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Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.
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Research use only (RUO). All products are sold strictly for laboratory and research purposes — not for human or veterinary consumption. Purchasers must be 21 or older.
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DSIP
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Lab-direct quality — full packs or single-vial samples
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity . Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a full sealed 10-vial research pack for a complete study supply, or add a single-vial sample alongside your pack to trial a new compound first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
In plain terms, DSIP is the original "sleep peptide" — found in the blood of sleeping animals and studied ever since. Here is what that looks like across the research.
Sleep architecture
Studied for its association with delta-wave (deep, slow-wave) sleep in EEG laboratory models — the phase of sleep it was originally isolated from.
Stress-axis research
Examined as a modulator of the hypothalamic-pituitary-adrenal axis, the system that governs cortisol and the stress response.
Withdrawal models
Used as a reference compound in animal research on opioid withdrawal and chronic pain states.
Neuropeptide comparisons
Pairs with Selank and Semax for comparative work on short regulatory neuropeptides that cross into the central nervous system.
Overview
In short: DSIP (Delta Sleep-Inducing Peptide) is a nine-amino-acid neuropeptide isolated from delta-wave sleep cerebral blood, studied for sleep architecture, stress-axis regulation, and neuroendocrine signalling.
Key research facts
Research use only. These points summarise lab themes, not human outcomes.
DSIP has one of the more memorable origin stories in peptide science. In 1977, Schoenenberger and Monnier at the University of Bern held rabbits in electrically induced delta-wave sleep and isolated a nine-residue peptide from their cerebral venous blood. Transferred to other animals, the fraction appeared to promote the same slow-wave sleep pattern — hence the name.
Nearly fifty years later, the peptide remains a genuine open question. No DSIP receptor has ever been cloned, its endogenous concentrations are low and variable, and replication across laboratories has been mixed. What the literature does document is a broad set of effects in animal and cell-culture models: influence on delta-wave EEG patterns, modulation of corticotropin and somatotropin release, activity in opioid-withdrawal and chronic-pain models, and antioxidant behaviour. That combination — a well-defined, easily synthesised sequence attached to an unresolved mechanism — is what keeps it in circulation as a laboratory reference compound.
DSIP (under the name Emideltide) was one of the peptides discussed by the FDA Pharmacy Compounding Advisory Committee in July 2026 regarding the 503A Bulks List. A compounding review is not an approval and not a clinical endorsement. DSIP is supplied here as a research-grade lyophilised powder for in-vitro and preclinical work only, and nothing on this page is medical advice.
Mechanism of Action
DSIP is studied as a diffuse neuromodulator rather than a classical receptor agonist: no dedicated receptor has been identified, and its documented effects on sleep EEG, the HPA axis and pituitary hormone release are best framed as observed associations in animal models rather than an established signalling pathway.
The pharmacology of DSIP is unusual in that the peptide is well characterised chemically but poorly characterised mechanistically. It is a small, hydrophilic nonapeptide (MW 848.81 Da) with a reported plasma half-life in the order of minutes, yet effects in animal models are described over far longer windows — a discrepancy the literature has not resolved, and one hypothesis is that DSIP acts through downstream cascades or metabolite fragments rather than direct sustained occupancy. No dedicated DSIP receptor has been cloned despite decades of searching, and endogenous plasma concentrations are low and variable. Controlled human efficacy data are sparse and largely historical. For research purposes DSIP is best treated as a well-defined chemical probe attached to an unsettled biological question, not as a validated pharmacological agent.
Common Questions People Are Asking
What is DSIP used for in research?
DSIP is studied as a research tool in sleep architecture, stress-axis (HPA) regulation and neuroendocrine signalling. Published work spans delta-wave EEG effects, corticotropin and somatotropin release, opioid-withdrawal and chronic-pain models, and antioxidant activity — almost all in animal or cell-culture systems. It is supplied here for laboratory research only and is not for human use.
Why is it called "Delta Sleep-Inducing Peptide"?
The name comes from its 1977 isolation: Schoenenberger and Monnier held rabbits in electrically induced delta-wave (deep, slow-wave) sleep and isolated a nine-residue peptide from their cerebral venous blood. Transferred to other animals, the fraction appeared to promote the same slow-wave pattern. The name records that founding observation rather than a proven mechanism.
How is DSIP proposed to work?
That remains genuinely unresolved. No dedicated DSIP receptor has ever been cloned, so the peptide is studied as a diffuse neuromodulator rather than a classical receptor agonist. Its documented effects on sleep EEG, the HPA axis and pituitary hormone release are best described as observed associations in animal models. One open puzzle is that its reported plasma half-life is only minutes while observed effects span far longer windows.
What is Emideltide, and did the FDA approve DSIP?
Emideltide is the designation used for DSIP in regulatory and compounding contexts. In July 2026 it was among the peptides reviewed by the FDA Pharmacy Compounding Advisory Committee for potential 503A Bulks List inclusion. That is a compounding-eligibility review — not a marketing approval, not a safety determination and not a clinical endorsement. DSIP remains an unapproved research compound.
How should DSIP be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water or sterile saline, refrigerate at 1–6 °C and protect from light. As a small hydrophilic nonapeptide it tolerates standard peptide-handling conditions well within the normal usage window.
Where can I buy DSIP?
Right here — DSIP is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging. Strictly for laboratory research use only — not for human use.
How much does DSIP cost?
DSIP pricing is shown live on this page, per pack size — 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $300.
Is DSIP third-party tested?
Yes. Every DSIP batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy DSIP?
Add the DSIP pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). DSIP is supplied strictly for laboratory research use only, not for human or veterinary use.
What payment methods can I use to buy DSIP?
At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.
Is it legal to buy DSIP?
In the United States, DSIP is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction — buyers are responsible for compliance in their own region.
Pharmacokinetics
Evidence Tier
Overall: Tier 3: Anecdotal / self-report
DSIP has a long but thin evidence base: the founding isolation work dates to 1977 and a scattered animal and cell-culture literature has accumulated since, but no dedicated receptor has been identified, replication across laboratories has been inconsistent, and controlled human pharmacokinetic and efficacy data are sparse and largely historical. It has no Western regulatory approval — its July 2026 FDA compounding-committee review concerned 503A Bulks List eligibility, which is neither an approval nor a clinical endorsement — and it is supplied as unapproved laboratory material.
Source References & Further Reading
Last reviewed: 29 July 2026 · New-U Research Compounds
Key Characteristics
Specifications
About DSIP (Delta Sleep-Inducing Peptide): Sleep and Stress-Axis Research Guide
DSIP occupies a peculiar position in neuroscience: a peptide everyone has heard of, isolated from an elegant experiment, whose mechanism has resisted explanation for nearly fifty years. Schoenenberger and Monnier's 1977 work at Bern — inducing delta-wave sleep in rabbits electrically, then isolating a nine-residue fraction from cerebral venous blood that appeared to transfer the effect — was a landmark for the "endogenous sleep substance" hypothesis. The peptide it produced has been synthesised, sequenced and studied continuously since.
What the literature has not produced is a receptor. Despite decades of searching, no dedicated DSIP binding site has been cloned, and endogenous concentrations are low and variable enough that even its physiological role is debated. Documented effects in animal and cell-culture models are broad rather than deep: delta-wave EEG associations, modulation of corticotropin and somatotropin release, activity in opioid-withdrawal and chronic-pain models, and antioxidant behaviour in rodent tissue. Replication across laboratories has been inconsistent. The short reported plasma half-life sits awkwardly against the longer observed effect windows, and that gap remains unexplained.
In July 2026 DSIP — as Emideltide — was among the peptides reviewed by the FDA's Pharmacy Compounding Advisory Committee for potential 503A Bulks List inclusion. That is a compounding-eligibility discussion, not a marketing approval, not a safety determination, and not a clinical endorsement. New-U Research Compounds supplies DSIP as a research-grade lyophilised powder at >99% HPLC purity. All material is strictly for in-vitro and preclinical research use. DSIP is not approved for human therapeutic use in any major jurisdiction, and nothing on this page constitutes medical advice or a dosing recommendation.
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