Retatrutide de Investigación – Pureza 99%+

Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and verified to >99% HPLC purity with a published batch Certificate of Analysis. View the batch Certificate of Analysis → Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.

Order a sealed 10-vial research pack , or add a single-vial laboratory sample alongside your pack to evaluate a compound at smaller scale first. Same source, same purity specification — scaled to whatever your research needs.

GLP1-RC-RT Certificate of Analysis

GLP1-RC-RT material is analysed by an independent laboratory, and the resulting Certificate of Analysis is published online. A certificate reports what was measured in the sample submitted; vials are not batch-marked, so it is not matched to a particular vial or order.

New-U GLP1-RC-RT certificate evidence

Catalogue identifier: GLP1-RC-RT

Independent testing laboratory, report number and test date

Measured purity for the sample analysed

Certificate of Analysis at /coa/retatrutide; the method and any identity result are stated on the report

Batch analysis reports identity and purity for the sample tested. It does not establish sterility, endotoxin or heavy-metal status, pharmaceutical equivalence, or any clinical property.

Published scientific literature

External experimental and clinical studies

Receptor pharmacology and pharmacokinetics

Protocol-defined trial endpoints and timepoints

Adverse events recorded by investigators

Registered trial records and peer-reviewed citations (DOI / PMID / NCT)

Published clinical findings summarised on this page relate to the investigational materials and protocols used in those external studies. They do not establish the safety, efficacy, intended use or clinical equivalence of New-U GLP1-RC-RT research material.

Áreas de investigación publicadas

Los estudios publicados examinan actividad de receptores, farmacocinética y variables metabólicas, hepáticas y glucémicas definidas por protocolo. Los resúmenes siguientes informan de lo que los investigadores midieron en esos estudios externos y no constituyen instrucciones de uso para el material de investigación suministrado aquí.

Farmacología de receptores

Actividad agonista GLP-1R / GIPR / GCGR, caracterizada en estudios publicados in-vitro de receptores.

Variables metabólicas

Cambio respecto al valor basal de la masa corporal definido por protocolo, medido en investigación clínica aleatorizada.

Variables hepáticas

Fracción de grasa hepática por MRI-PDFF, medida en un subestudio aleatorizado Phase 2a.

Variables glucémicas

HbA1c y variables relacionadas con la glucosa, comunicadas en investigación clínica definida por protocolo.

Farmacocinética

Exposición sistémica y semivida aparente de eliminación, a partir de la caracterización farmacocinética publicada.

Scientific Overview

In short: GLP1-RC-RT es un compuesto de investigación agonista triple de GLP-1R / GIPR / GCGR, denominado habitualmente “Reta” en comunidades de investigación.

Key research facts

Farmacología de receptores: actividad agonista caracterizada en GLP-1R, GIPR y GCGR en estudios in-vitro publicados

Potencia en GIPR comunicada como 8.9 veces la de GIP nativo en estudios de farmacología de receptores

Modificación C20 fatty-diacid con unión a albúmina investigada como factor contribuyente a una exposición sistémica prolongada

RCT Phase 2 de obesidad (NEJM 2023, PMID 37385275): los investigadores comunicaron un cambio medio de −24.2% respecto al valor basal del peso corporal en la semana 48 (brazo de 12 mg)

Phase 3 TRIUMPH-1 (NCT05929066; resultado principal comunicado por el patrocinador, ADA 2026; todavía no revisado por pares): los investigadores comunicaron un cambio medio de −28.3% respecto al valor basal del peso corporal en la semana 80 (brazo de 12 mg)

These points summarise lab themes, not human outcomes.

Los trabajos publicados caracterizan la farmacología de receptores, las modificaciones estructurales y el perfil farmacocinético de esta clase de compuestos, junto con variables definidas por protocolo investigadas en investigación preclínica y clínica registrada.

La verificación de lotes de New-U y la literatura externa son conjuntos de evidencia independientes: los análisis del lote establecen la identidad analítica y la pureza del material analizado; los estudios publicados describen sus propios materiales y protocolos de investigación.

Arquitectura molecular

Retatrutide (LY3437943) es un péptido diseñado de 39 aminoácidos con un peso molecular de 4,894.6 Da, caracterizado en estudios de farmacología de receptores como agonista de tres receptores: GLP-1, GIP y glucagon. Este perfil de tres receptores se denomina en la literatura triagonista "GGG".

Farmacología de receptores

Los valores EC50 comunicados son 0.775 nM en GLP-1R, 0.0643 nM en GIPR y 5.79 nM en GCGR, con una potencia en GIPR comunicada como 8.9 veces la de GIP nativo. En relación con la clase dual GLP-1/GIP, el brazo adicional investigado es el agonismo del glucagon-receptor; los trabajos publicados examinan variables de gasto energético hepático asociadas a ese brazo junto con las variables incretin medidas para la clase en su conjunto. Tabla completa de la vía: Mechanism of Action a continuación.

Modificaciones estructurales

El backbone derivado de GIP incorpora sustituciones Aib2 y Aib20 investigadas por su resistencia a DPP-IV y α-methylleucine en la posición 13 investigada por su estabilidad frente a proteasas. Un C20 fatty diacid unido a Lys17 mediante un espaciador AEEA-γGlu se investiga como factor de unión a albúmina que contribuye a una exposición sistémica prolongada.

Farmacocinética publicada

La semivida aparente de eliminación se sitúa en aproximadamente 6 días según los protocolos investigados, con metabolismo proteolítico hepático y sin interacciones mediadas por CYP comunicadas. Perfil farmacocinético completo: Pharmacokinetics a continuación.

Investigación preclínica y clínica

Los hallazgos publicados resumidos en esta página se refieren a estudios experimentales y clínicos externos y a sus respectivos materiales y protocolos investigacionales. No establecen la seguridad, eficacia ni equivalencia clínica del material GLP1-RC-RT de New-U. Resultados ensayo por ensayo: Research Observed Effects y Evidence Tier a continuación.

Referencias principales

Las publicaciones revisadas por pares y el registro de ensayo clínico registrado para Retatrutide se enumeran íntegramente, con identificadores DOI/PMID/NCT, en Source References a continuación.

At a glance

Mechanism and receptors Published experimental work characterises agonist activity across GLP-1R, GIPR and GCGR, with structural modifications investigated for proteolytic stability and prolonged systemic exposure.

Molecular characteristics Molecular weight 4,894.6 Da.

Pharmacokinetics Half-life: Apparent elimination half-life reported at approximately 6 days under the investigated protocols; steady-state exposure reported after 3–4 weeks.

Evidence maturity Tier 1: Human clinical — The evidence tier describes the published literature on Retatrutide, the scientific subject. Retatrutide remains investigational and is not approved in any jurisdiction.

Analytical verification Batch analysis reports identity and purity for the sample tested. It does not establish sterility, endotoxin or heavy-metal status, pharmaceutical equivalence, or any clinical property.

Research limitations Published clinical findings summarised on this page relate to the investigational materials and protocols used in those external studies. They do not establish the safety, efficacy, intended use or clinical equivalence of New-U GLP1-RC-RT research material.

Receptor Pharmacology

Published experimental work characterises agonist activity across GLP-1R, GIPR and GCGR, with structural modifications investigated for proteolytic stability and prolonged systemic exposure.

Pathway Effect Why it matters GLP-1R Agonist activity characterised in receptor pharmacology studies Reported EC50 0.775 nM; the receptor shared with the single- and dual-agonist reference compounds GIPR Agonist activity characterised experimentally Reported EC50 0.0643 nM; potency reported as 8.9-fold that of native GIP GCGR Agonist activity characterised experimentally Reported EC50 5.79 nM; the arm that distinguishes the triple agonist from dual GLP-1/GIP compounds in the literature Albumin-binding modification C20 fatty diacid via an AEEA-γGlu spacer Investigated as a contributor to prolonged systemic exposure (~6-day apparent half-life) Proteolytic stability Aib2, Aib20 and α-methylleucine-13 substitutions Structural modifications investigated for altered peptide stability against DPP-IV and protease cleavage

Deeper dive for scientific readers

Jastreboff et al. (N Engl J Med, 2023; PMID 37385275, DOI 10.1056/NEJMoa2301972) published the randomised Phase 2 obesity data: in the 12 mg arm investigators reported a mean change from baseline in body weight of −24.2% at week 48, with more than 90% of participants in that arm reaching a ≥10% reduction. Sanyal et al. (Nat Med, 2024; DOI 10.1038/s41591-024-03018-2) reported relative reductions in hepatic fat fraction of up to 82.4% in a Phase 2a MASLD population. The Phase 3 TRIUMPH-1 trial (NCT05929066) reported a mean change from baseline in body weight of −28.3% at week 80 in the 12 mg arm, with 45.3% of that arm reaching a ≥30% reduction — sponsor-reported topline, ADA 2026; not yet peer-reviewed. Published pharmacokinetic work reports hepatic proteolytic metabolism without CYP involvement and steady-state exposure after 3–4 weeks of the protocol-defined weekly administration. Every figure here is an observation recorded in the cited external study of the investigational compound.

Common Questions People Are Asking

¿Qué es GLP1-RC-RT?

GLP1-RC-RT es la designación de catálogo de New-U para este compuesto de investigación verificado analíticamente, denominado habitualmente “Reta” en comunidades de investigación. Se suministra como material para investigación de laboratorio: no es un medicamento, un tratamiento, un producto farmacéutico genérico ni un producto terapéutico, no es equivalente a ningún producto clínico o comercial y no se ofrece para uso humano ni veterinario.

¿Qué sistemas receptores se han investigado?

La farmacología in-vitro publicada caracteriza actividad agonista en tres receptores: GLP-1R (EC50 comunicada 0.775 nM), GIPR (EC50 comunicada 0.0643 nM, con una potencia comunicada como 8.9 veces la de GIP nativo) y GCGR (EC50 comunicada 5.79 nM). Los trabajos estructurales investigan además la modificación C20 fatty-diacid de unión a albúmina como contribuyente a una exposición sistémica prolongada y sustituciones Aib/α-methylleucine para modificar la estabilidad proteolítica.

¿Qué análisis analíticos acompañan a GLP1-RC-RT?

The published GLP1-RC-RT Certificate of Analysis comes from an independent analytical laboratory and records the independent laboratory, report number, measured purity and test date for the sample analysed; the method and any identity result are stated on the report itself. Vials are not batch-marked, so a certificate describes the sample tested rather than a particular vial or order. Batch analysis reports identity and purity for the sample tested. It does not establish sterility, endotoxin or heavy-metal status, pharmaceutical equivalence, or any clinical property.

Where can I view the current Certificate of Analysis for GLP1-RC-RT?

The current certificate — laboratory, report number, measured purity and test date — is published at /coa/retatrutide, together with the testing history for the compound. It is readable before ordering rather than on request afterwards.

¿Qué significa una pureza HPLC >99%?

Es una cifra de pureza obtenida mediante reversed-phase high-performance liquid chromatography utilizando normalización de área: el pico objetivo representa más del 99% del área total integrada de picos del cromatograma de la muestra analizada. Es una afirmación únicamente sobre la pureza química de esa muestra. No describe esterilidad, contenido de endotoxinas, contenido de metales pesados, equivalencia farmacéutica ni ninguna propiedad clínica.

¿Qué ensayos clínicos se citan en esta página?

Tres estudios externos del compuesto investigacional: el ensayo aleatorizado Phase 2 de obesidad (Jastreboff et al., N Engl J Med 2023; PMID 37385275, DOI 10.1056/NEJMoa2301972), el ensayo Phase 2a de MASLD (Sanyal et al., Nat Med 2024; DOI 10.1038/s41591-024-03018-2) y el ensayo Phase 3 TRIUMPH-1 (ClinicalTrials.gov NCT05929066). Cada resultado comunicado en esta página se atribuye a su estudio, brazo y momento temporal. Las cifras de TRIUMPH-1 son datos principales comunicados por el patrocinador y presentados en ADA 2026, y aún no han sido revisadas por pares; las cifras de Phase 2 y Phase 2a proceden de publicaciones de revistas revisadas por pares.

¿Cómo se distingue la investigación clínica publicada de los análisis de lotes de New-U?

They are separate bodies of evidence and this page keeps them apart. Published clinical research is external work on Retatrutide as an investigational compound, using those studies' own materials and protocols; it establishes nothing about the material supplied here. New-U certificate testing is analytical work on a submitted sample of the GLP1-RC-RT material: the published report states the measured result for the sample analysed, and it establishes nothing clinical. A certificate of analysis combined with an external clinical paper does not amount to clinical validation of GLP1-RC-RT.

¿En qué forma se suministra GLP1-RC-RT?

GLP1-RC-RT is supplied as a lyophilised powder in sealed vials, in single-vial laboratory samples and sealed 10-vial research packs across the listed strengths; the Certificate of Analysis is published on the product page.

¿Cómo debe almacenarse el material de investigación de laboratorio?

Conservar el polvo liofilizado en un congelador a −20 °C. Si un protocolo de laboratorio requiere el material en solución, mantener la solución resultante refrigerada a 1–6 °C, protegida de la luz y evitar ciclos repetidos de congelación-descongelación, que pueden degradar la modificación de fatty-acid. Las condiciones de almacenamiento son únicamente información de manipulación de laboratorio.

¿En qué se diferencia este perfil de receptores de los agonistas duales y simples?

Las tres clases se distinguen por la cobertura de receptores: la literatura de semaglutide describe agonismo de GLP-1R, la literatura de tirzepatide describe agonismo de GIPR/GLP-1R y este compuesto se investiga por agonismo de GLP-1R/GIPR/GCGR. Sus programas clínicos se realizaron por separado, por lo que los resultados publicados de un programa no son comparaciones directas frente a otro.

¿Es GLP1-RC-RT un medicamento aprobado?

No. El compuesto asociado es investigacional y se está evaluando en estudios clínicos registrados; no está aprobado en ninguna jurisdicción. El material suministrado aquí es material para investigación de laboratorio y no se ofrece como medicamento, producto terapéutico ni material para uso humano o veterinario.

Is it legal to buy Retatrutide?

In the United States, Retatrutide is sold strictly for laboratory and research purposes only. It is not approved by the FDA for human consumption and is not sold for that purpose. Regulatory status varies by jurisdiction - buyers are responsible for compliance in their own region.

Research use only - all claims made on this site are for testing and research use only.

Pharmacokinetics

Half-life Apparent elimination half-life reported at approximately 6 days under the investigated protocols; steady-state exposure reported after 3–4 weeks Absorption route Study protocols used subcutaneous administration; reported Tmax 12–72 h with dose-proportional (linear) exposure Bioavailability High subcutaneous exposure with dose-proportional plasma levels reported Metabolism / clearance Hepatic proteolytic metabolism plus β-oxidation of the C20 fatty-diacid chain reported; no CYP-mediated interactions reported Stability Laboratory handling — lyophilised: −20 °C. Reconstituted: 1–6 °C, protect from light; avoid repeated freeze–thaw Notes The C20 fatty-diacid/albumin interaction is the protraction mechanism described in the published pharmacokinetic literature. These are pharmacokinetic observations from external studies of the investigational compound, not a handling or administration instruction for research material.

Research-Observed Effects

Phase 3 TRIUMPH-1 (NCT05929066), obesity/overweight population, 12 mg arm: investigators reported a mean change from baseline in body weight of −28.3% at week 80; 45.3% of that arm reached ≥30% reduction (sponsor-reported topline, ADA 2026; not yet peer-reviewed)

Phase 2 obesity RCT (Jastreboff et al., NEJM 2023; PMID 37385275), 12 mg arm: investigators reported a mean change from baseline in body weight of −24.2% at week 48, with >90% of that arm reaching ≥10% reduction

Phase 2a MASLD trial (Sanyal et al., Nat Med 2024): investigators reported relative hepatic fat-fraction reductions of up to 82.4% at the protocol-defined timepoint, with steatosis resolution reported in >90% of the 12 mg arm

Type 2 diabetes studies: investigators reported HbA1c reductions of 1.3–2.0% as a protocol-defined endpoint in the investigated arms

Experimental pharmacology: glucagon-receptor agonism is investigated in the literature as a contributor to hepatic energy-expenditure endpoints measured alongside the incretin endpoints

Published Research Context

Registered clinical research of the investigational compound used protocol-defined intervention arms. The Phase 2 programme included 1 mg, 4 mg, 8 mg and 12 mg arms; the Phase 3 TRIUMPH-1 trial randomised 4 mg, 9 mg and 12 mg arms against placebo. Study protocols used once-weekly subcutaneous administration with a protocol-defined step-up period of roughly 20–24 weeks before the maintenance arm level was reached.

These figures are characteristics of external clinical trials. They are recorded here as scientific study context and are not a protocol, schedule, starting point or instruction for any use of laboratory research material.

Adverse Events Reported in Published Clinical Research

The events below were recorded by investigators in published clinical trials of the investigational compound. They describe what was observed in those study populations under those protocols; they are not a prediction of, or guidance about, anything a reader may experience.

Common

Nausea — reported as the most frequent event, described as escalation-related and typically transient

Diarrhoea

Vomiting

Constipation

Decreased appetite recorded as a reported adverse event

Rare

Discontinuation due to adverse events, reported by arm in TRIUMPH-1: 4.1% (4 mg), 6.9% (9 mg), 11.3% (12 mg) vs 4.9% placebo

Transient increase in resting heart rate

Transient glucose elevation attributed to the glucagon-receptor arm, monitored under the study protocols

Dose-dependent

Investigators reported gastrointestinal events scaling with arm level and during the protocol-defined step-up period, attenuating at steady state

Higher arm levels were reported with both larger endpoint changes and a higher adverse-event discontinuation rate

Evidence Tier

Overall: Tier 1: Human clinical

The evidence tier describes the published literature on Retatrutide, the scientific subject. Retatrutide remains investigational and is not approved in any jurisdiction. Published clinical findings summarised on this page relate to the investigational materials and protocols used in those external studies. They do not establish the safety, efficacy, intended use or clinical equivalence of New-U GLP1-RC-RT research material.

Tier 1 · Human clinical

TRIUMPH-1 pivotal Phase 3 obesity RCT — −28.3% mean change from baseline in body weight at week 80 (NCT05929066; sponsor-reported topline, ADA 2026; not yet peer-reviewed)

Triple-agonist Phase 2 obesity RCT — −24.2% mean change from baseline at week 48 (NEJM 2023; PMID 37385275)

Phase 2a MASLD trial — up to 82.4% relative hepatic fat-fraction reduction (Nat Med 2024)

Certificates, databases & peer-reviewed sources

Last reviewed: 14 August 2026 · New-U Research Compounds

Jastreboff AM et al. Triple–Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial. N Engl J Med. · 2023 · PMID: 37385275 · DOI: 10.1056/NEJMoa2301972

Sanyal AJ et al. Triple hormone receptor agonist retatrutide for MASLD: a randomized phase 2a trial. Nat Med. · 2024 · DOI: 10.1038/s41591-024-03018-2

TRIUMPH-1: A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight - Phase 3 (Pivotal). ClinicalTrials.gov trial registration record. · 2023

Eli Lilly and Company. Lilly’s triple agonist, retatrutide, delivered powerful weight loss in pivotal Phase 3 obesity trial. Sponsor announcement (topline; not peer-reviewed), presented at ADA 86th Scientific Sessions. · 2026

Katsi V, Koutsopoulos G, Fragoulis C, Dimitriadis K, Tsioufis K. Retatrutide - A Game Changer in Obesity Pharmacotherapy. Biomolecules (review). · 2025 · PMID: 40563436 · DOI: 10.3390/biom15060796

PubMed: peer-reviewed literature on Retatrutide

ClinicalTrials.gov: registered studies on Retatrutide

Retatrutide: Wikipedia (search)

WebMD: consumer health reference

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Key Characteristics

Engineered 39-amino-acid peptide (LY3437943)

Agonist activity characterised at GLP-1R, GIPR and GCGR in receptor-pharmacology studies

GIPR potency reported as 8.9-fold that of native GIP

C20 fatty-diacid albumin-binding modification investigated for prolonged systemic exposure

Apparent elimination half-life reported at approximately 6 days in published pharmacokinetic research

GLP1-RC-RT laboratory research material — analytically verified, >99% HPLC purity

Supplied as lyophilised powder for laboratory research; not an approved medicine

Specifications

Identificador de catálogo de New-U GLP1-RC-RT Objeto científico Retatrutide (LY3437943) Fórmula molecular Lipopéptido complejo (conjugado C20 diacid) Peso molecular 4894.6 Da Receptores caracterizados GLP-1R (EC50 0.775 nM), GIPR (EC50 0.064 nM), GCGR (EC50 5.79 nM) Pureza (analítica) >99% por normalización de área RP-HPLC Identidad (analítica) Stated on the published Certificate of Analysis where the report includes an identity test Forma Polvo liofilizado Semivida publicada Aproximadamente 6 días (investigación farmacocinética externa) Conservación Liofilizado: congelador a −20 °C. Reconstituido: 1-6 °C, protegido de la luz. Uso previsto Laboratory research material. Not for human or veterinary use.

Retatrutide Research — GLP1-RC-RT Laboratory Research Material

Retatrutide (LY3437943) is investigated in the literature as the triple-receptor entrant in the incretin class. First-generation compounds such as semaglutide are characterised as GLP-1R agonists; dual compounds such as tirzepatide are characterised as GIPR/GLP-1R agonists; retatrutide adds glucagon-receptor agonism, which is why it is described as a "GGG" tri-agonist.

Published clinical research reports protocol-defined endpoints: a mean change from baseline in body weight of −24.2% at week 48 in the Phase 2 12 mg arm (NEJM 2023), −28.3% at week 80 in the Phase 3 TRIUMPH-1 12 mg arm (sponsor-reported topline, ADA 2026; not yet peer-reviewed), and relative hepatic fat-fraction reductions of up to 82.4% in a Phase 2a MASLD population (Nat Med 2024). Each of those figures belongs to the study that produced it, in the population and at the timepoint that study defined.

New-U Research Compounds supplies GLP1-RC-RT as lyophilised, analytically verified laboratory research material; its published independent Certificate of Analysis records the independent laboratory, report number, measured purity and test date for the sample analysed. Batch analysis reports identity and purity for the sample tested. It does not establish sterility, endotoxin or heavy-metal status, pharmaceutical equivalence, or any clinical property. Published clinical findings summarised on this page relate to the investigational materials and protocols used in those external studies. They do not establish the safety, efficacy, intended use or clinical equivalence of New-U GLP1-RC-RT research material. GLP1-RC-RT is not an approved medicine and is not offered for human or veterinary use.

Glucagon-like peptide-1 - Wikipedia

Gastric inhibitory polypeptide - Wikipedia

Glucagon - Wikipedia

Customer Reviews

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Retatrutide vs related Metabolic Research compounds

Compound Price Purity spec COA Retatrutide from $160 >99% HPLC 4 published batches Semaglutide from $106 >99% HPLC 1 published batch Tirzepatide from $168 >99% HPLC 2 published batches

Retatrutide vs Semaglutide - full comparison

Retatrutide vs Tirzepatide - full comparison

Descriptive catalog comparison for research sourcing decisions - not dosing guidance.

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Research guide Retatrutide research guide Published experimental work characterises agonist activity across GLP-1R, GIPR and GCGR, with structural modifications investigated for… Read the guide →

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Analytical evidence View the Retatrutide COA Latest published certificate of analysis (purity and identity), dated 2026-07-24. View the COA →

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Research peptides. Third-party Certificates of Analysis (Janoshik Analytical & Freedom Diagnostics) are published on the website. Supplied strictly for laboratory research use.

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