What is CJC-1295 DAC?

CJC-1295 DAC is a modified growth hormone-releasing hormone (GHRH) analogue conjugated with a Drug Affinity Complex. The DAC binds reversibly to serum albumin, extending the half-life to 6–8 days and enabling sustained elevation of GH and IGF-1 levels with infrequent dosing.

How is CJC-1295 DAC different from CJC-1295 no DAC?

The DAC (Drug Affinity Complex) modification binds to albumin in the bloodstream, extending the half-life from approximately 30 minutes (no DAC) to 6–8 days. This means CJC-1295 DAC produces sustained, continuously elevated GH levels, while the no-DAC version produces short pulsatile GH bursts that more closely mirror natural secretion.

How often is CJC-1295 DAC dosed?

Due to the extended 6–8 day half-life from the DAC modification, CJC-1295 DAC is typically dosed once or twice per week via subcutaneous injection. This is far less frequent than non-DAC GHRH peptides which require daily dosing.

Can CJC-1295 DAC be stacked with GHRPs?

Yes. CJC-1295 DAC is frequently combined with GH-releasing peptides such as Ipamorelin or GHRP-2. The GHRH analogue provides sustained baseline GH elevation while the GHRP adds amplified pulsatile release, creating a synergistic dual-pathway approach.

What does "DAC" actually mean?

DAC stands for "Drug Affinity Complex". It is a small chemistry tag - specifically maleimidopropionic acid - attached to the C-terminal lysine of the peptide. When you inject the peptide, the DAC reacts with the free thiol of cysteine-34 on serum albumin, forming a covalent bond. The peptide then piggy-backs on albumin for days.

How is CJC-1295 DAC different from the no-DAC version?

Both share the same tetrasubstituted GHRH(1-29) backbone. The DAC version carries the albumin-binding tag and lasts ~6-8 days; the no-DAC version (often called Modified GRF 1-29) has no DAC tag and lasts roughly 30 minutes. DAC is used for sustained elevation; no-DAC is used for physiologic pulses.

Why combine CJC-1295 with ipamorelin?

GHRH analogs like CJC-1295 and ghrelin-receptor agonists like ipamorelin hit two different receptors (GHRHR and GHSR) that synergise in GH release. Combining them produces larger, cleaner GH pulses than either peptide alone, which is why this is a standard research pairing.

How should CJC-1295 DAC be stored?

Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The DAC chemistry is relatively stable once the peptide is in solution, but plan dosing to use reconstituted material within the standard peptide-stability window.

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>99% Purity // Janoshik Verified // DAC-Modified GHRH // Long-Acting

CJC

Name: CJC-1295 (with DAC)
Brand: New-U Research Peptides
SKU: cjc-1295-dac
Availability: InStock

Drug Affinity Complex GHRH Analogue // CAS 863288-34-0 // Sustained GH Release

Long-acting GHRH with albumin-binding DAC modification. Once-weekly dosing for sustained GH and IGF-1 elevation.

CJC-1295 with DAC is a modified growth hormone-releasing hormone analogue conjugated with a Drug Affinity Complex (DAC) that binds reversibly to serum albumin. This modification dramatically extends the half-life from minutes (native GHRH) to approximately 6–8 days, enabling once-weekly dosing while maintaining continuously elevated GH and IGF-1 levels. Unlike pulsatile GHRH peptides such as Sermorelin or CJC-1295 no DAC, this compound creates a sustained baseline of GH stimulation rather than short bursts.

6–8 Days Half-life (DAC)

1×/Week Typical dose frequency

Sustained GH elevation pattern

3–6 Months Typical cycle length

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Research use only. All compounds are sold strictly for in-vitro research and educational purposes. Not approved for human use, therapeutic application, or as food or cosmetic products. By purchasing, you agree to use these products only for legitimate research purposes.

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