How is GLP-1 RC-T different from GLP-1 RC-S?

GLP-1 RC-S activates only the GLP-1 receptor. GLP-1 RC-T activates both the GLP-1 and GIP receptors. The added GIP receptor activity drives additional satiety and adipose-tissue effects, producing larger weight loss and HbA1c reductions in published research.

Why is GLP-1 RC-T described as imbalanced?

It is a full agonist at GIPR (comparable potency to native GIP) but biased at GLP-1R, favouring cAMP signalling over β-arrestin recruitment. The asymmetry preserves the GIP arm while reducing the receptor desensitisation that can blunt long-term efficacy at GLP-1R.

How is GLP-1 RC-T stored?

Keep the lyophilised powder at −20 °C in the freezer. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. Avoid repeated freeze-thaw cycles, which can damage the fatty acid tail and reduce potency.

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