How does MOTS-c differ from other metabolic peptides like AOD-9604?

MOTS-c is unique because it originates from mitochondrial DNA rather than being a synthetic analog. It targets the AMPK pathway and mitochondrial function directly, whereas AOD-9604 is a modified GH fragment focused on lipolysis.

What is the typical research dosing protocol for MOTS-c?

Published protocols range from 5–10 mg per week, administered twice weekly or every other day via subcutaneous injection. Conservative protocols start at 5 mg/week. Some researchers use 5–15 mg daily.

Can MOTS-c be stacked with other metabolic peptides?

Yes. MOTS-c is commonly combined with 5-Amino-1MQ for dual metabolic pathway activation, AOD-9604 for complementary fat metabolism, or BPC-157 for systemic repair alongside metabolic support.

What is a mitochondrial-derived peptide?

A mitochondrial-derived peptide (MDP) is a short bioactive peptide encoded directly by mitochondrial DNA - specifically by small open reading frames hidden inside genes for mitochondrial ribosomal RNAs. MOTS-c (from 12S rRNA) and humanin (from 16S rRNA) are the two best-studied examples. Their discovery made mitochondria into a genuine endocrine organ that signals to the rest of the body.

Is MOTS-c actually an exercise mimetic?

In preclinical models, yes. MOTS-c reproduces several characteristic metabolic effects of exercise - AMPK activation, improved insulin sensitivity, increased mitochondrial biogenesis, restored running capacity in aged animals - without the animal actually exercising. Whether those effects translate to humans in comparable ways is still an open research question.

When is MOTS-c best administered in research protocols?

Morning administration, 30-60 minutes before fasted exercise, is the pattern most commonly used. The timing aligns exogenous MOTS-c with the window where endogenous production naturally peaks during exercise, and fasted state maximises AMPK responsiveness.

How should MOTS-c be stored?

Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. MOTS-c is reasonably stable in solution within the normal peptide-handling window.

Lyophilised · batch-documented · discreet packaging

>99% Purity // Janoshik Verified // Mitochondrial Peptide // 16 Amino Acids

MOTS

Name: MOTS-C
Brand: New-U Research Peptides
SKU: mots-c
Availability: InStock

Mitochondrial Open Reading Frame Peptide // MW 2174.6 g/mol // AMPK Activator

The mitochondrial genome's own metabolic regulator. One of the few known peptides encoded within mitochondrial DNA.

MOTS-c is a 16-amino acid peptide encoded within the mitochondrial genome (12S rRNA), making it one of the few known mitochondria-derived peptides. It functions as a metabolic regulator, activating AMPK and promoting glucose uptake in skeletal muscle through GLUT4 translocation. Research demonstrates reversal of high-fat diet-induced insulin resistance and extension of lifespan in multiple animal models.

16 Amino acids

AMPK Primary pathway

mtDNA Mitochondrial origin

5–10 mg Typical weekly dose

Third-party tested

Every batch independently verified by Janoshik & Freedom Diagnostics for purity and identity.

Full COA included

Certificate of Analysis confirms peptide purity, amino acid composition, and absence of contaminants.

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Research-grade

Uniform vial presentation, consistent labeling, and batch-level documentation every time.

10-vial pack

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Certificate of analysis per batch
Direct-from-manufacturer sourcing
Discreet, unmarked packaging

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Research use only. All compounds are sold strictly for in-vitro research and educational purposes. Not approved for human use, therapeutic application, or as food or cosmetic products. By purchasing, you agree to use these products only for legitimate research purposes.

MOTS

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Full COA included

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