GLP-1 RC-R is a first-in-class triple agonist peptide developed by that simultaneously activates GLP-1, GIP, and glucagon receptors for comprehensive metabolic coverage.

How is GLP-1 RC-R different from GLP-1 RC-S?

GLP-1 RC-S activates only GLP-1 receptors. GLP-1 RC-R activates three receptors (GLP-1, GIP, and glucagon), adding hepatic thermogenesis and energy expenditure beyond appetite suppression alone.

What were the phase 2 trial results?

Published research (NEJM, 2023) reports body-composition reductions in metabolic-research populations using the highest-dose protocol, with the majority of participants reaching the primary endpoint.

What is the dosing protocol?

Clinical protocols use dose escalation: 1 mg → 2 mg → 4 mg → 8 mg → 12 mg over 20–24 weeks, administered once weekly via subcutaneous injection.

How is GLP-1 RC-R different from GLP-1 RC-T or GLP-1 RC-S?

GLP-1 RC-S targets one receptor (GLP-1), GLP-1 RC-T targets two (GLP-1 and GIP), and GLP-1 RC-R targets three (GLP-1, GIP, and glucagon). The glucagon arm is what drives the additional hepatic thermogenesis and liver-fat clearance that set GLP-1 RC-R apart in published research.

Why is the glucagon receptor useful here? Glucagon raises blood sugar, right?

It does, but at the right intensity and in combination with GLP-1, glucagon receptor agonism stimulates hepatic energy expenditure and fat oxidation without significant net glucose elevation. The GLP-1 arm offsets any glycemic downside while the glucagon arm delivers unique energy-balance effects.

Is GLP-1 RC-R an approved medicine?

No. GLP-1 RC-R is supplied for in-vitro and preclinical research only and is not approved as a medicine in any jurisdiction.

What is the typical research dose escalation?

Published research protocols use a step-up schedule from 1 mg weekly, doubling over several weeks to 2 mg, 4 mg, 8 mg, and ultimately 12 mg. The gradual escalation is designed to minimise GI signals as systems adapt to triple-receptor activation.

Lyophilised · batch-documented · discreet packaging

Research peptide

GLP-1 RC-R

Name: GLP-1 RC-R
Brand: New-U Research Peptides
SKU: glp-1-rc-r
Availability: InStock

- GLP-1/GIP/Glucagon Triple Receptor Agonist

GLP-1 RC-R is a 39-amino acid triple agonist that simultaneously activates the GLP-1, GIP, and glucagon receptors. The glucagon receptor component uniquely drives hepatic thermogenesis and energy expenditure beyond appetite suppression, with the largest body-composition effects reported in published incretin-class research.

>99% HPLC purity

4,894.6 Da mol. weight

Lyophilised Presentation

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Every batch independently verified by Janoshik & Freedom Diagnostics for purity and identity.

Full COA included

Certificate of Analysis confirms peptide purity, amino acid composition, and absence of contaminants.

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Every order ships in plain, unmarked packaging with full tracking. No external branding or product details visible.

Research-grade

Uniform vial presentation, consistent labeling, and batch-level documentation every time.

10-vial pack

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Research use only. All compounds are sold strictly for in-vitro research and educational purposes. Not approved for human use, therapeutic application, or as food or cosmetic products. By purchasing, you agree to use these products only for legitimate research purposes.

GLP-1 RC-R

Third-party tested

Full COA included

Discreet shipping

Research-grade

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