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PEG-MGF
Pick your pack · how long it lasts
At 0.600 mg/wk — select pack size
1 × 10-vial pack required for packing — samples add on to any pack
Lab-direct quality — full packs or single-vial samples
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a batch-linked Certificate of Analysis. Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a full sealed 10-vial research pack for a complete study supply, or add a single-vial sample alongside your pack to trial a new compound first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
In plain terms, PEG-MGF is studied as a longer-lasting, whole-body version of the muscle-repair signal MGF. Here is what that looks like across the research.
Whole-body muscle reach
Animal research explores how one injection can reach muscles all over the body, not just at the injection site.
Muscle stem-cell activation
Studied for waking resting muscle stem cells and starting them multiplying, the first step toward growth.
Protein building & repair
Preclinical work looks at how it switches on the protein-synthesis machinery muscle uses to rebuild and repair fibres.
Recovery & muscle wasting
Research examines muscle-fibre repair in age-related muscle loss, wasting and post-injury models.
Longer-acting MGF
Used as a slow-clearing form of MGF so its repair signal can be studied over hours to days instead of minutes.
Overview
PEG-MGF is the PEGylated long-acting form of Mechano Growth Factor, engineered to turn a local 5-minute signal into a systemically active peptide that can reach satellite cells across multiple muscle groups from a single injection.
Native Mechano Growth Factor (MGF) is a 24-residue peptide that the body releases as an early repair signal after muscle damage or heavy mechanical loading. The problem for research use is that native MGF has a circulating half-life of just 5-7 minutes, which limits it to strictly local site-specific injection - inject it into one muscle group and no other muscles see the signal.
PEG-MGF solves that problem by attaching a polyethylene glycol (PEG) chain to the peptide. The PEG shield protects the peptide from being chewed up by enzymes and slows kidney filtration, extending circulating half-life from minutes to several hours or days depending on PEG chain size. That fundamental change in pharmacokinetics converts MGF from a purely local signalling factor into a systemically active peptide.
The practical consequence is that a single subcutaneous injection of PEG-MGF can activate satellite cells across the entire musculature, rather than only at the injection site. Supplied here as sterile lyophilised powder for in-vitro and preclinical research.
Mechanism of Action
PEG-MGF activates satellite cells through a non-IGF-1R nuclear intracrine mechanism, and the PEG shield lets that signal reach muscle groups all over the body rather than just the injection site.
Goldspink (Journal of Anatomy, 2003) characterised native MGF as a mechanical-loading-induced splice variant of IGF-1 with a distinct C-terminal E-domain. The non-IGF-1R satellite-cell activation mechanism makes it functionally different from mature IGF-1, even though both derive from the same gene. PEGylation extends half-life from ~5-7 min to an estimated several hours or days, depending on the PEG chain. Total MW varies with PEG size but the core peptide is ~2867 Da.
Common Questions People Are Asking
What is PEG-MGF?
PEG-MGF is the PEGylated, long-acting form of Mechano Growth Factor - the 24-amino-acid IGF-1Ec E-domain peptide with a polyethylene-glycol chain attached. The PEG shield converts a local, minutes-long satellite-cell signal into a systemically active peptide that can reach muscle groups across the body from a single subcutaneous injection. It is supplied here for laboratory research only and is not for human use.
How is PEG-MGF different from MGF?
They share the same E-domain and the same non-IGF-1R satellite-cell-activating mechanism. The difference is pharmacokinetics: native MGF is cleared in 5-7 minutes and must be injected site-specifically into the target muscle, while PEG-MGF's PEG shield extends the half-life to hours or days, enabling systemic action from one injection. PEG-MGF is the form used in research that needs whole-body or multi-muscle reach.
What is the half-life of PEG-MGF?
PEGylation extends the half-life well beyond native MGF's 5-7 minutes - vendor and educational sources commonly cite a window of many hours up to roughly 48-72 hours depending on PEG chain size. These figures are estimates rather than peer-reviewed human pharmacokinetics; no published human PK study of PEG-MGF exists. The point of the modification is the qualitative shift from a local to a systemic signal.
Why PEGylate MGF instead of just using more of it?
Because the 5-7 minute half-life of native MGF means that injected peptide is degraded or cleared long before it can reach distal muscle groups. No amount of dose escalation fixes that - you would just have higher peak concentrations for the same brief window. PEGylation fundamentally changes the pharmacokinetics rather than just the dose.
Can PEG-MGF be combined with IGF-1 LR3?
Yes - the two peptides operate through different pathways (non-IGF-1R satellite cell activation for MGF; full IGF-1R signalling for IGF-1 LR3) and are sometimes used together in research protocols to target both the stem cell recruitment and terminal differentiation arms of muscle growth.
Is PEG-MGF legal, and is it WADA-banned?
PEG-MGF is sold strictly as a research-use-only laboratory compound and is not an approved drug for human use. For competing athletes it is prohibited at all times under WADA category S2 (peptide hormones, growth factors, related substances and mimetics). New-U supplies it for in-vitro and preclinical research only.
How should PEG-MGF be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The PEG chain improves stability compared with native MGF, but the underlying peptide is still subject to normal handling precautions.
Where can I buy PEG-MGF?
Right here — PEG-MGF is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging. Strictly for laboratory research use only — not for human use.
How much does PEG-MGF cost?
PEG-MGF pricing is shown live on this page, per pack size — 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $300.
Is PEG-MGF third-party tested?
Yes. Every PEG-MGF batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy PEG-MGF?
Add the PEG-MGF pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). PEG-MGF is supplied strictly for laboratory research use only, not for human or veterinary use.
What payment methods can I use to buy PEG-MGF?
At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.
Pharmacokinetics
Evidence Tier
Overall: Tier 3: Anecdotal / self-report
PEG-MGF has no published human pharmacokinetic or clinical study; the extended-half-life figures are vendor/educational estimates, and the evidence base is the preclinical native-MGF literature plus extrapolation. It is not approved by any regulator and is a WADA-prohibited substance.
Tier 2 · Animal
Tier 3 · Anecdotal
Source References & Further Reading
Last reviewed: 16 June 2026 · New-U Research Compounds
Key Characteristics
Specifications
About PEG-MGF: PEGylated Mechano Growth Factor Research Guide
PEG-MGF (PEGylated Mechano Growth Factor) grew out of a very practical problem in muscle growth-factor research. Native MGF, characterised by Geoffrey Goldspink's group at University College London, is a splice variant of IGF-1 (specifically IGF-1Ec) that the body releases in response to mechanical loading. It activates satellite cells - the stem cells of skeletal muscle - through a non-IGF-1R nuclear intracrine mechanism that is distinct from mature IGF-1.
The problem is that native MGF is too short-lived to be a systemic research tool. With a 5-7 minute half-life, it has to be injected directly into the muscle you want to influence, which limits experiments to short-range local effects. PEGylation solves that by attaching a hydrophilic polyethylene-glycol shield to the peptide: the added bulk raises the molecule above the kidney's filtration threshold and blocks proteases, extending circulating half-life from minutes to an estimated several hours or days depending on PEG chain size. (Those extended half-life figures are vendor/educational estimates - there is no published human pharmacokinetic study of PEG-MGF.)
New-U Research Compounds supplies PEG-MGF as a research-grade lyophilised powder at >99% HPLC purity, verified by independent third-party labs. All material is strictly for in-vitro and preclinical research. PEG-MGF is a WADA-prohibited substance (category S2) for competing athletes, is not approved for human therapeutic use, and nothing on this page constitutes medical advice.
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