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MGF: Muscle / Performance research guide
Not medical advice. MGF is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.
What MGF is
MGF (Mechano Growth Factor) is the native 24-amino-acid E-domain peptide from the IGF-1Ec splice variant - the acute mechanical-loading signal that activates satellite cells as the first phase of skeletal muscle repair.
One-paragraph overview from our research datasheet — still scientific, but faster to read than the full mechanism list below.
MGF (Mechano Growth Factor) 24-amino-acid IGF-1Ec C-terminal E-domain peptide activates satellite cells via non-IGF-1R-mediated nuclear intracrine signaling.
Research contexts
Peer-reviewed literature typically discusses MGF in specific experimental settings. The points below reflect how the scientific community frames this compound—not as health claims, but as the research questions being asked.
Research vs. personal use: Literature describes experiments in controlled lab and animal models. This is distinct from any real-world use; our products are for laboratory research only.
Typical study contexts
Why Muscle / Performance research matters
Here the literature centres on muscle repair, growth-factor signalling, and how tissues respond after overload or injury in preclinical work.
Mechanisms (technical review)
Our datasheet lists mechanistic themes observed in preclinical work. These are research endpoints, not health claims. They help scientists understand and compare pathways.
Lab handling & preparation
Storage requirements: Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation. · Learn best practices in our detailed storage guide.
Research dosing context: Literature typically discusses 200-400 μg per injection site · Immediately post-exercise, bilaterally into trained muscle groups; 2-3 times weekly · Unmodified MGF t½ ~5-7 min, extremely rapid clearance necessitates site-specific intramuscular injection. MW 2848.09 Da (24 aa). Acts in autocrine/paracrine fashion at very low concentrations. Sequence highly conserved across mammalian species (25 aa in most mammals, 24 aa in humans). WADA-prohibited substance. Consider PEG-MGF for systemic applications requiring extended half-life.
Preparation steps: Follow our detailed reconstitution guide, use the calculator tool for volume confirmation, and always verify purity with the COA reading guide.
Common Questions People Are Asking
What does MGF do?
In research models MGF activates quiescent muscle satellite (stem) cells, pushing them from the resting G0 state into proliferation - the first phase of muscle repair after mechanical loading or damage. It acts through a non-IGF-1R nuclear intracrine mechanism rather than the classical IGF-1 receptor, and also shows neuroprotective and pro-angiogenic activity in preclinical work. New-U supplies it for laboratory research only.
How is MGF different from mature IGF-1?
Both come from the same gene, but through different splicing. Mature IGF-1 acts through the IGF-1 receptor to drive protein synthesis and terminal differentiation. MGF's unique C-terminal E-domain (the IGF-1Ec variant) acts through a non-IGF-1R nuclear intracrine mechanism and specifically activates satellite stem cells. They are temporally and functionally sequential steps in muscle repair rather than redundant signals.
What is the half-life of MGF?
Unmodified MGF has a very short circulating half-life - on the order of 5-7 minutes - which is why it is studied as a local autocrine/paracrine signal rather than a systemic one. That short window is the entire reason PEG-MGF exists: PEGylation extends the half-life so the same E-domain signal can act across the whole body from one injection.
How is MGF different from PEG-MGF?
They share the same 24-amino-acid E-domain and the same satellite-cell-activating mechanism, but differ in pharmacokinetics. Native MGF is cleared in minutes and must be injected site-specifically into the target muscle. PEG-MGF carries a polyethylene glycol shield that extends the half-life to hours or days, allowing systemic activation from a single subcutaneous injection.
Why does MGF need to be injected site-specifically?
Because the native peptide has a 5-7 minute half-life. If you inject it subcutaneously, it is cleared long before it can reach distal muscle groups. Site-specific intramuscular injection into the target muscle is the only way to get meaningful local concentrations with native MGF. For systemic protocols, PEG-MGF solves this with a PEG-based half-life extension.
Is MGF banned by WADA?
Yes. MGF and its analogues fall under WADA category S2 (peptide hormones, growth factors, related substances and mimetics) and are prohibited at all times for athletes subject to anti-doping rules. New-U supplies MGF strictly as a research-use-only laboratory compound, not for human use.
How should MGF be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. MGF is not the most stable peptide on the market - use reconstituted material promptly within the normal handling window.
Is this page medical advice? Can I use MGF for my health?
No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.
Where do I find MGF specs, purity certificates and pricing?
Open the shop listing via “View product details.” There you will see batch specs, the Certificate of Analysis (COA), concentration, purity grade, and available SKUs with current pricing.
Related peptide guides
Other compounds researchers often read about alongside MGF.
Scientific sources & further reading
Primary literature and registries for MGF, plus mainstream coverage of the peptide category. Research use only - not medical advice.
Databases & literature:
Peptides in the news:
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Also known as: MGF, Mechano Growth Factor, IGF-1Ec, IGF-1Ec Splice Variant, MGF C-Terminal Peptide, MGF-24aa-E, Satellite Cell Activator
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