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PRECISION. PURITY. PERFORMANCE.
Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.
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Research use only (RUO). All products are sold strictly for laboratory and research purposes — not for human or veterinary consumption. Purchasers must be 21 or older.
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Pinealon
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Buy the 10-pack — save 67%/mg
2 single vials minimum for standalone shipping — or add samples to any pack
Lab-direct quality — full packs or single-vial samples
Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity . Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.
Order a full sealed 10-vial research pack for a complete study supply, or add a single-vial sample alongside your pack to trial a new compound first. Same lab, same batch, same verified purity — scaled to whatever your research needs.
What It's Researched For
In plain terms, Pinealon is a three-amino-acid peptide studied for whether it protects brain cells under stress. Here is where the research sits, and where its limits are.
Neuroprotection models
Most published work puts neurons under hypoxic or oxidative stress and asks whether more of them survive.
Gene-expression hypothesis
The programme’s central claim is that peptides this short reach the nucleus and influence which genes are read.
Animal behaviour readouts
Rodent studies report learning and memory endpoints after prenatal-hypoxia insults.
Family comparator
Useful alongside Epitalon and Cartalax for asking whether sequence really determines tissue specificity.
Overview
In short: Pinealon is the tripeptide Glu-Asp-Arg, the brain-associated entry in the Khavinson family of short peptide bioregulators, studied chiefly for neuronal survival under hypoxic and oxidative stress.
Key research facts
Research use only. These points summarise lab themes, not human outcomes.
The peptide-bioregulator programme began with tissue extracts. Researchers at the St Petersburg Institute of Bioregulation and Gerontology isolated peptide fractions from animal organs, observed tissue-specific effects, and then worked to identify the shortest sequences that reproduced them. What emerged was a set of di-, tri- and tetrapeptides — the "cytogens" — each associated with a particular tissue: AEDG (Epitalon) with the pineal gland, AED (Cartalax) with cartilage, and EDR (Pinealon) with brain and neuronal tissue.
Pinealon’s research literature follows that assignment closely. The recurring experimental design places neurons under stress — prenatal hypoxia in rodent models, or oxidative insult in cell culture — and measures whether the peptide improves survival. Reported endpoints include reduced reactive oxygen species, lower apoptosis markers, and, in the animal work, behavioural measures of learning and memory. The proposed mechanism is the programme’s signature claim: that a peptide this small can cross both the cell and nuclear membranes, interact directly with DNA in a sequence-selective way, and shift the expression of a limited set of genes.
That claim deserves careful handling. It is a genuinely unusual mechanism, and the evidence for it comes overwhelmingly from one research programme, published substantially in Russian-language and regional journals, with limited independent replication and no controlled human trials for this specific peptide. The chemistry is straightforward and the compound is well defined, which makes it a tractable subject for exactly the independent work the field is missing. It is supplied here as a research-grade lyophilised powder for in-vitro and preclinical use only, and nothing on this page is medical advice.
Mechanism of Action
The proposed mechanism is direct gene regulation: Pinealon is reported to cross cell and nuclear membranes and bind DNA sequence-selectively, shifting expression of a tissue-limited gene set. Downstream readouts in the literature are antioxidant and anti-apoptotic rather than receptor-mediated.
The short-peptide bioregulator hypothesis sits outside mainstream receptor pharmacology, and that is worth stating plainly rather than glossing. Conventional signalling peptides act at cell-surface receptors; the mechanism proposed for Pinealon and its siblings instead has the peptide functioning as a direct transcriptional modulator, entering the nucleus and contacting DNA. Molecular-modelling and binding studies published within the programme support sequence-selective interaction, and the small size and charge distribution of EDR make membrane passage at least chemically plausible. What the field lacks is independent confirmation — replication from unaffiliated laboratories, and the kind of orthogonal evidence (ChIP-style occupancy data, transcriptome-wide profiling from multiple groups) that would move the claim from plausible to established. For a researcher, that gap defines the useful work: the compound is cheap, chemically simple, stable as a lyophilisate and easy to characterise, which makes basic uptake, localisation and expression-profiling experiments genuinely open ground rather than confirmatory exercises.
Common Questions People Are Asking
What is Pinealon used for in research?
It is studied for neuronal survival under stress — rodent prenatal-hypoxia models and oxidative insult in cultured neurons — with reactive oxygen species, apoptosis markers and behavioural learning and memory measures as the reported endpoints. It also serves as a structure-activity comparator against the other Khavinson cytogens. It is supplied here for laboratory research only and is not for human use.
How does Pinealon relate to Epitalon and Cartalax?
All three come from the same short-peptide bioregulator programme and share its proposed mechanism. They differ in sequence and in the tissue each is associated with: AEDG (Epitalon) with the pineal gland and telomerase research, AED (Cartalax) with cartilage and connective tissue, and EDR (Pinealon) with brain and neuronal tissue. Comparing them directly is one of the more informative experiments available.
How is a three-amino-acid peptide supposed to regulate genes?
The proposal from the originating programme is that peptides this small can pass through cell and nuclear membranes without a dedicated transporter and contact DNA directly, binding particular sequences in promoter regions and altering how much of the associated gene is transcribed. Modelling and binding work within the programme supports it. It is not a conventional receptor mechanism and has not been independently established.
How strong is the evidence for Pinealon?
Weaker than the volume of publications suggests. The animal and cell work is real, but it originates overwhelmingly from a single research programme, appears substantially in Russian-language and regional journals, and has seen limited independent replication. There are no controlled human trials of Pinealon. Treat it as an early-stage research compound rather than a validated tool.
How should Pinealon be stored?
Keep the lyophilised powder frozen at −20 °C, protected from light and moisture. After reconstitution in bacteriostatic water or sterile saline, refrigerate at 1–6 °C and use it promptly — short peptides in solution are prone to hydrolysis and to microbial growth. Aliquot after reconstitution and avoid repeated freeze-thaw cycles where the protocol allows.
Where can I buy Pinealon?
Right here — Pinealon is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging. Strictly for laboratory research use only — not for human use.
How much does Pinealon cost?
Pinealon pricing is shown live on this page, per pack size — 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $300.
Is Pinealon third-party tested?
Yes. Every Pinealon batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.
How do I buy Pinealon?
Add the Pinealon pack size you need to your cart and check out: enter your shipping details, then choose your payment method — cryptocurrency or card — on the next step. Every order ships with its batch Certificate of Analysis (COA). Pinealon is supplied strictly for laboratory research use only, not for human or veterinary use.
What payment methods can I use to buy Pinealon?
At checkout you can pay by cryptocurrency (BTC, ETH, SOL, LTC, USDC, USDT and more) or by card, each handled by a dedicated secure payment provider. You choose your method after confirming your order.
How fast is shipping, and do you ship worldwide?
Yes — we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $300.
Is it legal to buy Pinealon?
In the United States, Pinealon is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction — buyers are responsible for compliance in their own region.
Pharmacokinetics
Evidence Tier
Overall: Tier 3: Anecdotal / self-report
Pinealon has an animal and cell-culture literature covering neuroprotection under hypoxic and oxidative stress, with reported endpoints including reactive oxygen species, apoptosis markers and rodent behavioural measures. The critical qualification is provenance: that body of work originates overwhelmingly from a single research programme and is concentrated in Russian-language and regional journals, with limited independent replication, and the proposed direct-DNA-binding mechanism has not been independently established. There are no controlled human trials of Pinealon. It has no regulatory approval in any jurisdiction and is supplied as unapproved laboratory material.
Tier 2 · Animal
Certificates, databases & peer-reviewed sources
Last reviewed: 6 August 2026 · New-U Research Compounds
Key Characteristics
Specifications
About Pinealon (EDR): Short Peptide Bioregulator Research Guide
Pinealon is a tripeptide — glutamic acid, aspartic acid, arginine — and part of a distinctive research tradition. Beginning in the 1970s, researchers at the St Petersburg Institute of Bioregulation and Gerontology extracted peptide fractions from animal tissues, observed that they produced effects specific to the tissue of origin, and then set about identifying the shortest sequences that carried those effects. The result was a family of very short peptides, the cytogens, each mapped to a tissue: AEDG (Epitalon) to the pineal gland, AED (Cartalax) to cartilage, and EDR (Pinealon) to brain and neuronal tissue.
The research on Pinealon reflects that assignment. Its published studies put neurons under stress and ask whether the peptide helps them survive — prenatal hypoxia in rodents, oxidative insult in cultured cells — and report reductions in reactive oxygen species and apoptosis markers alongside behavioural measures of learning and memory in the animal work. The mechanism proposed is the programme’s defining and most unusual claim: that a peptide of only three residues can cross the cell membrane, enter the nucleus, bind DNA in a sequence-selective manner, and shift the expression of a restricted set of genes. Molecular-modelling and binding studies within the programme support that picture.
Anyone working with this compound should hold the evidence and the claim apart. The mechanism is chemically plausible and internally consistent, but it sits outside mainstream receptor pharmacology, the supporting literature comes overwhelmingly from one programme and is concentrated in Russian-language and regional journals, independent replication is thin, and no controlled human trial of Pinealon exists. That gap is also the opportunity: the molecule is simple, stable and inexpensive to characterise, so uptake, localisation and transcriptome work from unaffiliated laboratories is genuinely open ground. New-U Research Compounds supplies Pinealon as a research-grade lyophilised powder at >98% HPLC purity, strictly for in-vitro and preclinical research use. It is not approved for human therapeutic use in any jurisdiction, and nothing on this page constitutes medical advice or a dosing recommendation.
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