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  • Melanotan-2

    • Melanotan-2

    Melanotan II cyclic heptapeptide non-selectively agonizes MC1R/MC3R/MC4R/MC5R for melanogenesis, appetite modulation, and sexual arousal research applications.

    This strength is out of stock. Pick another strength, or check back soon — restocks are frequent.

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    Melanotan-2

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    Every batch ships straight from the lab that synthesises it — sealed, tamper-evident, and HPLC-verified to >99% purity with a published batch Certificate of Analysis. View the batch Certificate of Analysis → Buying direct means you pay the lab-direct rate on every vial, with nothing stacked on top.

    Order a sealed 10-vial research pack , or add a single-vial laboratory sample alongside your pack to evaluate a compound at smaller scale first. Same lab, same batch, same verified purity — scaled to whatever your research needs.

    What It's Researched For

    In plain terms, Melanotan-2 is studied for skin tanning plus libido and appetite, because it hits several melanocortin receptors at once. Here is what that looks like across the research.

    Tanning & skin pigment

    Research explores how it darkens the skin by switching on natural pigment production, with little or no sun needed. Small early human studies and animal work both look at this.

    Libido & sexual function

    Animal studies and early human research investigate its effect on arousal and sexual function, the brain pathway that later inspired the FDA-approved PT-141.

    Appetite & body weight

    Animal studies look at reduced food intake and changes in body composition through the brain's appetite circuits.

    Melanocortin biology tool

    Used in research as a benchmark compound for mapping how the melanocortin receptor family works.

    Overview

    In short: Melanotan-2 (MT-2) is a cyclic non-selective melanocortin receptor agonist studied for UV-independent skin pigmentation, appetite modulation, and sexual arousal research.

    Key research facts

  • MC1R agonism activates cAMP-PKA-CREB-MITF cascade for tyrosinase-driven eumelanin biosynthesis
  • MC4R activation in hypothalamic nuclei modulates sexual arousal through central neuroendocrine pathways
  • Appetite suppression via MC4R-mediated anorexigenic signaling in arcuate nucleus neurons
  • Crosses blood-brain barrier due to cyclic lactam structure and lipophilic modifications
  • Preserves His-D-Phe-Arg-Trp melanocortin pharmacophore with enhanced proteolytic stability over linear α-MSH

    • These points summarise lab themes, not human outcomes.

    Melanotan-2 is a lab-engineered shortened and cyclised version of α-MSH, the natural hormone your body uses to trigger tanning. The modifications make it far more resistant to enzyme breakdown and much more potent than the natural molecule at binding all four melanocortin receptors.

    Because MT-2 is non-selective, it hits the receptors that control pigmentation (MC1R), sexual arousal and appetite (MC4R), and exocrine function (MC5R) at the same time. In research this produces the characteristic triple signature: darker pigmentation, reduced food intake, and upregulated libido in animal models.

    Unlike its selective cousin afamelanotide (Melanotan-1), MT-2 is not approved for any human therapeutic use. It is a research compound only, and its non-selective profile is part of why bremelanotide (PT-141) was later developed as a more targeted MC4R agonist.

    Research Video

    Mechanism of Action

    MT-2 binds all four melanocortin receptors, triggering melanin production in the skin and activating appetite and arousal circuits in the brain.

    Pathway Effect Why it matters MC1R (skin) Activates cAMP/PKA/CREB/MITF to turn on tyrosinase Produces eumelanin, the dark pigment that provides UV protection MC4R (hypothalamus) Reduces food intake and triggers arousal signalling Drives both appetite suppression and pro-erectile effects MC3R (energy balance) Modulates nutrient partitioning and metabolism Contributes to body-composition changes seen in animal models MC5R (exocrine) Stimulates sebaceous and lacrimal secretion Explains facial flushing and oily skin sometimes seen in research protocols Cyclic lactam bridge Locks the peptide into an active conformation Protects against proteolytic breakdown and extends duration of action Deeper dive for scientific readers

    Hruby and colleagues (Journal of Medicinal Chemistry, 1995) designed MT-2 as a lactam-bridged cyclic heptapeptide preserving the conserved His-D-Phe-Arg-Trp pharmacophore. The D-Phe7 substitution confers protease resistance and superpotent receptor binding. Rat PK (Ugwu et al., Pharmaceutical Research, 1994) gives an IV t½ of 0.5-1.5 h, Vss 0.2-0.5 L/kg, and ~4.6% oral bioavailability. Because MT-2 crosses the blood-brain barrier, receptor activation is both peripheral and central - which is why nausea and facial flushing are the most commonly reported side effects in research.

    Common Questions People Are Asking

    What is Melanotan-2?

    Melanotan-2 (MT-2) is a synthetic cyclic heptapeptide analogue of α-MSH (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂, MW 1024.18 Da) that non-selectively activates the MC1R, MC3R, MC4R and MC5R melanocortin receptors. It is supplied as a lyophilised research-grade powder for laboratory use only - it is not approved for human use.

    What does Melanotan-2 do?

    In research models MT-2 activates MC1R to stimulate eumelanin synthesis (the pathway behind UV-independent pigmentation), and activates MC4R in the hypothalamus, which is associated with appetite suppression and arousal signalling. These are findings in animal/research models; New-U makes no human-use or cosmetic claims.

    Does Melanotan-2 work without sun?

    Because MT-2 stimulates melanocyte MC1R directly, melanogenesis can be triggered in research models with little or no UV exposure - unlike a normal tan that requires sunlight. Published observations note that UV exposure still substantially accelerates and deepens the studied pigmentation response. This is research context only, not a cosmetic or human-use recommendation.

    Does Melanotan-2 change eye color?

    There is no credible scientific evidence that MT-2 changes iris (eye) colour. The melanocytes it acts on are in the skin and hair; the documented pigmentation effects are darker skin and darkening of existing moles/freckles, not eye colour. Reported for research context only.

    How is Melanotan-2 reconstituted?

    Lyophilised MT-2 is dissolved in bacteriostatic water for multi-use research vials. Concentration in mg/mL equals the vial mass in mg divided by the millilitres of diluent added - e.g. a 10 mg vial reconstituted with 1 mL gives 10 mg/mL. Keep the reconstituted vial refrigerated at 1–6 °C and protected from light. This is laboratory preparation math only; no human-use dosing guidance is provided.

    What is the difference between Melanotan-1 and Melanotan-2?

    Melanotan-1 (afamelanotide) is a linear 13-amino-acid α-MSH analog that is more selective for MC1R and is EMA/FDA-approved as Scenesse for erythropoietic protoporphyria. Melanotan-2 is a smaller cyclic heptapeptide that activates MC1R, MC3R, MC4R, and MC5R non-selectively, producing broader effects and more side effects.

    Why does Melanotan-2 cause nausea and facial flushing?

    Those effects come from non-selective activation of MC4R and MC5R in the brain and exocrine glands. MC4R activation in hypothalamic nuclei drives both appetite suppression and nausea, while MC5R stimulates sebaceous secretion and vasomotor responses that show up as facial flushing.

    How does Melanotan-2 relate to PT-141?

    PT-141 (bremelanotide) is essentially an active metabolite of Melanotan-2 with a free carboxylic acid instead of an amide at the C-terminus. It is more selective for MC4R-mediated sexual arousal pathways and is FDA-approved as Vyleesi for generalised HSDD in premenopausal women.

    How should Melanotan-2 be stored?

    Keep lyophilised powder at −20 °C in the freezer. Once reconstituted with bacteriostatic water, refrigerate at 1-6 °C and protect from light. Reconstituted solutions are generally stable for several weeks under those conditions.

    What Melanotan-2 dosage is described in research?

    The research literature typically describes a low-microgram subcutaneous "loading" phase followed by smaller intermittent "maintenance" amounts, with melanogenesis driving the studied pigmentation response. New-U publishes this only as descriptive research context - it is not a dosing instruction.

    What does Melanotan-2 before and after show in studies?

    In pigmentation research, MC1R activation increases eumelanin synthesis, so studied endpoints describe a gradual darkening over roughly 1-4 weeks of repeated exposure that fades once dosing stops. Magnitude depends heavily on baseline skin type, amount and UV exposure. Reported for research context only - not a cosmetic or human-use claim.

    How long does Melanotan-2 take to work and how long does it last?

    Pigmentation is cumulative rather than immediate: pigmentation research describes a gradual darkening building over roughly 1-4 weeks of repeated low-dose exposure, then fading over weeks once dosing stops as melanocytes turn over. The peptide itself clears quickly (rodent IV half-life ~0.5-1.5 h) but the studied pigment effect outlasts the circulating compound. These are descriptive research-context observations, not human-use or cosmetic guidance.

    What are the side effects of Melanotan-2 reported in research?

    The literature most commonly reports nausea, facial flushing, appetite suppression and darkening of existing moles/freckles, arising from non-selective MC3R/MC4R/MC5R activation. New-U supplies Melanotan-2 as a research compound only and makes no safety or human-use claims; these are summarised research findings, not medical advice.

    Is Melanotan-2 legal, and is it FDA-approved?

    Melanotan-2 is not approved by the FDA, EMA or any major regulator for human use - only the related, more selective afamelanotide (Melanotan-1 / Scenesse) and bremelanotide (PT-141 / Vyleesi) hold approvals for specific indications. Melanotan-2 is sold in the US strictly as a research compound; buyers are responsible for compliance in their jurisdiction.

    Where can I buy Melanotan-2?

    Right here - Melanotan-2 is supplied directly by New-U Research Compounds on this page. Every batch is independently third-party tested to >99% HPLC purity with a batch-linked Certificate of Analysis, supplied as lyophilised research-grade material, and shipped direct from source worldwide in discreet, tracked packaging.

    How much does Melanotan-2 cost?

    Melanotan-2 pricing is shown live on this page, per pack size - 10-vial research packs as standard, with single-vial sample options on selected compounds. Larger vial strengths lower the per-mg cost, every order includes the batch Certificate of Analysis, and shipping is free on orders over $350.

    Is Melanotan-2 third-party tested?

    Yes. Every Melanotan-2 batch is verified by independent laboratories (Janoshik Analytics and Freedom Diagnostics) for identity and purity, with a batch-linked Certificate of Analysis confirming >99% purity by HPLC. Every order ships with its COA, and current batch certificates are published on our COA page.

    How do I buy Melanotan-2?

    Add the Melanotan-2 pack size you need to your cart and check out: enter your shipping details, then choose your payment method - cryptocurrency or card - on the next step. Every order ships with its batch Certificate of Analysis (COA).

    What payment methods can I use to buy Melanotan-2?

    At checkout you can pay by card or crypto. New-U supports BTC and selected stablecoin and network-asset payments across Ethereum, Solana, TRON, Polygon, Base, BNB Chain and Linea. You choose your method after confirming your order.

    How fast is shipping, and do you ship worldwide?

    Yes - we ship worldwide in discreet, unmarked, temperature-stable, tracked packaging. Delivery typically takes 6–14 business days, and shipping is free on orders over $350.

    Research use only - all claims made on this site are for testing and research use only.

    Pharmacokinetics

    Half-life ~0.5-1.5 h (IV, rat); functional duration extends 24-36 h subcutaneously Absorption route Subcutaneous; Tmax 0.5-1 h (rodent models) Bioavailability ~4.6% oral (rat, Ugwu et al. 1994); ~100% subcutaneous Metabolism / clearance Proteolytic cleavage; cyclic lactam bridge resists enzymatic degradation vs. linear α-MSH Stability Lyophilised: −20 °C freezer. Reconstituted with bacteriostatic water: refrigerate 1-6 °C, protect from light; stable several weeks. Notes Vss 0.2-0.5 L/kg; CL ~0.3 L/kg/h. Crosses the blood-brain barrier, producing both peripheral and central effects.

    Research-Observed Effects

  • UV-independent cutaneous pigmentation (MC1R-mediated eumelanogenesis)
  • Reduced caloric intake in rodent obesity models
  • Increased copulatory behaviour in male rat models (pro-erectile)
  • Facial flushing and transient sebaceous upregulation
  • Transient nausea following early doses (tachyphylaxis with repeated dosing)
  • Darkening of pre-existing nevi and appearance of new pigmented macules

    • Dosage Ranges (Research Context)

    Research-context subcutaneous dosing reported in the literature. Not a clinical recommendation.

    Dose Frequency Duration Notes 0.025-0.1 mg Microdose titration (research protocols) 3-7 days Used in some protocols to assess tolerability before escalation 0.25-0.5 mg Once daily (loading) 1-2 weeks Subcutaneous; most commonly reported loading phase in self-experiment literature 0.5-1.0 mg 2-3× per week (maintenance) Ongoing Titrate to desired pigmentation endpoint

    Stacking Compatibility

    Compatible compounds

  • PT-141 (bremelanotide): Same melanocortin family; PT-141 is more MC4R-selective for targeted arousal research without layering MC1R pigmentation effects.
  • GHK-Cu: Complementary dermatological research peptide; copper-binding tripeptide operates via distinct mechanism.
  • BPC-157: Unrelated cytoprotective mechanism; no known melanocortin interaction in published literature.

    • Avoid combinations

  • Other non-selective melanocortin agonists: Additive MC4R activation increases risk of nausea, hypertension, and arousal side effects.
  • MAOIs / serotonergic agents (research-context): Theoretical interaction through central neuroendocrine pathways; not formally characterised.
  • Pre-existing atypical melanocytic lesions: MT-2 darkens existing nevi and may obscure dermoscopic surveillance of atypical moles.

    • Side Effects (Observed in Literature)

    Common

  • Nausea (especially with first 2-3 doses)
  • Facial flushing / transient vasodilation
  • Fatigue or drowsiness within 1-2 h of injection
  • Darkening of existing nevi and freckles
  • Reduced appetite
  • Injection-site reactions (erythema, minor swelling)

    • Rare

  • Priapism in male subjects
  • Rhabdomyolysis (isolated case reports with very high doses)
  • New-onset atypical pigmented macules
  • Posterior reversible encephalopathy (single case report, 2013)

    • Dose-dependent

  • Nausea intensity scales with dose and peak concentration
  • Pigmentation depth scales with cumulative dose
  • Central arousal effects scale with single-dose magnitude

    • Evidence Tier

    Overall: Mixed (human + animal)

    Mechanism is well-characterised in human and animal receptor pharmacology (Tier 1-2). Pigmentation and arousal endpoints have small human pilot studies (Tier 1). Long-term safety in research subjects is predominantly anecdotal (Tier 3). MT-2 itself is not FDA-approved; bremelanotide (PT-141, closely related) is approved for HSDD.

    Tier 1 · Human clinical

  • Dorr et al. 2004, small human trial of MT-2 + UV combined tanning response (Arch Dermatol).
  • Wessells et al. 2000, human pilot assessing erectile response to MT-2 (Int J Impot Res).
  • Bremelanotide (PT-141) Phase III trials, read-across for MC4R pharmacology in humans.

    • Tier 2 · Animal

  • Hruby et al. 1995, MT-2 design, rodent receptor binding and in-vivo pigmentation (J Med Chem).
  • Ugwu et al. 1994, rat pharmacokinetics and oral bioavailability (Pharm Res).
  • Rodent appetite-suppression and sexual-behaviour models across the 1990s-2000s.

    • Tier 3 · Anecdotal

  • Large body of self-experiment reports on pigmentation onset, nausea patterns, and dose titration.
  • Reports of new atypical nevi and dermatology referrals in unsupervised use.

    • Certificates, databases & peer-reviewed sources

    Last reviewed: 16 June 2026 · New-U Research Compounds

  • Dorr RT et al. Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers. Arch Dermatol. 2004;140(7):827-35. · 2004 · PMID: 15262696
  • Hadley ME, Dorr RT. Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides. 2006;27(4):921-30. · 2006 · PMID: 16476498 · DOI: 10.1016/j.peptides.2005.01.029
  • Hruby VJ et al. Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10] alpha-melanocyte-stimulating hormone (4-10)-NH2 with bulky aromatic amino acids at position 7. J Med Chem. 1995;38(18):3454-61. · 1995 · PMID: 7658432
  • Ugwu SO et al. Skin pigmentation and pharmacokinetics of melanotan-I in humans. Biopharm Drug Dispos. 1997;18(3):259-69. · 1997 · PMID: 9113347
  • Wessells H et al. Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. Int J Impot Res. 2000;12 Suppl 4:S74-9. · 2000 · PMID: 11035391
  • Habbema L et al. Risks of unregulated use of alpha-melanocyte-stimulating hormone analogues: a review. Int J Dermatol. 2017;56(10):975-80. · 2017 · PMID: 28266027 · DOI: 10.1111/ijd.13585
  • PubMed: peer-reviewed literature on Melanotan-2
  • ClinicalTrials.gov: registered studies on Melanotan-2
  • Melanotan-2: Wikipedia
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    • Key Characteristics

  • Cyclic lactam-bridged heptapeptide analog of α-MSH
  • Non-selective MC1/3/4/5 receptor agonist
  • Crosses the blood-brain barrier for central effects
  • D-Phe7 substitution confers protease resistance
  • Active at sub-milligram subcutaneous doses
  • Precursor concept that led to FDA-approved PT-141
  • WADA-prohibited; not approved for human therapeutic use
  • Research-grade purity: >99% HPLC

    • Specifications

    Molecular Formula C 50 H 69 N 15 O 9 Molecular Weight 1024.18 Da Sequence Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH 2 Purity >99% (HPLC) Form Lyophilised powder Half-life ~1 h (IV, rodent) Route Subcutaneous injection Solubility Bacteriostatic water or sterile saline Storage Lyophilised: −20 °C freezer. Reconstituted: 1-6 °C, away from light.

    About Melanotan-2 (MT-2): Tanning, Libido, Dosage & Melanocortin Research Guide

    Melanotan-2 came out of a University of Arizona search for an α-MSH analog that could protect fair-skinned people from UV damage without requiring sun exposure. The cyclic structure and D-Phe substitution solved two problems at once - it made the peptide stable in the bloodstream, and it turned it into a much more potent agonist than the natural hormone it was modelled on.

    The non-selective profile is both MT-2's strength and its limitation. It does produce the expected UV-independent pigmentation, but it also activates MC4R in the hypothalamus, which is why research subjects routinely experience nausea, facial flushing, and changes in appetite and libido. That hypothalamic arm of the pharmacology is exactly what inspired the development of the more targeted MC4R agonist bremelanotide (PT-141).

    New-U Research Compounds supplies Melanotan-2 as a lyophilised powder at >99% HPLC purity, independently verified by third-party labs. Material is strictly for in-vitro and preclinical research. MT-2 is not approved for human therapeutic use, is a WADA-prohibited substance for competing athletes, and is not a substitute for medically supervised treatment of any condition.

  • Melanotan II - Wikipedia
  • Melanocortin 4 receptor - Wikipedia
  • Melanocortin 1 receptor - Wikipedia
  • Alpha-Melanocyte-stimulating hormone - Wikipedia

    • Customer Reviews

    New-U Melanotan 2 order

    First order for Melanotan 2 from New-U Research Compounds went smoothly. Checkout was easy, dispatch was quick and the product arrived sealed.

    - Aylin O****** · 30 August 2026

    Clean lab-use label

    The Melanotan 2 vial had clear research-use labelling and a readable batch code. Nice clean presentation overall, not messy or rushed.

    - Rory M****** · 30 August 2026

    Good packaging

    Melanotan 2 arrived in secure packaging with no damage to the vial or label. Tracking worked fine and the delivery updates were clear.

    - Tom B****** · 30 August 2026

    More in Tanning / Libido

  • Melanotan-1
  • PT-141
  • Oxytocin Acetate

    • Melanotan-2 vs related Tanning / Libido compounds

    Compound Price Purity spec COA Melanotan-2 from $109 >99% HPLC 2 published batches Melanotan-1 from $109 >99% HPLC On request PT-141 from $142 >99% HPLC On request

    Descriptive catalog comparison for research sourcing decisions - not dosing guidance.

    More on Melanotan-2

  • Melanotan-2 research guide
  • Buy Melanotan-2 - pricing & packs

    • Part of the Skin & cosmetic research research area — explore related compounds, guides and sources.

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