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Cardiogen peptide: Metabolic / Longevity research guide

In short: Cardiogen (Ala-Glu-Asp-Arg / AEDR) is a synthetic tetrapeptide from the Khavinson short-peptide family, studied for cytoskeletal protein expression and for growth of myocardial tissue explants. It is studied in preclinical (cell and animal) research and is supplied strictly for laboratory use, not for human or clinical use.

Not medical advice. Cardiogen is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.

Cardiogen at a glance

Compound type

Research peptide

Research category

Metabolic / Longevity

Also known as

Cardiogen, AEDR, Ala-Glu-Asp-Arg, H-Ala-Glu-Asp-Arg-OH, alanyl-glutamyl-aspartyl-arginine, Khavinson cardiac bioregulator

Molecular weight

489.49 Da

Evidence context

Preclinical / research use only

Regulatory status

Not an approved medicine. Supplied as a research compound

Last reviewed

13 October 2026

What to know first

Compound Cardiogen Research class Metabolic / Longevity Available pack sizes 10 × 20 mg Storage Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight.

Details and limits sit in the sections below. Research use only. No unsupported scientific claims are added here.

What Cardiogen is

Cardiogen (Ala-Glu-Asp-Arg, "AEDR") is a four-residue synthetic peptide from the Khavinson bioregulator family, studied for cytoskeletal gene expression in cultured cells and growth of heart-tissue explants.

One-paragraph overview from our research datasheet. Still scientific, but faster to read than the full mechanism list below.

Cardiogen (Ala-Glu-Asp-Arg / AEDR) is a synthetic tetrapeptide from the Khavinson short-peptide family, studied for cytoskeletal protein expression and for growth of myocardial tissue explants.

Research contexts

Peer-reviewed papers discuss Cardiogen in specific lab settings. The points below reflect research questions, not health claims.

Research vs. personal use: Literature describes experiments in cells and animals. That is distinct from real-world use. Our products are for laboratory research only.

Typical study contexts

Mitochondrial stress, NAD+/redox biology and nutrient-sensing pathways.

Enzyme activity, gene expression or endurance-style animal readouts.

Synthetic Ala-Glu-Asp-Arg (AEDR) tetrapeptide from the Khavinson short-peptide lineage.

Studied for expression of actin, tubulin, vimentin and nuclear lamins in cultured fibroblasts.

Examined in organotypic myocardial explants from young and old rats.

Tested alongside Bronchogen, Prostamax and Pancragen for tissue-matched explant growth.

Why Metabolic / Longevity research matters

Researchers study these compounds for mitochondrial function and cellular energy stress. Ageing and metabolic disease models are common.

Mechanisms (technical review)

Our datasheet lists mechanistic themes from preclinical work. These are research endpoints, not health claims.

Synthetic Ala-Glu-Asp-Arg (AEDR) tetrapeptide from the Khavinson short-peptide lineage

Studied for expression of actin, tubulin, vimentin and nuclear lamins in cultured fibroblasts

Examined in organotypic myocardial explants from young and old rats

Tested alongside Bronchogen, Prostamax and Pancragen for tissue-matched explant growth

Shares the Ala-Glu-Asp stem with Cartalax and Epitalon

Lab handling & preparation

Storage: Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight.. See the storage guide.

Published pharmacokinetic context: Laboratory research material. No human dosing exists for this compound and none is published or recommended here.

Purity check: Use the COA reading guide and the published Certificates of Analysis (no current certificate is listed for Cardiogen yet).

Common Questions People Are Asking

What is Cardiogen?

Cardiogen is the name used for the synthetic tetrapeptide Ala-Glu-Asp-Arg (AEDR) from the Khavinson short-peptide programme, which pairs it with heart tissue. It is supplied here as a laboratory research powder only.

What does the research on Cardiogen show?

In cultured mouse fibroblasts it was reported to raise actin, tubulin, vimentin and lamin expression. In rat tissue explants it stimulated growth of heart tissue, and in a four-tissue comparison it stimulated heart tissue only. All of it is preclinical and the peptide-specific papers are mostly from one research network.

Why is Cardiogen hard to look up?

The name collides with other products. A chemical-database search for "cardiogen" returns carnitine, and most PubMed hits are about a rubidium-82 generator. Look it up by sequence (Ala-Glu-Asp-Arg) instead.

Is there a Certificate of Analysis for Cardiogen?

Not yet. No independent analytical report has been published for this material, so no purity figure is quoted.

Is there human data on Cardiogen?

No human study was found in the literature cited here. Cardiogen is sold strictly for in-vitro and preclinical research, not for human or veterinary use.

Is this page medical advice? Can I use Cardiogen for my health?

No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.

Where do I find Cardiogen specs, purity certificates and pricing?

Open the shop listing via “View product details.” There you will see concentration, purity grade, and available SKUs with current pricing. No current Certificate of Analysis is published for Cardiogen yet; published certificates are listed at /coa.

Related peptide guides

Other compounds researchers often read about alongside Cardiogen.

Cartalax: Metabolic / Longevity research guide

Epitalon: Metabolic / Longevity research guide

Pinealon: Metabolic / Longevity research guide

Bronchogen: Metabolic / Longevity research guide

Continue Cardiogen research

Analytical evidence, comparisons and current research for this compound. Research use only.

Research area Cognitive & longevity research The neuropeptide and longevity research area - nootropic and geroprotective peptides and related compounds studied in cognition… Explore the research area →

Scientific sources & further reading

Primary literature and registries for Cardiogen, plus mainstream coverage of the peptide category. Research use only - not medical advice.

Databases & literature:

PubMed: peer-reviewed literature on Cardiogen

ClinicalTrials.gov: registered studies on Cardiogen

Cardiogen: Wikipedia (search)

Peptides in the news:

WebMD: consumer health reference

BBC News: Health

CNN Health: “Peptides: what to know about the wellness trend”

Sky News: “Can peptides make America healthy again?”

Sky News: “Inside the exploding US peptides craze” (video)

Sky News Australia: “Black market peptide trade explodes as influencers fuel uptick in use”

Sky News Australia: “Backyard peptide boom sparks alarm” (video)

Sky News Australia: “Oprah reveals struggle with shame of weight-loss drugs”

Ready to order? View full product specs

Access concentration, batch info, variants, and current pricing on our shop.

Also known as: Cardiogen, AEDR, Ala-Glu-Asp-Arg, H-Ala-Glu-Asp-Arg-OH, alanyl-glutamyl-aspartyl-arginine, Khavinson cardiac bioregulator

PRECISION. PURITY. PERFORMANCE.

Research peptides. Third-party Certificates of Analysis (Janoshik Analytical & Freedom Diagnostics) are published on the website. Supplied strictly for laboratory research use.

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