Buy PE 22-28 Spadin-Derived Research Peptide

Every batch ships straight from the lab that synthesises it — sealed, tamper-evident. Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.

Order a sealed 10-vial research pack , or add a single-vial laboratory sample alongside your pack to evaluate a compound at smaller scale first. Same source — scaled to whatever your research needs.

Scientific Research Context

What the published literature on PE 22-28 and its parent peptide spadin examined in cells and rodents. Findings about the compound in these studies are not claims about the supplied material.

TREK-1 current inhibition in cells

In a human TREK-1 HEK cell line, PE 22-28 inhibited the channel current by about 55% at 100 nM against about 44% for spadin. The reported IC50 was about 0.12 nM for PE 22-28 and about 40 nM for spadin. [in vitro]

Persistence in serum and in mice

The 2017 paper reported that the action of PE 22-28 and its analogues lasted up to about 23 hours in mice, compared with roughly 6 to 7 hours for spadin, and followed degradation of spadin in mouse serum. [animal]

Rodent behavioural models

In male C57Bl/6J mice, the authors reported shorter immobility in the forced swim test, shorter feeding latency in the novelty suppressed feeding test and shorter escape latency in a learned helplessness test after treatment with the peptides. Hippocampal BrdU labelling was also measured. These are mouse test readouts, not human outcomes. [animal]

Parent peptide spadin

The 2010 PLoS Biology paper described spadin, a sortilin-derived peptide, as targeting rodent TREK-1 channels and reported TREK-1-related behavioural readouts in mice. PE 22-28 was derived from it. [animal]

Overview

In short: PE 22-28 is a seven-residue peptide cut down from spadin, the sortilin-propeptide fragment studied as a TREK-1 potassium channel blocker in rodent research.

Key research facts

Seven-residue fragment (propeptide positions 22-28) derived from spadin, PE 12-28

Characterised by patch-clamp on a human TREK-1 HEK cell line, with a reported IC50 near 0.1 nM against about 40 nM for spadin

Compared with spadin for persistence in mouse serum and in mice

Reference peptide for TREK-1 (K2P) channel pharmacology in rodent behavioural-model research

Single 10 mg strength; sealed 10-vial pack or one-vial sample

These points summarise lab themes, not human outcomes.

The name refers to positions 22 to 28 of the sortilin propeptide (PE). Spadin spans positions 12 to 28, so PE 22-28 keeps the C-terminal end and drops the first ten residues. The group behind it, Djillani, Pietri, Moreno, Heurteaux, Mazella and Borsotto, reported that the shorter peptide inhibited TREK-1 more potently than spadin in cell recordings.

The record is small and preclinical: patch-clamp work on a HEK cell line, serum-stability work, and a set of mouse behavioural tests, almost all from one research group. No controlled human data are cited on this page, and the mouse results are not claims about people or about the supplied material.

Residue-level sequence, molecular formula and molecular weight are not stated on this page because they could not be confirmed from the cited papers. No analytical report for the supplied material has been published yet, so no purity figure is quoted.

Research class: Spadin-derived peptide; TREK-1 (K2P) channel blocker in rodent research

Length: Seven residues (propeptide positions 22-28)

Evidence base: Cell recordings and mouse studies; no controlled human data cited

Channel Pharmacology

PE 22-28 is studied as an inhibitor of TREK-1, a two-pore-domain potassium (K2P) channel. The mechanism is described from cell electrophysiology and mouse behavioural tests only.

Pathway Effect Why it matters TREK-1 current inhibition Reduced human TREK-1 current in HEK cells, with a reported IC50 near 0.1 nM The defining measurement for the peptide, made in a cell line Relation to spadin Derived from spadin (PE 12-28), which was reported to target rodent TREK-1 Places the peptide in the spadin series studied by the same group Persistence Reported action of up to about 23 hours in mice against about 6 to 7 hours for spadin The main reason the shorter peptide was characterised Behavioural readouts Forced swim, novelty suppressed feeding and learned helplessness results in mice Rodent test readouts; they do not establish effects in humans

Deeper dive for scientific readers

The 2010 work proposed spadin as a modulator of TREK-1 in rodents, and the 2017 work asked whether a shorter fragment could keep that activity while lasting longer after administration. This page describes cellular and rodent findings only and draws no conclusion about use in people.

Common Questions People Are Asking

What is PE 22-28?

PE 22-28 is a seven-residue peptide derived from spadin, covering positions 22 to 28 of the sortilin propeptide. It was studied as a TREK-1 channel inhibitor in cells and mice. This page supplies it as laboratory research material only.

How does it differ from spadin?

Spadin spans positions 12 to 28 of the propeptide; PE 22-28 is the shorter seven-residue fragment. In the 2017 paper it inhibited TREK-1 currents at a lower concentration than spadin and its action was reported to last longer in mice.

Is there human research on PE 22-28?

No controlled human data are cited on this page. The studies cited used a human TREK-1 cell line and mice, and their results do not establish effects in people.

Why is the sequence not listed?

The residue letters, formula and molecular weight could not be confirmed from the cited papers, so they are left out rather than guessed.

Is there a Certificate of Analysis for PE 22-28?

Not yet. No independent analytical report has been published for this material, so no purity figure is quoted.

What does the single-vial sample contain?

One 10 mg vial of the same lyophilised research material as the sealed 10-vial pack, for in-vitro and preclinical use only.

Where can I buy PE 22-28?

Right here - PE 22-28 is supplied directly by New-U Research Compounds on this page, as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.

How much does PE 22-28 cost?

PE 22-28 pricing is shown live on this page, per pack size - 10-vial research packs as standard, with single-vial sample options on selected compounds. Shipping is free on orders over $350.

How do I buy PE 22-28?

Add the PE 22-28 pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step.

What payment methods can I use to buy PE 22-28?

At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.

How fast is shipping, and do you ship worldwide?

Yes - we ship worldwide in discreet, unmarked, tracked packaging; lyophilised peptides are stable through the tracked transit window. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.

Is it legal to buy PE 22-28?

In the United States, PE 22-28 is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction - buyers are responsible for compliance in their own region.

Research use only - all claims made on this site are for testing and research use only.

Pharmacokinetics

Stability Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Notes Laboratory research material. No amount, schedule or administration guidance is published or recommended on this page.

Evidence Tier

Overall: Tier 3: Limited / anecdotal

The tier describes the published literature, not the supplied material. The record consists of cell recordings and mouse studies from one research group, with no controlled human data cited. No analytical report for the supplied material has been published yet.

Databases & peer-reviewed sources

Last reviewed: 13 October 2026 · New-U Research Compounds

Djillani A, Pietri M, Moreno S, Heurteaux C, Mazella J, Borsotto M. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity. Front Pharmacol 2017. · 2017 · PMID: 28955242 · DOI: 10.3389/fphar.2017.00643

Mazella J, Pétrault O, Lucas G, et al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol 2010. · 2010 · PMID: 20405001 · DOI: 10.1371/journal.pbio.1000355

PubMed: peer-reviewed literature on PE 22-28

ClinicalTrials.gov: registered studies on PE 22-28

PE 22-28: Wikipedia (search)

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Key Characteristics

Seven-residue peptide derived from spadin (sortilin propeptide positions 22-28)

Studied as a TREK-1 (K2P) channel inhibitor in cells and mice

Evidence is preclinical and from one research group; no controlled human data cited

No amount, schedule or administration guidance on this page

Supplied as 10 mg vials: sealed 10-vial pack or single-vial sample; no analytical report published yet

Specifications

Length 7 residues (propeptide positions 22-28) Parent peptide Spadin (PE 12-28) Supplier code Y-53 Form Lyophilised powder Strength 10 mg per vial Pack 10 vials, or a single-vial sample Analytical report None published yet Storage Lyophilised: −20 °C freezer. Reconstituted: 1-6 °C, away from light.

About PE 22-28: Spadin-Derived TREK-1 Research Guide

PE 22-28 came out of work on spadin, a fragment of the sortilin propeptide that the Mazella and Heurteaux laboratories described in 2010 as acting on rodent TREK-1 channels. The 2017 Frontiers in Pharmacology paper shortened it to seven residues and compared the new peptides with spadin in cell recordings, serum stability and mouse tests.

Every result cited here comes from cultured cells or mice. No controlled human data are cited, and the mouse findings do not establish effects, safety or intended use in people or for the research material New-U supplies.

New-U Research Compounds supplies PE 22-28 as a lyophilised research powder in 10 mg vials, as a sealed 10-vial pack or a single-vial sample. No analytical report for the supplied material has been published yet, so this page makes no purity or certificate claim. It is for in-vitro and preclinical research only, is not a medicine, and nothing here is medical advice.

Djillani et al., Front Pharmacol 2017 (PubMed 28955242)

Mazella et al., PLoS Biol 2010 (PubMed 20405001)

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Descriptive catalog comparison for research sourcing decisions - not dosing guidance.

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PE 22-28 research guide

Research this compound

Research guide PE 22-28 research guide PE 22-28 is studied as an inhibitor of TREK-1, a two-pore-domain potassium (K2P) channel. Read the guide →

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Research peptides. Third-party Certificates of Analysis (Janoshik Analytical & Freedom Diagnostics) are published on the website. Supplied strictly for laboratory research use.

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