Hexarelin is a synthetic hexapeptide growth hormone secretagogue and one of the most potent GHRPs studied. It also has direct cardioprotective effects via CD36 receptor binding.

How does Hexarelin differ from GHRP-2 and GHRP-6?

Hexarelin produces the strongest GH pulse among GHRPs but also has unique cardioprotective effects via CD36 binding that are independent of GH secretion. It has more cortisol and prolactin elevation than Ipamorelin.

What are the cardioprotective effects?

Hexarelin binds CD36 receptors in cardiac tissue, providing protection against ischaemia-reperfusion injury and improving cardiac function in animal models, independent of GH release.

Can Hexarelin be stacked with GHRH peptides?

Yes. Combining Hexarelin with a GHRH analogue like CJC-1295 or Sermorelin produces synergistic GH pulses significantly greater than either compound alone.

How is hexarelin different from GHRP-6?

Hexarelin is a more potent version of the GHRP-6 scaffold with two non-natural amino-acid substitutions (D-2-methyltryptophan and D-phenylalanine) that improve stability and GH-releasing potency. It also has clearer CD36-mediated cardiac effects than the simpler GHRP-6.

What is the CD36 mechanism doing in cardiac tissue?

CD36 is a scavenger receptor that handles fatty acid uptake and calcium channel modulation in cardiomyocytes. Hexarelin activation of cardiac CD36 improves calcium handling and has been proposed as a mechanism for its cardioprotective effects in post-ischemic injury models.

Does hexarelin cause cortisol elevation?

Yes, hexarelin produces some cortisol and prolactin elevation at higher doses, more than ipamorelin but generally less than GHRP-6. Low-dose protocols minimise those secondary effects while preserving GH release.

How should hexarelin be stored?

Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The non-natural amino acid substitutions give it better shelf stability than simpler GHRPs.

Hexarelin vs ipamorelin - how do they compare?

Both are ghrelin-receptor (GHSR) agonists that release growth hormone, but hexarelin is the more potent GH releaser and adds CD36-mediated cardiac activity, while ipamorelin is the cleaner, more selective option with minimal cortisol, prolactin or appetite effect. Hexarelin also desensitises faster with continuous exposure. See our Hexarelin vs Ipamorelin research comparison for the full mechanism breakdown.

What hexarelin dosage is used in research?

Research protocols describe low-microgram subcutaneous amounts, often split through the day, with lower amounts used to limit cortisol/prolactin rise and receptor desensitisation. New-U publishes this as descriptive research context only - it is not a dosing instruction, and hexarelin is supplied strictly for laboratory research, not human use.

What is hexarelin studied for?

Beyond growth-hormone release, hexarelin is studied for CD36-mediated cardioprotective effects in post-ischaemic injury models and for calcium-handling in cardiomyocytes - an angle the simpler GHRPs lack. These are preclinical research findings; New-U makes no therapeutic claims and sells hexarelin for research use only.

Does hexarelin lose effect over time (desensitisation)?

Yes - continuous high-amount exposure downregulates the ghrelin receptor and blunts the GH response faster than with ipamorelin, which is why research protocols favour lower amounts and cycling. Reported for research context only, not a human-use protocol.

Lyophilised · batch-documented · discreet packaging

>99% Purity // Janoshik Verified // Cardioprotective GHRP // 6 Amino Acids

Hexarelin

Name: Hexarelin
Brand: New-U Research Peptides
SKU: hexarelin
Availability: InStock

Examorelin // MF-6003 // CAS 140703-51-1 // Potent GH-Releasing Peptide

The most potent growth hormone releasing peptide studied. Unique cardioprotective effects via CD36 receptor binding.

Hexarelin is a 6 amino acid peptide and the most potent GH-releasing peptide studied. Beyond growth hormone release, Hexarelin directly protects the heart by binding to CD36 receptors in heart tissue - an effect completely independent of GH. Research shows it protects against damage when blood flow is restored after blockage and improves heart function in animal models.

Most Potent GH-releasing peptide studied

CD36 Cardioprotective binding

6 Amino acids

4–8 Weeks Typical cycle length

Third-party tested

Every batch independently verified by Janoshik & Freedom Diagnostics for purity and identity.

Full COA included

Certificate of Analysis confirms peptide purity, amino acid composition, and absence of contaminants.

Discreet shipping

Every order ships in plain, unmarked packaging with full tracking. No external branding or product details visible.

Research-grade

Uniform vial presentation, consistent labeling, and batch-level documentation every time.

10-vial pack

View Certificate of Analysis COA

Janoshik & Freedom Diagnostics verified
Certificate of analysis per batch
Direct-from-manufacturer sourcing
Discreet, unmarked packaging

Resources

Hexarelin Research & Reconstitution Guides

Learn more

Hexarelin Research Guide

Keep exploring

Research Resources

Research use only. All compounds are sold strictly for in-vitro research and educational purposes. Not approved for human use, therapeutic application, or as food or cosmetic products. By purchasing, you agree to use these products only for legitimate research purposes.

Hexarelin

Third-party tested

Full COA included

Discreet shipping

Research-grade

Explore More

Hexarelin Research & Reconstitution Guides

How to Reconstitute Peptides

Reconstitution Calculator

Hexarelin Research Guide

Hexarelin - Plain-English Guide

How to Read a COA

How to Store Peptides

Research Resources