FOXO4-DRI is a D-retro-inverso peptide that disrupts the FOXO4-p53 interaction in senescent cells, restoring p53-mediated apoptosis and selectively clearing aged, dysfunctional cells.

How does FOXO4-DRI differ from other senolytics like dasatinib + quercetin?

FOXO4-DRI is a peptide-based senolytic that selectively targets the FOXO4-p53 axis in senescent cells. Small-molecule senolytics like D+Q inhibit broader survival pathways (tyrosine kinases, Bcl-2), which may affect a wider range of cell types.

What was shown in the 2017 Nature paper?

Baar et al. (2017) demonstrated that FOXO4-DRI selectively induced apoptosis in senescent cells, restored fitness in aged mice, improved kidney function, and reversed age-related fur loss - all without harming healthy tissue.

Is FOXO4-DRI safe for human use?

FOXO4-DRI is sold for research purposes only and is not approved for human therapeutic use. Animal data shows selective action on senescent cells, but human clinical trials have not been completed.

What is a "senolytic" and why do they matter?

A senolytic is a compound that selectively kills senescent cells - cells that have stopped dividing but refuse to die and produce a damaging pro-inflammatory secretome. In animal studies, clearing senescent cells extends healthspan and improves tissue function. FOXO4-DRI is one of the best-characterised peptide senolytics, specifically targeting the FOXO4-p53 axis that keeps senescent cells alive.

Why does FOXO4-DRI use D-amino acids?

D-retro-inverso topology (all D-amino acids in reverse order) preserves the side-chain orientation that a protein-protein interaction interface needs to see, while making the peptide resistant to proteases that normally chew up L-peptides. This is especially important for a senolytic, which needs to reach senescent cells in multiple tissues without being degraded in transit.

Will FOXO4-DRI harm healthy cells?

Baar et al. (Cell, 2017) showed that FOXO4-DRI selectively kills senescent cells while sparing non-senescent dividing cells in vitro. The selectivity comes from the fact that senescent cells specifically rely on FOXO4 to sequester p53, whereas healthy cells do not have the same dependency. That said, senolytic selectivity is an active research area and appropriate caution is warranted.

How should FOXO4-DRI be stored?

Keep the lyophilised powder frozen at −20 °C for long-term storage, or at 2-8 °C during active research use. Reconstitute with sterile PBS or bacteriostatic water. The D-retro-inverso topology gives it unusually good stability in solution compared with L-peptides.

Lyophilised · batch-documented · discreet packaging

>99% Purity // Janoshik Verified // D-Retro-Inverso Peptide // Senolytic

FOXO4

Name: FOXO4-DRI
Brand: New-U Research Peptides
SKU: foxo4-dri
Availability: InStock

D-Retro-Inverso Senolytic Peptide // FOXO4-p53 Disruptor // Longevity Research

Targeted elimination of senescent cells. The first peptide-based senolytic with published reversal of ageing phenotypes.

FOXO4-DRI is a D-amino acid retro-inverso peptide designed to disrupt the FOXO4-p53 protein-protein interaction in senescent cells. Senescent cells accumulate with ageing and drive chronic inflammation (inflammaging) via the senescence-associated secretory phenotype (SASP). By blocking FOXO4 from sequestering p53 in the nucleus, the peptide restores p53's apoptotic function specifically in senescent cells, triggering their elimination without harming healthy cells. Published research in Nature Medicine (Baar et al., 2017) demonstrated reversal of ageing phenotypes and increased physical fitness in mice.

Senolytic Selective cell clearance

Nature Med Published 2017

D-AA Protease-resistant

3 Days/Mo Intermittent protocol

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Research use only. All compounds are sold strictly for in-vitro research and educational purposes. Not approved for human use, therapeutic application, or as food or cosmetic products. By purchasing, you agree to use these products only for legitimate research purposes.

FOXO4

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