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HCG
HCG glycoprotein hormone (α/β heterodimer, 37.9 kDa) activates LHCGR receptor via PKA/PKC/Smad2 cascades for gonadal steroidogenesis and fertility support.
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PRECISION. PURITY. PERFORMANCE.
Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.
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Research use only - all claims made on this site are for testing and research use only. Purchasers must be 21 years of age or older.
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© 2026 New-U Research Compounds · new-u.io
HCG
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Buy the 10-pack - save 67%/IU
Buy the 10-pack - save 67%/IU
Buy the 10-pack - save 67%/IU
Single vials ship as an add-on to a 10-vial pack - browse 10-vial packs
Lab-direct quality — full packs or single-vial samples
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity . Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a sealed 10-vial research pack , or add a single-vial laboratory sample alongside your pack to evaluate a compound at smaller scale first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
In plain terms, hCG is a hormone compound studied mainly for fertility and for supporting natural testosterone production. Here is what that looks like across the research.
Testosterone support
Studied as a stand-in for the natural signal that tells the testes to make testosterone, of interest in low-testosterone research.
Fertility & IVF research
In clinical research, used to trigger final egg maturation, the step that underlies IVF and assisted-fertility protocols.
Early-pregnancy support
Reproductive studies investigate how it helps maintain the hormone environment needed in the first weeks of pregnancy.
Hormone & receptor research
A long-established laboratory tool for studying how the LH/CG receptor and gonadal hormone signalling work.
Pregnancy-test biology
Because it is cleared into urine in early pregnancy, it is the molecule that home pregnancy tests are built to detect.
Overview
In short: Human chorionic gonadotropin (hCG) is a 237-amino-acid heterodimeric glycoprotein that activates the LH/CG receptor, used in published research as a luteinizing hormone surrogate for gonadal steroidogenesis and fertility studies.
Key research facts
These points summarise lab themes, not human outcomes.
hCG is one of the oldest peptide hormones used in endocrinology research. It is produced naturally by the placenta during pregnancy and is structurally homologous to luteinizing hormone (LH), with which it shares the same alpha subunit. The unique beta subunit gives hCG a longer circulating half-life and slightly different receptor kinetics than LH.
In research it functions as an LH surrogate at the LH/CG receptor (LHCGR). On Leydig cells it drives testosterone biosynthesis; on ovarian granulosa cells it triggers oocyte maturation and the LH surge used in IVF protocols. It is also the basis of urine pregnancy tests, since circulating hCG is renally cleared into urine in nanogram quantities during early pregnancy.
Supplied here as sterile lyophilised glycoprotein for in-vitro and preclinical research. It is not a licensed pharmaceutical product. Activity is reported in IU rather than mg because, like all gonadotropins, hCG is dosed against an international biological potency standard rather than by mass.
Mechanism of Action
hCG binds the LH/CG receptor (LHCGR) on gonadal tissue, activating PKA, PKC, and Smad2 cascades that drive steroid hormone production in Leydig cells and oocyte maturation in granulosa cells.
hCG pharmacokinetics (Trinchard-Lugan et al., British Journal of Clinical Pharmacology, 2021) show apparent clearance of ~0.5 L/h, terminal half-life of ~45 hours (substantially longer than native LH), and dose-proportional AUC and Cmax following single and multiple SC doses. Cole (Reproductive Biology and Endocrinology, 2010) reviewed the structural biology: 237 amino acids total (92 + 145), ~37.9 kDa, with eight carbohydrate chains comprising ~30% of molecular weight. Renal clearance is the basis of urinary hCG detection in pregnancy tests.
Common Questions People Are Asking
What is hCG and how does it work?
Human chorionic gonadotropin is a heterodimeric glycoprotein hormone produced by the placenta. It works by binding the LH/CG receptor (LHCGR) shared with luteinizing hormone, switching on the PKA/PKC steroidogenic cascade. On Leydig cells that drives testosterone biosynthesis; on ovarian granulosa cells it triggers final oocyte maturation, which is why it functions as an LH surrogate in reproductive research.
Why is hCG dosed in IU rather than mg?
Like all gonadotropins, hCG is calibrated against an international biological potency standard rather than by mass, because glycosylation pattern can change the mass-to-bioactivity ratio. One IU corresponds to approximately 1.68 μg of pure peptide. Published research protocols preserve the IU convention because it tracks biological activity directly rather than weight.
How is hCG different from luteinizing hormone (LH)?
hCG and LH share the same alpha subunit and act on the same receptor (LHCGR). The unique, heavily glycosylated beta-subunit tail gives hCG a much longer circulating half-life - on the order of ~24–36 hours versus roughly 30 minutes for LH - which is why hCG is the preferred research tool for sustained receptor activation. In Leydig-cell studies, plasma testosterone rises within an hour of an hCG bolus even though receptor binding sites subsequently down-regulate.
What does the research literature describe for hCG half-life and Leydig-cell response?
Pharmacokinetic work reports a terminal half-life substantially longer than LH, with apparent clearance around 0.5 L/h after subcutaneous administration. In Leydig-cell physiology studies, a single hCG injection produces a rapid plasma testosterone rise within the first hours, followed by receptor down-regulation over the following days. These are descriptive published-research findings, not a protocol - hCG is supplied for laboratory research only.
How is hCG used in IVF and fertility research?
In assisted-reproduction research hCG is used as the "trigger" that mimics the natural mid-cycle LH surge, prompting final oocyte maturation before egg retrieval. In male reproductive models it is studied as an LH stand-in to drive endogenous testosterone production. Both uses exploit the same LHCGR agonism; New-U supplies hCG strictly for in-vitro and preclinical research, not for human fertility use.
How does hCG compare with kisspeptin as a reproductive-axis tool?
They act at opposite ends of the same axis. hCG acts at the bottom, directly on the gonad via the LH/CG receptor, mimicking the LH surge. Kisspeptin acts at the very top, on hypothalamic GnRH neurons, switching on the whole cascade more physiologically. Researchers pick hCG when they want direct gonadal stimulation and kisspeptin when they want to study upstream, natural control of LH/FSH release.
How should hCG be stored and reconstituted?
Keep the lyophilised glycoprotein at −20 °C in the freezer. After reconstitution with bacteriostatic water, refrigerate at 2–8 °C and protect from light. Avoid vigorous shaking and repeated freeze-thaw cycles, which can damage the heavily glycosylated structure and reduce bioactivity. This is laboratory handling guidance only.
Where can I buy HCG?
Right here - HCG is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.
How much does HCG cost?
HCG pricing is shown live on this page, per pack size - 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $350.
Is HCG third-party tested?
Yes. Every HCG batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy HCG?
Add the HCG pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step. Every order ships with its batch Certificate of Analysis (COA).
What payment methods can I use to buy HCG?
At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes - we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.
Is it legal to buy HCG?
In the United States, HCG is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction - buyers are responsible for compliance in their own region.
Research use only - all claims made on this site are for testing and research use only.
Pharmacokinetics
Evidence Tier
Overall: Tier 1: Human clinical
Human chorionic gonadotropin is an FDA-approved human pharmaceutical with an extensive clinical and pharmacokinetic literature, so the molecule itself is Tier 1. The research-grade material supplied here is NOT the approved drug - it is unapproved laboratory material for research use only.
Tier 1 · Human clinical
Certificates, databases & peer-reviewed sources
Last reviewed: 16 June 2026 · New-U Research Compounds
Key Characteristics
Specifications
About hCG (Human Chorionic Gonadotropin): LH-Surrogate & Fertility Research Guide
Human chorionic gonadotropin (hCG) is one of the most thoroughly studied gonadotropins in reproductive endocrinology. Its long circulating half-life relative to native luteinizing hormone (LH) made it the standard research tool for sustained activation of the LH/CG receptor (LHCGR), and it has been characterised in published research for over fifty years. Because hCG closely mimics the LH signal, it is the classic probe for Leydig-cell steroidogenesis and ovarian oocyte-maturation studies.
Two structural features matter for research use: the heterodimer architecture (alpha subunit shared with LH, FSH, and TSH; the unique beta subunit determines receptor specificity) and the heavy glycosylation, which accounts for roughly 30% of the molecular mass and is critical for both biological activity and circulating half-life. The same renal clearance of hCG into urine is the molecular basis of every home pregnancy test.
Supplied here as sterile lyophilised glycoprotein for in-vitro and preclinical research only. Activity is reported in IU rather than mg because, like all gonadotropins, hCG is calibrated against an international biological potency standard. It is not a licensed pharmaceutical product and is not a substitute for any prescribed treatment. Nothing on this page is medical advice.
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