subcutaneous · Once daily intranasal (0.15% solution, 2–3 drops per nostril) · Complete plasma clearance within 10 minutes post-administration. C-terminal Pro-Gly-Pro extension substantially extends biological activity duration versus native tuftsin (t½ seconds). Intranasal route preferred for non-invasive CNS delivery. Metabolized rapidly in the liver and eliminated via renal excretion. Russian clinical doses: 150–300 μg intranasally, with anxiolytic effects observed within 10–15 minutes of administration.
Preparation steps: Follow our detailed reconstitution guide, use the calculator tool for volume confirmation, and always verify purity with the COA reading guide.
Common Questions People Are Asking
What is Selank and how does it work?
Selank is a synthetic seven-amino-acid (heptapeptide) derivative of the immune peptide tuftsin, with a Pro-Gly-Pro tail for stability, studied as an anxiolytic and nootropic research compound. The leading mechanistic hypothesis is allosteric modulation of the GABAergic system - it changes the expression of GABA-related genes rather than binding the GABA-A receptor as a direct agonist - alongside effects on monoamine neurotransmitters. New-U supplies it for laboratory research only.
What does the Selank research actually show?
The headline finding is a Russian clinical study where Selank produced anxiolytic effects similar to the benzodiazepine medazepam, plus additional antiasthenic (anti-fatigue) and psychostimulant activity (Zozulya et al., 2008). Mechanistic work shows it modulates GABAergic gene expression (Volkova et al., 2016). These are research findings - mostly from Russian clinical and animal studies - and are not a promise of any effect in humans.
How does Selank compare with benzodiazepines?
A Russian clinical study compared Selank directly with medazepam and found comparable anxiolytic effect. The reported difference is in the side-effect profile: review and clinical literature describe Selank as not producing sedation, amnesia, tolerance, dependence or withdrawal, which are common with benzodiazepines. It is studied as an allosteric GABAergic modulator rather than a direct GABA-A agonist.
How long does Selank take to work, and what is its half-life?
Plasma clearance is rapid - effectively complete within minutes of administration - but the Pro-Gly-Pro tail extends functional activity far beyond the parent tuftsin, whose half-life is measured in seconds. Russian clinical and review sources describe a fast onset for the anxiolytic effect via the intranasal route. We report these figures descriptively from the literature and make no dosing recommendation.
Is Selank legal, and is it FDA-approved?
Selank is not FDA-approved in the United States and is sold strictly as a research chemical for laboratory use, not for human consumption. It is a registered/approved anxiolytic medicine in Russia. Legal status varies by jurisdiction, so confirm your local rules before purchasing.
How does Selank compare with Semax?
Both are Russian heptapeptides with Pro-Gly-Pro stabilising tails and intranasal delivery, and they share several effects such as monoamine modulation. Selank emphasises anxiolysis and stress buffering; Semax (an ACTH(4-10) analogue) emphasises cognition and neuroprotection. They are sometimes studied together in protocols covering both the calm and the focus dimensions.
How should Selank be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The Pro-Gly-Pro tail gives Selank much better stability than parent tuftsin (which has a half-life measured in seconds), but standard peptide handling still applies - avoid repeated freeze-thaw cycles.
Is this page medical advice? Can I use Selank for my health?
No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.
Where do I find Selank specs, purity certificates and pricing?
Open the shop listing via “View product details.” There you will see batch specs, the Certificate of Analysis (COA), concentration, purity grade, and available SKUs with current pricing.
Related peptide guides
Other compounds researchers often read about alongside Selank.
Scientific sources & further reading
Primary literature and registries for Selank, plus mainstream coverage of the peptide category. Research use only - not medical advice.
Databases & literature:
Peptides in the news:
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Also known as: Selank, TP-7, Selanc, TKPRPGP, Tuftsin Analogue, Thr-Lys-Pro-Arg-Pro-Gly-Pro, Selank Acetate, PL14736
Premium research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical with a Certificate of Analysis on every lot. Shipped lab-direct, discreet and cold-chain, worldwide. For laboratory research use only.
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