Shop by goal
Popular compounds
Research resources
Recently viewed
Premium research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical with a Certificate of Analysis on every lot. Shipped lab-direct, discreet and cold-chain, worldwide. For laboratory research use only.
Shop
Learn
Company
Support
Ways to Pay
Shop by Compound
Shop by Goal
Ships worldwide
Research use only (RUO). All products are sold strictly for laboratory and research purposes — not for human or veterinary consumption. Purchasers must be 21 or older.
All rights reserved. Copyright of New-U held with Hilxera Distribution Services LLC 2026.
Website & business operated by Hilxera Distribution Services LLC. Registered in Wyoming, ID: 2026-001928701.
© 2026 New-U Research Compounds · new-u.io · @new.u.io
Kisspeptin
Pick your pack · how long it lasts
At 0.700 mg/wk — select pack size
1 × 10-vial pack required for packing — samples add on to any pack
Lab-direct quality — full packs or single-vial samples
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a batch-linked Certificate of Analysis. Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a full sealed 10-vial research pack for a complete study supply, or add a single-vial sample alongside your pack to trial a new compound first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
In plain terms, Kisspeptin is studied mainly as a hormone and fertility signalling compound. Here is what that looks like across the research.
Hormone & fertility signalling
Studied as the master upstream switch of the reproductive hormone system, sitting one step above the signals that drive the testes and ovaries.
Reproductive hormone release
In clinical research, human physiology studies show it raises the key gonadotropin hormones LH and FSH that govern fertility.
Puberty & reproductive research
A central tool for studying how puberty begins and how the brain controls the menstrual cycle and fertility.
Natural axis probe
Research explores it as a gentler, more physiological way to study the reproductive axis than older direct-acting agents.
Overview
Kisspeptin-10 is the ten-amino-acid business end of the KISS1 gene product — the single most potent natural trigger of the reproductive hormone axis, acting one step upstream of GnRH itself.
Kisspeptin is the neuropeptide encoded by the KISS1 gene. The full-length product (kisspeptin-54, also called metastin) is cleaved into shorter fragments — kisspeptin-14, -13 and -10 — that all share the same C-terminal decapeptide responsible for receptor binding. Kisspeptin-10 (KP-10) is that minimal active fragment.
Its receptor, KISS1R (originally named GPR54), sits on GnRH neurons in the hypothalamus. When kisspeptin binds, those neurons fire and release gonadotropin-releasing hormone, which drives the pituitary to secrete LH and FSH, which in turn drive the gonads. That places kisspeptin at the very top of the hypothalamic-pituitary-gonadal axis — the upstream switch the rest of the cascade depends on.
The discovery that humans lacking a working KISS1R fail to enter puberty turned kisspeptin into one of the most-studied molecules in reproductive endocrinology. Supplied here as sterile lyophilised powder for research use only.
Mechanism of Action
Kisspeptin binds KISS1R (GPR54) on GnRH neurons, triggering GnRH release that cascades down to LH, FSH and gonadal sex steroids — the master upstream control point of the reproductive axis.
de Roux et al. (PNAS, 2003) and Seminara et al. (New England Journal of Medicine, 2003) independently showed that inactivating mutations in KISS1R/GPR54 cause idiopathic hypogonadotropic hypogonadism — patients fail to enter puberty despite an intact GnRH system — establishing kisspeptin-KISS1R signalling as an obligatory upstream gate of the reproductive axis. Subsequent human physiology work (e.g. Dhillo et al., Imperial College London) demonstrated that exogenous kisspeptin administration raises circulating LH and FSH, motivating its study as a more physiological way to interrogate the axis than direct GnRH agonism.
Common Questions People Are Asking
What is kisspeptin and how does it work?
Kisspeptin-10 is the active C-terminal decapeptide of the KISS1 gene product (metastin). It works by binding KISS1R (GPR54), a Gq/11-coupled receptor on hypothalamic GnRH neurons, triggering phospholipase-C signalling and a calcium rise that makes those neurons fire and release GnRH. That GnRH pulse then drives pituitary LH and FSH secretion, placing kisspeptin at the very top of the reproductive hormone cascade.
How is kisspeptin different from a GnRH agonist?
A GnRH agonist acts directly on the pituitary side of the cascade. Kisspeptin acts one step earlier, on the GnRH neurons in the hypothalamus that release GnRH in the first place. That upstream position is why researchers use it to study the natural, physiological control of the reproductive axis rather than overriding it.
What does the human research actually show?
Controlled human physiology studies report that exogenous kisspeptin raises circulating LH (mean increase ~2.75 IU/L in one trial) and, more modestly, FSH, without altering downstream estradiol, progesterone or testosterone over short study windows. Randomised clinical trials in men and women with hypoactive sexual desire disorder also found that kisspeptin modulated activity in sexual-processing brain networks. These are published research findings, not human-use claims — kisspeptin is supplied for laboratory research only.
What is the difference between kisspeptin-10 and kisspeptin-54?
Kisspeptin-54 (metastin) is the full-length peptide; kisspeptin-10 is its C-terminal ten-amino-acid fragment. Both bind the same KISS1R receptor through the shared C-terminal sequence. Kisspeptin-10 is shorter and shorter-acting (a circulating half-life on the order of minutes), while kisspeptin-54 circulates longer, which is why studies pick one or the other depending on whether they need a brief pulse or sustained exposure.
Why is kisspeptin also called metastin?
The KISS1 gene was originally discovered as a metastasis-suppressor gene, and its product was named metastin before the reproductive role of its receptor (GPR54/KISS1R) was understood. Kisspeptin and metastin refer to the same molecule.
How does kisspeptin compare with hCG as a reproductive-axis tool?
They act at opposite ends of the same axis. Kisspeptin acts at the top, on hypothalamic GnRH neurons, recruiting the body's own LH/FSH release in a physiological way. hCG acts at the bottom, directly on the gonad via the LH/CG receptor, mimicking the LH surge. Researchers choose kisspeptin to study upstream, natural control and hCG to drive direct gonadal stimulation.
How should kisspeptin be stored and handled?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1–6 °C and protect from light. As with most research peptides, avoid repeated freeze-thaw cycles of the reconstituted solution. This is laboratory handling guidance only.
Where can I buy Kisspeptin?
Right here — Kisspeptin is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging. Strictly for laboratory research use only — not for human use.
How much does Kisspeptin cost?
Kisspeptin pricing is shown live on this page, per pack size — 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $300.
Is Kisspeptin third-party tested?
Yes. Every Kisspeptin batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy Kisspeptin?
Add the Kisspeptin pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). Kisspeptin is supplied strictly for laboratory research use only, not for human or veterinary use.
What payment methods can I use to buy Kisspeptin?
At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.
Is it legal to buy Kisspeptin?
In the United States, Kisspeptin is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction — buyers are responsible for compliance in their own region.
Pharmacokinetics
Published Research Context
Kisspeptin is studied across a wide range of doses and routes that depend entirely on the experimental model. Because it is supplied strictly for research, no human dose or protocol is provided.
Evidence Tier
Overall: Mixed (human + animal)
Kisspeptin has genuine human data — a randomised clinical trial plus human genetic and neuroendocrine challenge studies of the reproductive axis — but no approved indication in any jurisdiction, so the evidence spans clinical-grade endpoints and mechanistic research. Supplied here as unapproved laboratory material for research use only.
Tier 1 · Human clinical
Source References & Further Reading
Last reviewed: 16 June 2026 · New-U Research Compounds
Key Characteristics
Specifications
About Kisspeptin-10 (KP-10 / Metastin): KISS1R / GPR54 Agonist and Master Regulator of the Reproductive Axis
Kisspeptin occupies a unique position in reproductive biology: it is the upstream signal that switches on the entire hypothalamic-pituitary-gonadal (HPG) axis. Where GnRH agonists act on the pituitary cascade directly, kisspeptin acts one level higher, on the GnRH neurons themselves, which makes it a powerful tool for studying how the body naturally regulates fertility, puberty, and the menstrual cycle.
The molecule was first described as a metastasis suppressor (metastin) before its KISS1R/GPR54 receptor was deorphanised and linked to puberty. The landmark finding — that people with inactivating GPR54 mutations never enter puberty — showed that kisspeptin signalling is not merely modulatory but obligatory for normal reproductive development. Human physiology studies (Dhillo group, Imperial College London) have since shown that exogenous kisspeptin raises circulating LH and FSH, and more recent randomised trials have extended the research into sexual-brain-processing pathways.
New-U Research Compounds supplies kisspeptin-10 as a lyophilised powder at >99% HPLC purity, verified by independent third-party labs. All material is strictly for in-vitro and preclinical research. Kisspeptin is not approved for human therapeutic use, and nothing on this page is medical advice.
Customer Reviews
No customer reviews yet — be the first to share your experience.
More in Hormone / Fertility
Kisspeptin vs related Hormone / Fertility compounds
Descriptive catalog comparison for research sourcing decisions — not dosing guidance. All compounds are for laboratory research use only.